The neural basis of footshock analgesia: The effect of periaqueductal gray lesions and decerebration

Statistical principles in experimental design.

1962 • 27,228 citations

A stereotaxic atlas of the rat brain

1967 • 4,710 citations

A METHOD FOR DETERMINING LOSS OF PAIN SENSATION

1941 • 3,174 citations

A stereotaxic atlas of the rat brain

1980 • 2,782 citations

Surgery in the Rat during Electrical Analgesia Induced by Focal Brain Stimulation

1969 • 1,355 citations

Topographic atlas of catecholamine and acetylcholinesterase‐containing neurons in the rat brain. I. Forebrain (telencephalon, diencephalon)

1974 • 1,255 citations

Endogenous pain control mechanisms: Review and hypothesis

1978 • 1,217 citations

EVIDENCE FOR THE EXISTENCE OF MONOAMINE NEURONS IN THE CENTRAL NERVOUS SYSTEM. II. EXPERIMENTALLY INDUCED CHANGES IN THE INTRANEURONAL AMINE LEVELS OF BULBOSPINAL NEURON SYSTEMS.

1965 • 1,004 citations

Topographic atlas of catecholamine and acetylcholinesterase‐containing neurons in the rat brain. II. Hindbrain (mesencephalon, rhombencephalon)

1974 • 799 citations

Organization of Endogenous Opiate and Nonopiate Pain Control Systems

1982 • 793 citations

Narcotic analgetics: CNS sites and mechanisms of action as revealed by intracerebral injection techniques

1977 • 656 citations

Spinal opiate analgesia: Characteristics and principles of action

1981 • 552 citations

SOME NEUROLOGICAL SPECIES DIFFERENCES ‐ A POSTERIORI*

1969 • 484 citations

Reversal of morphine and stimulus-produced analgesia by subtotal spinal cord lesions

1977 • 303 citations

Antagonism of stimulation-produced analgesia by p-CPA, a serotonin synthesis inhibitor

1972 • 284 citations

Afferent connections of the rostral medulla of the cat: A neural substrate for midbrain‐medullary interactions in the modulation of pain

1981 • 283 citations

Evidence that raphe-spinal neurons mediate opiate and midbrain stimulation-produced analgesias

1978 • 283 citations

Evidence for opioid and non-opioid forms of stimulation-produced analgesia in the rat

1982 • 210 citations

Concurrent mapping of brain sites for sensitivity to the direct application of morphine and focal electrical stimulation in the production of antinociception in the rat

1977 • 164 citations

Opiate vs non-opiate footshock-induced analgesia (FSIA): The body region shocked is a critical factor

1982 • 139 citations

Classical conditioning of front paw and hind paw footshock induced analgesia (FSIA): Naloxone reversibility and descending pathways

1982 • 136 citations

The somatotopic organization of the nucleus raphe magnus and surrounding brain stem structures as revealed by HRP slow-release gels

1980 • 134 citations

Supramedullary afferents of the nucleus raphe magnus in the rat: A study using the transcannula HRP gel and autoradiographic techniques

1983 • 113 citations

Effects of pain-attenuating brain stimulation and morphine on electrical activity in the raphe nuclei of the awake rat

1977 • 101 citations

Opiate vs non-opiate eootshock induced analgesia (FSIA): Descending and intraspinal components

1982 • 90 citations

Physiologic evidence for a projection from periaqueductal gray to nucleus raphe magnus in the rat

1979 • 83 citations

Effects of focal electrical stimulation and morphine microinjection in the periaqueductal gray of the rat mesencephalon on neuronal activity in the medullary reticular formation

1980 • 77 citations

Electrophysiological evidence for a projection of the periaqueductal gray matter to nucleus raphe magnus in cat and rat

1980 • 69 citations

Comparison of the effects of ventral medullary lesions on systemic and microinjection morphine analgesia

1984 • 68 citations

Responses of neurons of the nucleus raphe magnus to noxious stimuli

1980 • 66 citations

Involvement of spinal opioid systems in footshock-induced analgesia: Antagonism by naloxone is possible only before induction of analgesia

1982 • 62 citations

Footshock induced analgesia in dependent neither on pituitary nor sympathetic activation

1982 • 61 citations

The neural basis of footshock analgesia: The role of specific ventral medullary nuclei

1983 • 61 citations

Responses of raphespinal and other bulbar raphe neurones to stimulation of the periaqueductal gray in the cat

1978 • 55 citations

Failure of spinal cord serotonin depletion to alter analgesia elicited from the periaqueductal gray

1982 • 54 citations

Fear is not critical to classically conditioned analgesia: The effects of periaqueductal gray lesions and administration of chlordiazepoxide

1984 • 47 citations

The neurochemical basis of footshock analgesia: the role of spinal cord serotonin and norepinephrine

1984 • 45 citations

Role of Endorphins in Endogenous Pain Control Systems1

2015 • 43 citations

Effects of morphine and naloxone on the responses to noxious stimulation of neurones in the nucleus reticularis paragigantocellularis

1981 • 36 citations

Effect of morphine administered in the periaqueductal gray and at the recording locus on nociresponsive neurons in the medullary reticular formation

1981 • 20 citations