Flecainide-induced arrhythmia in canine ventricular epicardium. Phase 2 reentry?

Preliminary Report: Effect of Encainide and Flecainide on Mortality in a Randomized Trial of Arrhythmia Suppression after Myocardial Infarction

1989 • 3,227 citations

Electrophysiological mechanisms of ventricular arrhythmias resulting from myocardial ischemia and infarction

1989 • 995 citations

Nonuniform Recovery of Excitability in Ventricular Muscle

1964 • 939 citations

Flow of "injury" current and patterns of excitation during early ventricular arrhythmias in acute regional myocardial ischemia in isolated porcine and canine hearts. Evidence for two different arrhythmogenic mechanisms.

1980 • 604 citations

Transient outward current prominent in canine ventricular epicardium but not endocardium.

1988 • 442 citations

Flecainide: Its proarrhythmic effect and expected changes on the surface electrocardiogram

1984 • 279 citations

Antiarrhythmic Drugs: a Possible Cause of Out-of-Hospital Cardiac Arrest

1983 • 227 citations

Slow Conduction and Reentry in the Ventricular Conducting System

1972 • 207 citations

Characteristics of reflection as a mechanism of reentrant arrhythmias and its relationship to parasystole.

1980 • 179 citations

Effects of flecainide and quinidine on human atrial action potentials. Role of rate-dependence and comparison with guinea pig, rabbit, and dog tissues.

1990 • 163 citations

Proarrhythmic response to sodium channel blockade. Theoretical model and numerical experiments.

1991 • 139 citations

Risk factors for the development of proarrhythmic events

1987 • 131 citations

Mechanism of Ventricular Arrhythmias Caused by Increased Dispersion of Repolarization

1985 • 121 citations

Evidence for reentry as a mechanism of cardiac arrhythmias

1975 • 121 citations

Voltage- and time-dependent depression of maximum rate of depolarisation of guinea-pig ventricular action potentials by two new antiarrhythmic drugs, flecainide and lorcainide

1983 • 117 citations

Amplification of flecainide-induced ventricular conduction slowing by exercise. A potentially significant clinical consequence of use-dependent sodium channel blockade.

1989 • 115 citations

Proarrhythmic effects of antiarrhythmic drugs

1987 • 110 citations

Interactions of flecainide with guinea pig cardiac sodium channels. Importance of activation unblocking to the voltage dependence of recovery.

1990 • 110 citations

Effects of flecainide on the electrophysiologic properties of isolated canine and rabbit myocardial fibers

1985 • 98 citations

The genesis of cardiac arrhythmias

1966 • 93 citations

Ventricular Tachyarrhythmias Related to Early Afterdepolarizations and Triggered Firing: Relationship to QT Interval Prolongation and Potential Therapeutic Role for Calcium Channel Blocking Agents

1990 • 73 citations

Characterization of a new oral antiarrhythmic drug, flecainide (R818)

1981 • 72 citations

Clinical electrophysiologic study of antiarrhythmic properties of flecainide: Acute intraventricular delayed conduction and prolonged repolarization in regular paced and premature beats using intracardiac monophasic action potentials with programmed stimulation

1981 • 72 citations

Occurrence of exercise-induced and spontaneous wide complex tachycardia during therapy with flecainide for complex ventricular arrhythmias: A probable proarrhythmic effect

1987 • 66 citations

Frequency-Dependent Effects of Several Class I Antiarrhythmic Drugs on &OV0312;max of Action Potential Upstroke in Canine Cardiac Purkinje Fibers

1985 • 64 citations

Early Afterdepolarizations: Role in Conduction Block, “Prolonged Repolarization‐Dependent Reexcitation,” and Tachyarrhythmias in the Human Heart

1985 • 62 citations

Antiarrhythmic and Hemodynamic Actions of Flecainide Acetate (R-818) in the Ischemic Porcine Heart

1979 • 61 citations

Effect of Flecainide on Action Potentials and Alternating Current-Induced Arrhythmias in Mammalian Myocardium

1982 • 48 citations

Physiologic Basis of Premature Beats and Sustained Tachycardias

1973 • 42 citations

Arrhythmogenic actions of antiarrhythmic drugs

1987 • 41 citations

Cellular electrophysiological effects of flecainide on human atrial fibres

1990 • 28 citations

Aggravation of electrically provoked ventricular tachycardia during treatment with propafenone

1985 • 27 citations

A proarrhythmic response to sodium channel blockade: modulation of the vulnerable period in guinea pig ventricular myocardium.

1992 • 26 citations

Reflected reentry, delayed conduction, and electrotonic inhibition in segmentally depressed atrial tissues

1989 • 25 citations

The proarrhythmic effects of antiarrhythmic drugs

1987 • 24 citations

Quinidine‐Induced Early Afterdepolarizations and Triggered Activity

1989 • 19 citations

Epicardial Reflection as a Cause of Incessant Ventricular Bigeminy

1988 • 17 citations

Exercise-induced ventricular tachycardia as a manifestation of flecainide toxicity

1986 • 12 citations

Electrotonus and reflection.

1990 • 7 citations

Models of Parasystole and Reflection

1983 • 7 citations

Reflection as a mechanism of reentrant cardiac arrhythmias.

1987 • 7 citations

Clinical use of antiarrhythmic drugs

1983 • 7 citations