The action of valproate on spontaneous epileptiform activity in the absence of synaptic transmission and on evoked changes in [Ca2+]0 and [K+]0 in the hippocampal slice

The role of calcium in neuromuscular facilitation

1968 • 1,331 citations

Non‐selective conductance in calcium channels of frog muscle: calcium selectivity in a single‐file pore.

1984 • 643 citations

Extracellular free calcium and potassium during paroxysmal activity in the cerebral cortex of the cat

1977 • 636 citations

Comparison of the action of baclofen with gamma‐aminobutyric acid on rat hippocampal pyramidal cells in vitro.

1985 • 488 citations

Long-term and short-term plasticity in the CA1, CA3, and dentate regions of the rat hippocampal slice

1976 • 444 citations

Synchronized bursting of CA1 hippocampal pyramidal cells in the absence of synaptic transmission

1982 • 441 citations

Electrophysiology of Epilepsy

1985 • 392 citations

The antagonism of amino acid‐induced excitations of rat hippocampal CA1 neurones in vitro.

1983 • 360 citations

Synchronous Neural Afterdischarges in Rat Hippocampal Slices Without Active Chemical Synapses

1982 • 353 citations

Mechanism of anticonvulsant action of valproate

1982 • 344 citations

Paired‐pulse and frequency facilitation in the CA1 region of the in vitro rat hippocampus

1980 • 340 citations

Role of presynaptic calcium ions and channels in synaptic facilitation and depression at the squid giant synapse.

1982 • 291 citations

N‐methyl aspartate activates voltage‐dependent calcium conductance in rat hippocampal pyramidal cells.

1983 • 281 citations

Low‐calcium field burst discharges of CA1 pyramidal neurones in rat hippocampal slices.

1984 • 269 citations

The relationship between extracellular calcium concentrations and the induction of hippocampal long-term potentiation

1979 • 234 citations

Extracellular calcium and potassium changes in hippocampal slices

1980 • 220 citations

Undershoots following stimulus-induced rises of extracellular potassium concentration in cerebral cortex of cat

1975 • 180 citations

Anticonvulsant action of ethanolamine-O-sulphate and di-n-propylacetate and the metabolism of γ-aminobutyric acid (GABA) in mice with audiogenic seizures

1976 • 175 citations

Stimulus- and amino acid-induced calcium and potassium changes in rat neocortex

1985 • 171 citations

Interhippocampal Impulses

1960 • 169 citations

The anticonvulsive action of adenosine: a postsynaptic, dendritic action by a possible endogenous anticonvulsant

1984 • 166 citations

Slow transmission of neural activity in hippocampal area CA1 in absence of active chemical synapses

1984 • 164 citations

Electrophysiological and pharmacological characteristics of facilitation of hippocampal population spikes by stimulation of the medial septum

1982 • 160 citations

Valproic acid augments GABA-mediated postsynaptic inhibition in cultured mammalian neurons

1979 • 160 citations

The role of calcium ions in tetanic and post‐tetanic increase of miniature end‐plate potential frequency.

1978 • 156 citations

Spontaneous epileptiform activity of ca1 hippocampal neurons in low extracellular calcium solutions

1983 • 150 citations

Excitatory amino acids and central synaptic transmission

1984 • 139 citations

Adenosine enhances afterhyperpolarization and accommodation in hippocampal pyramidal cells

1984 • 125 citations

Valproate induced changes in GABA metabolism at the subcellular level

1981 • 125 citations

Extracellular calcium activity changes in cat sensorimotor cortex induced by iontophoretic application of aminoacids

1980 • 109 citations

Control of Hippocampal Output by Afferent Volley Frequency

1967 • 109 citations

Effect of n‐dipropylacetate on amino acid concentrations in mouse brain: correlations with anti‐convulsant activity

1978 • 108 citations

The clearing of excess potassium from extracellular space in spinal cord and cerebral cortex

1978 • 102 citations

Effect of Inhibitors of GABA Aminotransferase on the Metabolism of GABA in Brain Tissue and Synaptosomal Fractions

1981 • 98 citations

Research Progress in Epilepsy

1982 • 95 citations

Sodium Valproate Increases Potassium Conductance in Aplysia Neurons

1978 • 90 citations

Cerebral Blood Flow, Metabolism and Epilepsy

1986 • 86 citations

Effects of anticonvulsants on spontaneous epileptiform activity which develops in the absence of chemical synaptic transmission in hippocampal slices

1985 • 83 citations

Dissociation between drug-induced increases in nerve terminal and non-nerve terminal pools of GABA in vivo

1979 • 83 citations

Depression of synaptic transmission by diphenylhydantoin

1977 • 80 citations

THE EFFECT OF SODIUM‐n‐DIPROPYL ACETATE ON γ‐AMINOBUTYRIC ACID‐DEPENDENT INHIBITION IN THE RAT CORTEX AND SUBSTANTIA NIGRA IN RELATION TO ITS ANTICONVULSANT ACTIVITY

1980 • 79 citations

Acute anticonvulsant activity of structural analogues of valproic acid and changes in brain GABA and aspartate content

1983 • 75 citations

Sodium valproate enhancement of gamma-aminobutyric acid (GABA) inhibition: electrophysiological evidence for anticonvulsant activity.

1981 • 71 citations

Epilepsy and Motor System

1984 • 68 citations

Human brain, plasma, and cerebrospinal fluid concentration of sodium valproate after 72 hours of therapy

1981 • 63 citations

Sodium di-n-propylacetate (valproate) potentiates responses to GABA and muscimol on single central neurones

1980 • 56 citations

Depth distribution and mechanism of changes in extracellular K⁺ and Ca²⁺ concentrations in the hippocampus

1982 • 53 citations

Aspartate-induced changes in extracellular free calcium in ‘in vitro’ hippocampal slices of rats

1982 • 50 citations

Effects of GABA on presumed presynaptic Ca2+ entry in hippocampal slices

1983 • 46 citations

Effect of metabolites of valproic acid on the metabolism of GABA in brain and brain nerve endings

1981 • 44 citations

Interactions of Di‐n‐Propylacetate, Gabaculine, and Aminooxyacetic Acid: Anticonvulsant Activity and the γ‐Aminobutyrate System

1981 • 42 citations

GABA and baclofen reduce changes in extracellular free calcium in area CA1 of rat hippocampal slices

1984 • 40 citations

Analysis of carbamazepine actions in hippocampal slices of the rat

1983 • 39 citations

Central actions of valproate sodium

1979 • 39 citations

Presynaptic involvement in frequency facilitation in the hippocampal slice

1983 • 38 citations

Sustained extracellular potentials in the cat spinal cord during the microiontophoretic application of excitatory amino acids

1979 • 32 citations

The presynaptic effects of valproic acid in the isolated frog spinal cord

1981 • 28 citations

Sodium di-n-propylacetate (valproate) action on single neurons in rat cerebral cortex and hippocampus

1979 • 20 citations

Changes in [Ca2+]0, [K+]0 and neuronal activity during oenanthotoxin-induced epilepsy in cat sensorimotor cortex

1983 • 20 citations

How Valproate and Phenytoin Affect the Ionic Conductances and Active Transport Characteristics of the Crayfish Giant Axon

1981 • 18 citations

Drugs affecting GABA.

1980 • 17 citations

Valproic acid serum levels and protection against kindled amygdaloid scizures in the rat

1981 • 17 citations

PHARMACOLOGICAL DIFFERENCES BETWEEN CA3 AND DENTATE GRANULE CELLS IN HIPPOCAMPAL SLICES

1981 • 15 citations

Free sodium valproate monitoring.

1982 • 11 citations

Electrophysiological and behavioural correlations during the manipulations of GABA functions in the Substantia Nigra by n-dipropylacetate and Picrotoxin

1979 • 6 citations