Cholinergic muscarinic mechanisms regulate neuropeptide Y gene expression via protein kinase C in human neuroblastoma cells

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C

1991 • 2,499 citations

Turning off the signal: desensitization of β‐adrenergic receptor function

1990 • 1,241 citations

Neuropeptide Y: Anatomical distribution and possible function in mammalian nervous system

1986 • 499 citations

Rat neuropeptide Y precursor gene expression. mRNA structure, tissue distribution, and regulation by glucocorticoids, cyclic AMP, and phorbol ester.

1988 • 318 citations

Phenotypic changes of human neuroblastoma cells in culture induced by 12‐O‐tetradecanoyl‐phorbol‐13‐acetate

1981 • 255 citations

Modulation of memory processing by neuropeptide Y

1987 • 222 citations

Central nervous system pharmacology of neuropeptide Y

1995 • 201 citations

An integrative hypothesis concerning the pathogenesis and progression of Alzheimer's disease

1986 • 192 citations

Neuroreceptor changes in Alzheimer disease.

1992 • 161 citations

II. Cortical neurons immunoreactive with antisera against neuropeptide Y are altered in Alzheimer's‐type dementia

1985 • 146 citations

Regulation of hypothalamic neuropeptide-Y neurons by growth hormone in the rat.

1996 • 123 citations

Desensitization of cell signalling mediated by phosphoinositidase C

1993 • 112 citations

Direct labeling of rat M3-muscarinic receptors by [3H]4DAMP

1989 • 110 citations

Presence and regulation of tyrosinase activity in human neuroblastoma cell variants in vitro.

1985 • 110 citations

Distribution of altered hippocampal neurons and axons immunoreactive with antisera against neuropeptide Y in Alzheimer's‐type dementia

1986 • 106 citations

Reduced concentrations of galanin, arginine vasopressin, neuropeptide Y and peptide YY in the temporal cortex but not in the hypothalamus of brains from schizophrenics

1991 • 96 citations

Muscarinic Receptor‐Mediated Inositol 1,4,5‐Trisphosphate Formation in SH‐SY5Y Neuroblastoma Cells Is Regulated Acutely by Cytosolic Ca²⁺ and by Rapid Desensitization

1994 • 88 citations

Steroidal regulation of hypothalamic neuropeptide Y release and gene expression.

1992 • 83 citations

Age‐Related Bidirectional Changes in Neuropeptide Y Peptides in Rat Adrenal Glands, Brain, and Blood

1988 • 74 citations

Agonist activation of transfected human M1 muscarinic acetylcholine receptors in CHO cells results in down-regulation of both the receptor and the α subunit of the G-protein Gq

1993 • 67 citations

Transcriptional Regulation of the Neuropeptide Y Gene by Nerve Growth Factor: Antagonism by Glucocorticoids and Potentiation by Adenosine 3′,5′-Monophosphate and Phorbol Ester

1990 • 66 citations

The Intact Human Neuroblastoma Cell (SH‐SY5Y) Exhibits High‐Affinity [³H]Pirenzepine Binding Associated with Hydrolysis of Phosphatidylinositols

1988 • 58 citations

Neuropeptide Y and Memory Processing

1990 • 54 citations

Expression of the human neuropeptide Y gene.

1990 • 51 citations

Cerebrospinal fluid concentrations of neuropeptide Y in depressed patients and in controls.

1992 • 49 citations

Peripheral and Central Adrenergic Influences on Brain Systems Involved in the Modulation of Memory Storage^a

1985 • 45 citations

The Selective Protein Kinase C Inhibitor GF 109203X Inhibits Phorbol Ester-Induced Morphological and Functional Differentiation of SH-SY5Y Human Neuroblastoma Cells

1993 • 43 citations

Phorbol esters alter muscarinic receptor binding and inhibit polyphosphoinositide breakdown in human neuroblastoma (SH-SY5Y) cells

1986 • 42 citations

On the interaction of gallamine with muscarinic receptor subtypes

1990 • 39 citations

Activation of the human NPY gene during neuroblastoma cell differentiation: induced transcriptional activities of AP-1 and AP-2.

1994 • 38 citations

Age‐Dependent Increase in Neuropeptide Y Gene Expression in Rat Adrenal Gland and Specific Brain Areas

1991 • 34 citations

A role for protein kinase C subtypes α and ε in phorbol-ester-enhanced K+- and carbachol-evoked noradrenaline release from the human neuroblastoma SH-SY5Y

1994 • 31 citations

Forskolin and phorbol ester stimulation of neuropeptide Y (NPY) production and secretion by aggregating fetal brain cells in culture: evidence for regulation of NPY biosynthesis at transcriptional and posttranscriptional levels.

1992 • 31 citations

Contrasting effects of phorbol ester and agonist-mediated activation of protein kinase C on phosphoinositide and Ca2+ signalling in a human neuroblastoma

1996 • 28 citations

Oxidation-reduction states of pyridine nucleotide and cytochrome P-450 during mixed-function oxidation in perfused rat liver.

1981 • 27 citations

Fos and Jun form cell specific protein complexes at the neuropeptide tyrosine promoter.

1994 • 25 citations

Transcriptional vs. posttranscriptional control of neuropeptide Y gene expression.

1995 • 24 citations

Ca²⁺/Calmodulin‐Dependent Transcriptional Activation of Neuropeptide Y Gene Induced by Membrane Depolarization: Determination of Ca²⁺‐ and Cyclic AMP/Phorbol 12‐Myristate 13‐Acetate‐Responsive Elements

1996 • 22 citations

Age-related change of neuropeptide Y-immunoreactive neurons in the cerebral cortex of aged rats

1996 • 17 citations

An early and transient period of protein synthesis is required for induction of neuropeptide Y-mRNA by phorbol ester and forskolin in aggregate cultures of fetal brain cells

1993 • 13 citations

Potassium-and carbachol-evoked released of [3H]noradrenaline from human neuroblastoma cells, SH-SY5Y

1990 • 10 citations

A comparison between muscarinic receptor occupancy, inositol 1,4,5-trisphosphate accumulation and Ca2+ mobilization in permeabilized SH-SY5Y neuroblastoma cells

1994 • 4 citations

Intravenous physostigmine increases cerebrospinal fluid neuropeptide-Y

1989 • 2 citations