BRCA1 Basal-like Breast Cancers Originate from Luminal Epithelial Progenitors and Not from Basal Stem Cells

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

2005 • 44,461 citations

Exploration, normalization, and summaries of high density oligonucleotide array probe level data

2003 • 10,537 citations

A Gene-Expression Signature as a Predictor of Survival in Breast Cancer

2002 • 6,428 citations

Repeated observation of breast tumor subtypes in independent gene expression data sets

2003 • 5,356 citations

Supervised Risk Predictor of Breast Cancer Based on Intrinsic Subtypes

2009 • 4,183 citations

Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits

2009 • 3,176 citations

Diagnosis of multiple cancer types by shrunken centroids of gene expression

2002 • 2,932 citations

Immunohistochemical and Clinical Characterization of the Basal-Like Subtype of Invasive Breast Carcinoma

2004 • 2,644 citations

Generation of a functional mammary gland from a single stem cell

2006 • 1,939 citations

Tumor heterogeneity: Causes and consequences

2009 • 1,509 citations

Purification and unique properties of mammary epithelial stem cells

2006 • 1,502 citations

Prophylactic Oophorectomy in Carriers ofBRCA1orBRCA2Mutations

2002 • 1,448 citations

Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers

2009 • 1,390 citations

The molecular portraits of breast tumors are conserved across microarray platforms

2006 • 1,320 citations

Basal-Like Breast Cancer: A Critical Review

2008 • 1,137 citations

Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer

2001 • 1,020 citations

Biological and Molecular Heterogeneity of Breast Cancers Correlates with Their Cancer Stem Cell Content

2010 • 907 citations

The Tumor Suppressor p53 Regulates Polarity of Self-Renewing Divisions in Mammary Stem Cells

2009 • 666 citations

Control of mammary stem cell function by steroid hormone signalling

2010 • 650 citations

Prediction of BRCA1 Status in Patients with Breast Cancer Using Estrogen Receptor and Basal Phenotype

2005 • 610 citations

Stem cells in normal breast development and breast cancer

2003 • 551 citations

Stem cells in normal breast development and breast cancer

2003 • 544 citations

BRCA1 regulates human mammary stem/progenitor cell fate

2008 • 448 citations

Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1 -mutated basal-like breast cancer

2007 • 444 citations

Paracrine signaling through the epithelial estrogen receptor α is required for proliferation and morphogenesis in the mammary gland

2006 • 398 citations

Stem cells and breast cancer: A field in transit

2003 • 370 citations

Breast cancer molecular profiling with single sample predictors: a retrospective analysis

2010 • 351 citations

CD24 staining of mouse mammary gland cells defines luminal epithelial, myoepithelial/basal and non-epithelial cells

2005 • 308 citations

Dissociation of estrogen receptor expression and in vivo stem cell activity in the mammary gland

2006 • 291 citations

Basal cytokeratins and their relationship to the cellular origin and functional classification of breast cancer

2005 • 278 citations

β1 Integrin deletion from the basal compartment of the mammary epithelium affects stem cells

2008 • 248 citations

The Ets transcription factor Elf5 specifies mammary alveolar cell fate

2008 • 233 citations

Ablation of β1 integrin in mammary epithelium reveals a key role for integrin in glandular morphogenesis and differentiation

2005 • 215 citations

Molecular analysis reveals a genetic basis for the phenotypic diversity of metaplastic breast carcinomas

2009 • 199 citations

Molecular Basis for Estrogen Receptor Deficiency in BRCA1-Linked Breast Cancer

2007 • 188 citations

BRCA1 functions as a breast stem cell regulator

2004 • 168 citations

Transcriptome analysis of mammary epithelial subpopulations identifies novel determinants of lineage commitment and cell fate

2008 • 167 citations

Phenotypic characterization of BRCA1 and BRCA2 tumors based in a tissue microarray study with 37 immunohistochemical markers

2005 • 163 citations

An integrative genomic and transcriptomic analysis reveals molecular pathways and networks regulated by copy number aberrations in basal-like, HER2 and luminal cancers

2009 • 152 citations

A mouse model of basal‐like breast carcinoma with metaplastic elements

2007 • 134 citations

Do 'basal-like' breast cancers really exist?

2008 • 117 citations

Estrogen receptor-α and progesterone receptor are expressed in label-retaining mammary epithelial cells that divide asymmetrically and retain their template DNA strands

2006 • 109 citations

Identification and characterization of cancer initiating cells from BRCA1 related mammary tumors using markers for normal mammary stem cells

2008 • 79 citations

BRCA1 transcriptionally regulates genes associated with the basal-like phenotype in breast cancer

2009 • 76 citations

An integrative hypothesis about the origin and development of sporadic and familial breast cancer subtypes

2008 • 56 citations

Metaplasia — A Transdifferentiatlon Process that Facilitates Cancer Development: The Model of Gastric Intestinal Metaplasia

2006 • 44 citations

Cellular Mechanisms of Barrett's Esophagus Development

2009 • 11 citations

Targeted disruption of Brca1 in restricted compartments of the mouse mammary epithelia

2007 • 8 citations