Involvement of 5′-Flanking κB-like Sites withinbcl-x Gene in Silica-induced Bcl-x Expression

Mitochondria and Apoptosis

1998 • 8,909 citations

The Bcl-2 Protein Family: Arbiters of Cell Survival

1998 • 5,359 citations

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

1993 • 3,111 citations

An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death

1996 • 3,094 citations

Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production.

1988 • 2,865 citations

Massive Cell Death of Immature Hematopoietic Cells and Neurons in Bcl-x-Deficient Mice

1995 • 1,167 citations

Bcl-2 family proteins

1998 • 1,055 citations

The inhibitors of apoptosis (IAPs) and their emerging role in cancer

1998 • 985 citations

The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappa B that blocks TNFalpha -induced apoptosis

1999 • 721 citations

New Insights into the Role of Nuclear Factor-κB, a Ubiquitous Transcription Factor in the Initiation of Diseases

1999 • 717 citations

Nuclear Factor (NF)-κB–regulated X-chromosome–linked iap Gene Expression Protects Endothelial Cells from Tumor Necrosis Factor α–induced Apoptosis

1998 • 643 citations

Structure of NF-κB p50 homodimer bound to a κB site

1995 • 564 citations

Tumor Necrosis Factor Induces Bcl-2 and Bcl-x Expression through NFκB Activation in Primary Hippocampal Neurons

1999 • 552 citations

NF-κB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes

1999 • 526 citations

Structure of the NF-κB p50 homodimer bound to DNA

1995 • 525 citations

Caspase-9, Bcl-XL, and Apaf-1 Form a Ternary Complex

1998 • 523 citations

IEX -1L, an Apoptosis Inhibitor Involved in NF-κB-Mediated Cell Survival

1998 • 417 citations

The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex

1996 • 415 citations

Rel-dependent induction of A1 transcription is required to protect B cells from antigen receptor ligation-induced apoptosis

1999 • 410 citations

NF-kappa B activation of p53. A potential mechanism for suppressing cell growth in response to stress.

1994 • 361 citations

Divergent signalling via APO-1/Fas and the TNF receptor, two homologous molecules involved in physiological cell death.

1994 • 304 citations

Inactivation of bcl-2 Results in Progressive Degeneration of Motoneurons, Sympathetic and Sensory Neurons during Early Postnatal Development

1996 • 263 citations

WD-40 Repeat Region Regulates Apaf-1 Self-association and Procaspase-9 Activation

1998 • 252 citations

Expression of the bcl‐2 gene family in normal and malignant breast tissue: Low bax‐α expression in tumor cells correlates with resistance towards apoptosis

1995 • 242 citations

Activation-Dependent Transcriptional Regulation of the Human fas Promoter Requires NF-κB p50-p65 Recruitment

1999 • 232 citations

NF-κB-dependent inhibition of apoptosis is essential for host cell survival during Rickettsia rickettsii infection

1998 • 230 citations

Rapid DNA binding by nuclear factor kappa B in hepatocytes at the start of liver regeneration.

1995 • 215 citations

Pyrrolidine dithiocarbamate, a potent inhibitor of nuclear factor κB (NF-κB) activation, prevents apoptosis in human promyelocytic leukemia HL-60 cells and thymocytes

1994 • 211 citations

Activation of the B-cell Surface Receptor CD40 Induces A20, a Novel Zinc Finger Protein That Inhibits Apoptosis

1995 • 205 citations

Genomic organization, promoter region analysis, and chromosome localization of the mouse bcl-x gene.

1997 • 188 citations

Nuclear Factor-κB Regulates Induction of Apoptosis and Inhibitor of Apoptosis Protein-1 Expression in Vascular Smooth Muscle Cells

1999 • 165 citations

Human tumor necrosis factor alpha gene regulation in phorbol ester stimulated T and B cell lines.

1991 • 138 citations

Self-Reactive B Lymphocytes Overexpressing Bcl-xL Escape Negative Selection and Are Tolerized by Clonal Anergy and Receptor Editing

1998 • 120 citations

Importance of the Bcl-2 family in cell death regulation

1996 • 107 citations

Essential Role of NF-κB Activation in Silica-Induced Inflammatory Mediator Production in Macrophages

1995 • 101 citations

Predominant expression of the long isoform of Bcl‐x (Bcl‐xL) in human lymphomas

1996 • 94 citations

Bcl-Xshort is elevated following severe global ischemia in rat brains

1997 • 83 citations

TAFII105 mediates activation of anti-apoptotic genes by NF-kappa B

1998 • 81 citations

Bcl-2 overexpression results in reciprocal downregulation of Bcl-XL and sensitizes human testicular germ cell tumours to chemotherapy-induced apoptosis

1999 • 79 citations

A Physiologic Role of Bcl-xL Induced in Activated Macrophages

1998 • 76 citations

Calpain Contributes to Silica-Induced IκB-α Degradation and Nuclear Factor-κB Activation

1997 • 68 citations

The Structure and Complete Nucleotide Sequence of the Murine Gene Encoding Interleukin-1β Converting Enzyme (ICE)

1994 • 62 citations

NF-κB Activation by Triphenyltin Triggers Apoptosis in HL-60 Cells

1996 • 52 citations

Characterizing Mutagenesis in the Hprt Gene of Rat Alveolar Epithelial Cells

1995 • 35 citations

A novel NF-kappa B element within exon 1 of the murine c-myc gene.

1992 • 29 citations

Selective hyperexpression of c-jun oncoprotein by glass fiber- and silica-transformed BALB/c-3T3 cells

1997 • 7 citations