Structure and function of the CD94 C‐type lectin receptor complex involved in recognition of HLA class I molecules

In search of the ‘missing self’: MHC molecules and NK cell recognition

1990 • 2,600 citations

RECEPTORS FOR HLA CLASS-I MOLECULES IN HUMAN NATURAL KILLER CELLS

1996 • 871 citations

Cloning of Immunoglobulin-Superfamily Members Associated with HLA-C and HLA-B Recognition by Human Natural Killer Cells

1995 • 735 citations

Recruitment of Tyrosine Phosphatase HCP by the Killer Cell Inhibitory Receptor

1996 • 625 citations

Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains

1995 • 575 citations

The T Cell Receptor as a Multicomponent Signalling Machine: CD4/CD8 Coreceptors and CD45 in T Cell Activation

1992 • 539 citations

P58 molecules as putative receptors for major histocompatibility complex (MHC) class I molecules in human natural killer (NK) cells. Anti-p58 antibodies reconstitute lysis of MHC class I-protected cells in NK clones displaying different specificities.

1993 • 537 citations

The Bw4 public epitope of HLA-B molecules confers reactivity with natural killer cell clones that express NKB1, a putative HLA receptor.

1995 • 507 citations

The Ly-49 and NKR-P1 Gene Families Encoding Lectin-Like Receptors on Natural Killer Cells: The NK Gene Complex

1993 • 465 citations

Existence of both inhibitory (p58) and activatory (p50) receptors for HLA-C molecules in human natural killer cells.

1995 • 446 citations

Human natural killer cell receptors involved in MHC class I recognition are disulfide-linked heterodimers of CD94 and NKG2 subunits.

1996 • 441 citations

DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells.

1991 • 430 citations

Human NKR-P1A. A disulfide-linked homodimer of the C-type lectin superfamily expressed by a subset of NK and T lymphocytes.

1994 • 408 citations

Identification of four subsets of human CD3-CD16+ natural killer (NK) cells by the expression of clonally distributed functional surface molecules: correlation between subset assignment of NK clones and ability to mediate specific alloantigen recognition.

1990 • 388 citations

Development of human T and natural killer cells

1995 • 379 citations

The natural killer cell receptor specific for HLA-A allotypes: a novel member of the p58/p70 family of inhibitory receptors that is characterized by three immunoglobulin-like domains and is expressed as a 140-kD disulphide-linked dimer.

1996 • 365 citations

Human and mouse killer-cell inhibitory receptors recruit PTP1C and PTP1D protein tyrosine phosphatases.

1996 • 362 citations

A human killer inhibitory receptor specific for HLA-A1,2.

1996 • 347 citations

NKB1: a natural killer cell receptor involved in the recognition of polymorphic HLA-B molecules.

1994 • 343 citations

Killer cell inhibitory receptors specific for HLA-C and HLA-B identified by direct binding and by functional transfer

1995 • 338 citations

The human leukocyte antigen (HLA)-C-specific "activatory" or "inhibitory" natural killer cell receptors display highly homologous extracellular domains but differ in their transmembrane and intracytoplasmic portions.

1996 • 337 citations

Superantigen-Dependent, Cell-Mediated Cytotoxicity Inhibited by MHC Class I Receptors on T Lymphocytes

1995 • 316 citations

Natural killer cell receptors

1995 • 314 citations

Molecular cloning of NKB1. A natural killer cell receptor for HLA-B allotypes.

1995 • 309 citations

Peptide Specificity in the Recognition of MHC Class I by Natural Killer Cell Clones

1995 • 308 citations

Inhibitory MHC class I receptors on NK cells and T cells

1996 • 288 citations

Molecular cloning, expression, and chromosomal localization of the human earliest lymphocyte activation antigen AIM/CD69, a new member of the C-type animal lectin superfamily of signal-transmitting receptors.

1993 • 280 citations

Identification of a common T/natural killer cell progenitor in human fetal thymus.

1994 • 280 citations

Oligosaccharide ligands for NKR-P1 protein activate NK cells and cytotoxicity

1994 • 256 citations

A novel surface antigen expressed by a subset of human CD3- CD16+ natural killer cells. Role in cell activation and regulation of cytolytic function.

1990 • 254 citations

Generation of Allospecific Natural Killer Cells by Stimulation Across a Polymorphism of HLA-C

1993 • 241 citations

The enigma of the natural killer cell

1995 • 236 citations

Cytolytic T lymphocytes displaying natural killer (NK)-like activity: expression of NK-related functional receptors for HLA class I molecules (p58 and CD94) and inhibitory effect on the TCR-mediated target cell lysis or lymphokine production

1995 • 221 citations

Involvement of HLA class I alleles in natural killer (NK) cell-specific functions: expression of HLA-Cw3 confers selective protection from lysis by alloreactive NK clones displaying a defined specificity (specificity 2).

1992 • 218 citations

Amino acid substitutions can influence the natural killer (NK)-mediated recognition of HLA-C molecules. Role of serine-77 and lysine-80 in the target cell protection from lysis mediated by "group 2" or "group 1" NK clones.

1995 • 216 citations

Phosphotyrosines in the killer cell inhibitory receptor motif of NKB1 are required for negative signaling and for association with protein tyrosine phosphatase 1C.

1996 • 213 citations

Tyrosine phosphorylation of a human killer inhibitory receptor recruits protein tyrosine phosphatase 1C.

1996 • 210 citations

Molecular characterization of human CD94: A type II membrane glycoprotein related to the C‐type lectin superfamily

1995 • 207 citations

Human natural killer cell receptors for HLA-class I molecules. Evidence that the Kp43 (CD94) molecule functions as receptor for HLA-B alleles.

1994 • 193 citations

Binding of diverse peptides to MHC class I molecules inhibits target cell lysis by activated natural killer cells

1995 • 180 citations

Heterogeneous phenotypes of expression of the NKB1 natural killer cell class I receptor among individuals of different human histocompatibility leukocyte antigens types appear genetically regulated, but not linked to major histocompatibililty complex haplotype.

1996 • 158 citations

Alloantigen recognition by two human natural killer cell clones is associated with HLA-C or a closely linked gene.

1992 • 157 citations

Peptide sequence requirements for the recognition of HLA-B*2705 by specific natural killer cells.

1996 • 142 citations

A novel functional cell surface dimer (Kp43) expressed by natural killer cells and T cell receptor-gamma/delta+ T lymphocytes. I. Inhibition of the IL-2-dependent proliferation by anti-Kp43 monoclonal antibody.

1990 • 136 citations

CD94 functions as a natural killer cell inhibitory receptor for different HLA class I alleles: identification of the inhibitory form of CD94 by the use of novel monoclonal antibodies

1996 • 133 citations

A novel surface molecule homologous to the p58/p50 family of receptors is selectively expressed on a subset of human natural killer cells and induces both triggering of cell functions and proliferation

1996 • 130 citations

Class I-induced resistance to natural killing: identification of nonpermissive residues in HLA-A2.

1991 • 128 citations

A multigene family on human chromosome 12 encodes natural killer-cell lectins

1993 • 125 citations

Functional ambivalence of the Kp43 (CD94) NK cell-associated surface antigen.

1995 • 124 citations

Of ITAMs and ITIMs: turning on and off the B cell antigen receptor.

1995 • 124 citations

Human decidual leukocytes from early pregnancy contain high numbers of gamma delta+ cells and show selective down-regulation of alloreactivity.

1992 • 122 citations

Ly-49A, a receptor for H-2Dd, has a functional carbohydrate recognition domain

1994 • 115 citations

The alpha 1/alpha 2 domains of class I HLA molecules confer resistance to natural killing.

1989 • 95 citations

Adhesion receptors in lymphocyte activation

1994 • 90 citations

The NKB1 and HP-3E4 NK cells receptors are structurally distinct glycoproteins and independently recognize polymorphic HLA-B and HLA-C molecules.

1995 • 82 citations

Alternatively spliced forms of human killer inhibitory receptors

1996 • 73 citations

Peptide-induced modulation of target cell sensitivity to natural killing.

1992 • 71 citations

Coexpression of two functionally independent p58 inhibitory receptors in human natural killer cell clones results in the inability to kill all normal allogeneic target cells.

1995 • 65 citations

A novel functional cell surface dimer (Kp43) expressed by natural killer cells and gamma/delta TCR+ T lymphocytes. II. Modulation of natural killer cytotoxicity by anti-Kp43 monoclonal antibody.

1991 • 61 citations

Tyrosine kinase-dependent activation of human NK cell functions upon stimulation through a 58-kDa surface antigen selectively expressed on discrete subsets of NK cells and T lymphocytes.

1994 • 61 citations

Biochemical and serologic evidence for the existence of functionally distinct forms of the CD94 NK cell receptor.

1996 • 59 citations

Clonotypic differences in signaling from CD94 (kp43) on NK cells lead to divergent cellular responses.

1996 • 58 citations

Human natural killer cell inhibitory receptors bind to HLA class I molecules

1996 • 52 citations

NK-cell receptors and recognition of MHC class I molecules

1996 • 51 citations

Expression of HLA-C molecules confers target cell resistance to some non-major histocompatibility complex-restricted T cells in a manner analogous to allospecific natural killer cells.

1995 • 44 citations

Natural killer lectin-like receptors have divergent carboxyl-termini, distinct from C-type lectins

1994 • 40 citations

Expression of functional molecules by human CD3 ⁻ decidual granular leucocyte clones

1996 • 36 citations

Phospholipase D activation in human natural killer cells through the Kp43 and CD16 surface antigens takes place by different mechanisms. Involvement of the phospholipase D pathway in tumor necrosis factor alpha synthesis.

1992 • 36 citations

Identification of Natural Killer (NK) Cells in Lesions of Human Cutaneous Graft-Versus-Host Disease: Expression of a Novel NK-Associated Surface Antigen (Kp43) in Mononuclear Infiltrates

1991 • 35 citations

NKG2‐C is a receptor on human natural killer cells that recognizes structures on K562 target cells

1995 • 25 citations

Stimulation of IL-2-activated natural killer cells through the Kp43 surface antigen up-regulates TNF-alpha production involving the LFA-1 integrin.

1993 • 21 citations