Focusing on IL1-promotion of β-amyloid precursor protein synthesis as an early event in Alzheimer's disease

Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease.

1989 • 1,752 citations

Biology of interleukin 1

1988 • 1,547 citations

Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein

1989 • 1,237 citations

Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells.

1989 • 586 citations

Visualization and characterization of interleukin 1 receptors in brain.

1987 • 451 citations

Cell-derived proteases and protease inhibitors as regulators of neurite outgrowth

1988 • 337 citations

Amyloid Protein Precursor Messenger RNAs: Differential Expression in Alzheimer's Disease

1988 • 254 citations

Interleukin 1 increases stability and transcription of mRNA encoding nerve growth factor in cultured rat fibroblasts.

1988 • 244 citations

Nerve Growth Factor

1978 • 243 citations

Nerve growth factor

1974 • 207 citations

In situ hybridization of nucleus basalis neurons shows increased beta-amyloid mRNA in Alzheimer disease.

1988 • 186 citations

Differential regulation of amyloid-beta-protein mRNA expression within hippocampal neuronal subpopulations in Alzheimer disease.

1988 • 176 citations

Three types of amyloid protein precursor mRNA in human brain: Their differential expression in Alzheimer's disease

1988 • 150 citations

Effects of nerve growth factor on cholinergic brain neurons

1989 • 112 citations

CELLULAR LOCALIZATION OF MESSENGER RNA ENCODING AMYLOID-BETA-PROTEIN IN NORMAL TISSUE AND IN ALZHEIMER DISEASE

1988 • 104 citations

The alpha-subunit of mouse 7 S nerve growth factor is an inactive serine protease.

1984 • 47 citations

Multiple forms of beta-amyloid peptide precursor RNAs in a single cell type

1988 • 21 citations