Tissue pharmacokinetics of 2′,3′-dideoxyinosine in rats

Physiological parameters in laboratory animals and humans.

1993 • 2,747 citations

Clinical pharmacokinetics; concepts and applications

1989 • 2,266 citations

HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease

1993 • 1,822 citations

Detection of AIDS Virus in Macrophages in Brain Tissue from AIDS Patients with Encephalopathy

1986 • 1,694 citations

Inhibition of the in vitro infectivity and cytopathic effect of human T-lymphotrophic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) by 2',3'-dideoxynucleosides.

1986 • 1,032 citations

HTLV-III Infection in Brains of Children and Adults with AIDS Encephalopathy

1985 • 899 citations

Clinical Pharmacokinetics: Concepts and Applications.

1981 • 406 citations

Initial studies on the cellular pharmacology of 2′,3′-dideoxycytidine, an inhibitor of HTLV-III infectivity

1986 • 326 citations

Factors determining the activity of 2',3'-dideoxynucleosides in suppressing human immunodeficiency virus in vitro.

1988 • 158 citations

Initial studies on the cellular pharmacology of 2′,3′-dideoxyinosine, an inhibitor of HIV infectivity

1987 • 142 citations

Initial studies on the cellular pharmacology of 2',3'-dideoxyadenosine, an inhibitor of HTLV-III infectivity

1987 • 99 citations

Overview of the Preclinical Development of an Antiretroviral Drug, 2′,3′-Dideoxyinosine

1990 • 55 citations

Pancreatitis in human immunodeficiency virus-infected children receiving dideoxyinosine.

1993 • 46 citations

Pancreatitis and pancreatic dysfunction in patients taking dideoxyinosine

1992 • 41 citations

Central nervous system targeting of 2',3'-dideoxyinosine via adenosine deaminase-activated 6-halo-dideoxypurine prodrugs

1992 • 37 citations

Gastrointestinal and hepatic first-pass elimination of 2',3'-dideoxyinosine in rats.

1993 • 25 citations

Pharmacokinetics of the anti-AIDS drug 2',3'-dideoxyinosine in the rat.

1990 • 25 citations

DISTRIBUTION OF BLOOD IN THE FUNCTIONAL KIDNEY

1956 • 23 citations

Effect of the volatile anesthetics on aniline hydroxylase and aminopyrine demethylase

1970 • 19 citations

High-performance liquid chromatographic analysis of 2',3'-dideoxyinosine in biological samples

1991 • 18 citations

Keystone's Blunt Message: 'It's The Virus, Stupid'

1993 • 17 citations

Dose dependence in the plasma pharmacokinetics and uptake kinetics of 2',3'-dideoxyinosine into brain and cerebrospinal fluid of rats.

1991 • 17 citations

Acute interaction of drugs—I

1973 • 16 citations

Nonlinear disposition of intravenous 2',3'-dideoxyinosine in rats.

1992 • 16 citations

Determination of 2′,3′-Dideoxyinosine in Plasma by High Performance Liquid Chromatography

1987 • 14 citations

In vivo and in vitro effects of the azidothymidine analog dideoxyinosine on the exocrine pancreas of the rat.

1992 • 11 citations

Disposition of 2′, 3′-dideoxyadenosine and 2′, 3′-dideoxyinosine in mice

1989 • 10 citations

A High-Performance Liquid Chromatographic Assay for Dideoxyinosine in Monkey Plasma and Urine

1992 • 9 citations

Red blood cell volume and distribution before and after bleed-out in the rat

1960 • 8 citations

Acute effects of a nucleoside analog dideoxyinosine (DDI) on the pancreas

1992 • 5 citations

Effect of ciprofloxacin on the disposition of 14C-dideoxyinosine-derived radioactivity in the rat.

1993 • 1 citations