Amplification of flecainide-induced ventricular conduction slowing by exercise. A potentially significant clinical consequence of use-dependent sodium channel blockade.

Applied Statistics

1984 • 981 citations

Time- and voltage-dependent interactions of antiarrhythmic drugs with cardiac sodium channels

1977 • 899 citations

Antiarrhythmic Agents: The Modulated Receptor Mechanism of Action of Sodium and Calcium Channel-Blocking Drugs

1984 • 544 citations

Mechanisms of use-dependent block of sodium channels in excitable membranes by local anesthetics

1984 • 333 citations

Flecainide: Its proarrhythmic effect and expected changes on the surface electrocardiogram

1984 • 279 citations

Kinetics of onset of rate-dependent effects of Class I antiarrhythmic drugs are important in determining their effects on refractoriness in guinea-pig ventricle, and provide a theoretical basis for their subclassification

1983 • 279 citations

Block of inactivated sodium channels and of depolarization-induced automaticity in guinea pig papillary muscle by amiodarone.

1984 • 213 citations

Effects of tetrodotoxin, lidocaine, verapamil, and AHR-2666 on Ouabain-induced delayed afterdepolarizations in canine Purkinje fibers.

1980 • 186 citations

Classification by type of ventricular arrhythmia predicts frequency of adverse cardiac events from flecainide

1986 • 153 citations

Acute electrophysiological effects of flecainide acetate on cardiac conduction and refractoriness in man.

1982 • 139 citations

Voltage- and time-dependent depression of maximum rate of depolarisation of guinea-pig ventricular action potentials by two new antiarrhythmic drugs, flecainide and lorcainide

1983 • 117 citations

Rate-dependent effects of intravenous lidocaine, procainamide and amiodarone on intraventricular conduction

1985 • 94 citations

Ventricular Tachyarrhythmias in the Long QT Syndromes

1984 • 93 citations

Proarrhythmic effects of the new antiarrhythmic agent flecainide acetate

1984 • 82 citations

Comparative electrophysiologic effects of intravenous amiodarone and desethylamiodarone in dogs: evidence for clinically relevant activity of the metabolite.

1987 • 79 citations

Occurrence of exercise-induced and spontaneous wide complex tachycardia during therapy with flecainide for complex ventricular arrhythmias: A probable proarrhythmic effect

1987 • 66 citations

Frequency-Dependent Effects of Several Class I Antiarrhythmic Drugs on &OV0312;max of Action Potential Upstroke in Canine Cardiac Purkinje Fibers

1985 • 64 citations

Frequency-dependent effects of calcium antagonists on atrioventricular conduction and refractoriness: demonstration and characterization in anesthetized dogs.

1986 • 58 citations

Use-dependent effects of lidocaine on conduction in canine myocardium: application of the modulated receptor hypothesis in vivo.

1986 • 47 citations

Frequency-dependent effects of amitriptyline on ventricular conduction and cardiac rhythm in dogs.

1985 • 46 citations

Rate-dependent effects of procainamide on his-purkinje conduction in man

1985 • 29 citations

Arrhythmogenesis of antiarrhythmic drugs

1988 • 23 citations

Use dependence of amiodarone during the sinus tachycardia of exercise in coronary artery disease

1988 • 17 citations