Muscarinic cholinergic mediation of opiate and non-opiate environmentally induced analgesias

Statistical principles in experimental design.

1962 • 27,228 citations

A METHOD FOR DETERMINING LOSS OF PAIN SENSATION

1941 • 3,174 citations

The Pharmacological Basis of Therapeutics

1976 • 1,403 citations

The Pharmacological Basis of Therapeutics

1976 • 1,283 citations

The central cholinergic system studied by choline acetyltransferase immunohistochemistry in the cat

1981 • 966 citations

Organization of Endogenous Opiate and Nonopiate Pain Control Systems

1982 • 793 citations

The origin of descending pathways in the dorsolateral funiculus of the spinal cord of the cat and rat: Further studies on the anatomy of pain modulation

1979 • 629 citations

Evidence for the Neuropeptide Cholecystokinin as an Antagonist of Opiate Analgesia

1983 • 582 citations

Evidence that an excitatory connection between the periaqueductal gray and nucleus raphe magnus mediates stimulation produced analgesia

1979 • 433 citations

Autoradiographic localization of muscarinic cholinergic receptors in rat brainstem

1981 • 376 citations

Antagonism of the frequency of phenylquinone-induced writhing in the mouse by weak analgesics and nonanalgesics.

1959 • 340 citations

Stereospecific Nicotine Receptors on Rat Brain Membranes

1980 • 319 citations

Antagonism of stimulation-produced analgesia by p-CPA, a serotonin synthesis inhibitor

1972 • 284 citations

Localization of cholinergic muscarinic receptors in rat brain by light microscopic radioautography

1976 • 219 citations

Determination and characterization of the antinociceptive activity of intraventricularly administered acetylcholine in mice.

1975 • 213 citations

Antinociceptive effects of central and systemic administrations of nicotine in the rat

1979 • 181 citations

The somatotopic organization of the nucleus raphe magnus and surrounding brain stem structures as revealed by HRP slow-release gels

1980 • 134 citations

Narcotic-antagonist analgesics: interactions with cholinergic systems.

1969 • 125 citations

Learned Helplessness: All of us were Right (And Wrong): Inescapable Shock has Multiple Effects

1979 • 123 citations

Regional distribution of nicotinic acetylcholine receptor in rat brain

1977 • 113 citations

Biology of Cholinergic Function

1977 • 100 citations

A comparison of the antinociceptive actions of cholinomimetic and morphine‐like drugs

1970 • 99 citations

Comparison of the antinociceptive activities of physostigmine, oxotremorine and morphine in the mouse

1971 • 92 citations

Studies on the central antinociceptive action of cholinomimetic agents

1969 • 86 citations

Non-opiate analgesia induced by carbachol microinjection into the pontine parabrachial region of the cat

1984 • 86 citations

The effect of biogenic amine modifiers on morphine analgesia and its antagonism by naloxone

1976 • 84 citations

Effects of narcotic analgesic agonists and antagonists on rat brain acetylcholine.

1973 • 80 citations

Brain acetylcholine levels and inhibition of the tail-flick reflex in mice.

1969 • 79 citations

The Analgetic Action of Morphine, Eserine and Prostigmine Studied by a Modified Hardy-Wolff-Goodell Method.

1945 • 78 citations

Identification and somatotopic organization of nuclei projecting via the dorsolateral funiculus in rats: A retrograde tracing study using HRP slow-release gels

1981 • 73 citations

The neural basis of footshock analgesia: The role of specific ventral medullary nuclei

1983 • 61 citations

The anti-tremorine effect of some drugs as determined by Haffner's method of testing analgesia in mice.

1958 • 61 citations

The analgesic and sedative effects of nicotine in white mice, rabbits and golden hamsters.

1968 • 56 citations

Involvement of central muscarinic cholinergic mechanisms in opioid stress analgesia

1983 • 48 citations

Fear is not critical to classically conditioned analgesia: The effects of periaqueductal gray lesions and administration of chlordiazepoxide

1984 • 47 citations

Bilateral lesions of the dorsolateral funiculus of the cat spinal cord: Effects on basal nociceptive reflexes and nociceptive suppression produced by cholinergic activation of the pontine parabrachial region

1984 • 47 citations

The effect of scopolamine on local glucose metabolism in rat brain

1979 • 46 citations

The neurochemical basis of footshock analgesia: the role of spinal cord serotonin and norepinephrine

1984 • 45 citations

Behavioral and electroencephalographic effects of micro-injections of neurohumors into the midbrain reticular formation

1968 • 43 citations

Central neurohumoral systems involved with narcotic agonists and antagonists.

1970 • 39 citations

The role of acetylcholine in the function of the nucleus raphe magnus and in the interaction of this nucleus with the periaqueductal gray

1982 • 37 citations

Production of Analgesia by Cholinergic Drugs

1973 • 36 citations

Cholinergic influences on escape deficits produced by uncontrollable stress

1981 • 34 citations

SOME NEW ASPECTS OF MORPHINE ACTION EFFECTS ON PAIN

1940 • 34 citations

The neural basis of footshock analgesia: The effect of periaqueductal gray lesions and decerebration

1983 • 33 citations

THE ROLE OF EPINEPHRINE IN ANALGESIA

1948 • 30 citations

Effect of diisopropyl phosphofluoridate on analgesia and motor behavior in the rat

1978 • 28 citations

Antinociceptive action of oxotremorine and regional turnover of rat brain noradrenaline, dopamine and 5-HT

1975 • 28 citations

NEW CLINICAL ASPECTS OF THE ANALGESIC ACTION OF MORPHINE

1940 • 26 citations

Tolerance development to the antinociceptive actions of morphine, amphetamine, physostigmine and 2-aminoindane in the mouse

1974 • 23 citations

The effects of scopolamine and pilocarpine upon the aversive threshold of the rat

1973 • 23 citations

Modulation of the aversive qualities of shock through a central inhibitory cholinergic system in the rat

1976 • 22 citations

Comparison of the antinociceptive activity of intraventricularly administered acetylcholine to narcotic antinociception

1981 • 21 citations

Morphine tolerance and physical dependence: Influence of cholinergic agonists and antagonists

1976 • 19 citations

Central neurotransmitter systems in the morphine suppression of jaw-opening reflex in rabbits: The cholinergic system

1979 • 16 citations

Analgesic activity after intracerebral injection in the mouse.

1969 • 14 citations

Modulation of cholinergic activity and the aversive threshold in the rat

1974 • 14 citations

Ellagic acid cent depress as an analgesic in mice abstract

1967 • 13 citations

Effects of the intracerebroventricular injection of antinociceptive doses of acetylcholine on the stereospecific binding of 3H-dihydromorphine

1981 • 2 citations