At least 12 genotypes of hepatitis C virus predicted by sequence analysis of the putative E1 gene of isolates collected worldwide.

CLUSTAL: a package for performing multiple sequence alignment on a microcomputer

1988 • 3,446 citations

Genetic organization and diversity of the hepatitis C virus.

1991 • 1,717 citations

Molecular cloning of the human hepatitis C virus genome from Japanese patients with non-A, non-B hepatitis.

1990 • 1,208 citations

Structure and organization of the hepatitis C virus genome isolated from human carriers

1991 • 970 citations

Molecular biology of the hepatitis C viruses: Implications for diagnosis, development and control of viral disease

1991 • 854 citations

Hepatitis C virus shares amino acid sequence similarity with pestiviruses and flaviviruses as well as members of two plant virus supergroups.

1990 • 640 citations

Variable and hypervariable domains are found in the regions of HCV corresponding to the flavivirus envelope and NS1 proteins and the pestivirus envelope glycoproteins

1991 • 611 citations

Nucleotide sequence and mutation rate of the H strain of hepatitis C virus.

1991 • 609 citations

Full-length sequence of a hepatitis C virus genome having poor homology to reported isolates: Comparative study of four distinct genotypes

1992 • 578 citations

The 5'-terminal sequence of the hepatitis C virus genome.

1990 • 481 citations

Nucleotide sequence of the genomic RNA of hepatitis C virus isolated from a human carrier: comparison with reported isolates for conserved and divergent regions

1991 • 476 citations

Sequence variability in the 5' non-coding region of hepatitis C virus: identification of a new virus type and restrictions on sequence diversity

1993 • 437 citations

Analysis of a new hepatitis C virus type and its phylogenetic relationship to existing variants

1992 • 430 citations

Sequence analysis of the 5' noncoding region of hepatitis C virus.

1992 • 410 citations

Genetic drift of hepatitis C virus during an 8.2-year infection in a chimpanzee: Variability and stability

1992 • 384 citations

Hypervariable regions in the putative glycoprotein of hepatitis C virus

1991 • 353 citations

Genomic structure of the human prototype strain H of hepatitis C virus: comparison with American and Japanese isolates.

1991 • 281 citations

Improvement of PCR amplified DNA sequencing with the aid of detergents

1990 • 278 citations

Importance of primer selection for the detection of hepatitis C virus RNA with the polymerase chain reaction assay.

1992 • 275 citations

At least five related, but distinct, hepatitis C viral genotypes exist.

1992 • 267 citations

Nucleotide sequence of dengue 2 RNA and comparison of the encoded proteins with those of other flaviviruses

1988 • 221 citations

The Taiwanese hepatitis C virus genome: Sequence determination and mapping the 5′ termini of viral genomic and antigenomic RNA

1992 • 189 citations

A new type of hepatitis C virus in patients in Thailand

1992 • 171 citations

The Putative Nucleocapsid and Envelope Protein Genes of Hepatitis C Virus Determined by Comparison of the Nucleotide Sequences of Two Isolates Derived from an Experimentally Infected Chimpanzee and Healthy Human Carriers

1990 • 151 citations

Molecular cloning of hepatitis C virus genome from a single Japanese carrier: sequence variation within the same individual and among infected individuals

1992 • 148 citations

Genomic Characterization and Mutation Rate of Hepatitis C Virus Isolated From a Patient Who Contracted Hepatitis During an Epidemic of non-A, non-B Hepatitis in Japan

1992 • 61 citations

Identification of hepatitis C viruses with a nonconserved sequence of the 5' untranslated region

1992 • 34 citations

Sequence analysis of putative structural regions of hepatitis C virus isolated from 5 Japanese patients with hepatocellular carcinoma

1993 • 18 citations

Genomic typing of hepatitis C viruses present in China

1992 • 14 citations