Central nervous system perivascular cells are immunoregulatory cells that connect the CNS with the peripheral immune system

Control of Viremia in Simian Immunodeficiency Virus Infection by CD8 ⁺ Lymphocytes

1999 • 2,206 citations

Detection of AIDS Virus in Macrophages in Brain Tissue from AIDS Patients with Encephalopathy

1986 • 1,694 citations

The Heterogeneity of Mononuclear Phagocytes in Lymphoid Organs: Distinct Macrophage Subpopulations in Rat Recognized by Monoclonal Antibodies ED1, ED2 and ED3

1985 • 1,605 citations

Perivascular Microglial Cells of the CNS Are Bone Marrow-Derived and Present Antigen in Vivo

1988 • 1,451 citations

The fine structure of the nervous system: The neurons and supporting cells

1976 • 1,334 citations

The Brain in AIDS: Central Nervous System HIV-1 Infection and AIDS Dementia Complex

1988 • 1,244 citations

CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia

1997 • 923 citations

Immunohistochemical localization of macrophages and microglia in the adult and developing mouse brain

1985 • 881 citations

Isolation and direct characterization of resident microglial cells from the normal and inflamed central nervous system.

1991 • 675 citations

Dementia in AIDS patients

1993 • 671 citations

Immunocytochemical quantitation of human immunodeficiency virus in the brain: Correlations with dementia

1995 • 663 citations

Normal adult ramified microglia separated from other central nervous system macrophages by flow cytometric sorting. Phenotypic differences defined and direct ex vivo antigen presentation to myelin basic protein-reactive CD4+ T cells compared.

1995 • 622 citations

Characterization of inducible cyclooxygenase in rat brain

1995 • 539 citations

Bone Marrow-derived Elements in the Central Nervous System: An Immunohistochemical and Ultrastructural Survey of Rat Chimeras

1992 • 395 citations

Regulation of T-cell responses by CNS antigen-presenting cells: different roles for microglia and astrocytes

2000 • 393 citations

Spectrum of human immunodeficiency virus–associated neocortical damage

1992 • 369 citations

Perivascular Macrophages Are the Primary Cell Type Productively Infected by Simian Immunodeficiency Virus in the Brains of Macaques

2001 • 365 citations

Bone marrow derived elements and resident microglia in brain inflammation

1993 • 352 citations

Expression of Ia antigen on perivascular and microglial cells after sublethal and lethal motor neuron injury

1989 • 289 citations

Identity of ED2‐positive perivascular cells in rat brain

1989 • 281 citations

Intravenous lipopolysaccharide induces cyclooxygenase 2-like immunoreactivity in rat brain perivascular microglia and meningeal macrophages

1997 • 279 citations

Cellular localization of the chemokine receptor CCR5. Correlation to cellular targets of HIV-1 infection.

1997 • 267 citations

Detection of MHC class II-antigens on macrophages and microglia, but not on astrocytes and endothelia in active multiple sclerosis lesions

1994 • 258 citations

Human immunodeficiency virus encephalitis is the pathological correlate of dementia in acquired immunodeficiency syndrome

1994 • 230 citations

Characterization of microglia and macrophages in the central nervous system of rats: Definition of the differential expression of molecules using standard and novel monoclonal antibodies in normal CNS and in four models of parenchymal reaction

1993 • 224 citations

New expression of myelomonocytic antigens by microglia and perivascular cells following lethal motor neuron injury

1990 • 213 citations

The role of macrophages, perivascular cells, and microglial cells in the pathogenesis of experimental autoimmune encephalomyelitis

1995 • 213 citations

The Costimulatory Molecule B7 is Expressed on Human Microglia in Culture and in Multiple Sclerosis Acute Lesions

1995 • 205 citations

Microglial cells are a component of the perivascular glia limitans

1991 • 203 citations

Role of cervical lymph nodes in the systemic humoral immune response to human serum albumin microinfused into rat cerebrospinal fluid

1989 • 193 citations

Peripheral nerve lesion produces increased levels of major histocompatibility complex antigens in the central nervous system

1989 • 189 citations

Male Donor-derived Cells in the Brains of Female Sex-mismatched Bone Marrow Transplant Recipients

1993 • 184 citations

Early viral replication in the brain of SIV-infected rhesus monkeys.

1991 • 184 citations

Graft-vs.-host disease elicits expression of class I and class II histocompatibility antigens and the presence of scattered T lymphocytes in rat central nervous system.

1987 • 178 citations

Involvement of specific macrophage-lineage cells surrounding arterioles in barrier and scavenger function in brain cortex.

1996 • 178 citations

Perivascular cells act as scavengers in the cerebral perivascular spaces and remain distinct from pericytes, microglia and macrophages

1993 • 174 citations

Reactive microglia in multiple sclerosis lesions have an increased expression of receptors for the Fc part of IgG

1994 • 167 citations

B7/BB‐1 antigen expression on adult human microglia studied in vitro and in situ

1994 • 167 citations

Heterogeneity of microglial and perivascular cell populations: Insights gained from the facial nucleus paradigm

1993 • 162 citations

Biology of Adult Human Microglia in Culture: Comparisons with Peripheral Blood Monocytes and Astrocytes

1992 • 162 citations

Neuroinvasion by simian immunodeficiency virus coincides with increased numbers of perivascular macrophages/microglia and intrathecal immune activation

1996 • 149 citations

Psychomotor slowing in HIV infection: A predictor of dementia, AIDS and death

1996 • 148 citations

Ultrastructural Location of Major Histocompatibility Complex (MHC) Class II Positive Perivascular Cells in Histologically Normal Human Brain

1992 • 148 citations

Chemokine receptor expression on resident and inflammatory cells in the brain of macaques with simian immunodeficiency virus encephalitis.

1998 • 148 citations

Human Immunodeficiency Virus-Associated Dementia

1999 • 144 citations

Fc Receptors for IgG on Cultured Human Microglia Mediate Cytotoxicity and Phagocytosis of Antibody-coated Targets

1994 • 133 citations

Monocyte subpopulations in human gliomas: expression of Fc and complement receptors and correlation with tumor proliferation

1990 • 131 citations

Early events in tissues during infection with pathogenic (SIVmac239) and nonpathogenic (SIVmac1A11) molecular clones of simian immunodeficiency virus.

1994 • 128 citations

Absence of donor-type major histocompatibility complex class I antigen-bearing microglia in the rat central nervous system of radiation bone marrow chimeras

1987 • 123 citations

Demonstration of interleukin-1β in Lewis rat brain during experimental allergic encephalomyelitis by immunocytochemistry at the light and ultrastructural level

1993 • 119 citations

Phenotypic Differences between Human Monocytes/Macrophages and Microglial Cells StudiedIn SituandIn Vitro

1994 • 118 citations

Simian immunodeficiency virus encephalitis in Rhesus Macaques is associated with rapid disease progression

1998 • 107 citations

Immunohistochemical Changes and PCR Detection of HIV Provirus DNA in Brains of Asymptomatic HIV-Positive Patients

1994 • 94 citations

Allografts of CNS tissue possess a blood-brain barrier

1991 • 85 citations

HLA class II molecules (HLA-DR, -DP, -DQ) on cells in the human CNS studied in situ and in vitro.

1994 • 83 citations

Macrophage Apoptosis in the Central Nervous System in Experimental Autoimmune Encephalomyelitis

1994 • 77 citations

Bone marrow-derived elements in the peripheral nervous system. An immunohistochemical and ultrastructural investigation in chimeric rats.

1993 • 77 citations

Human Immunodeficiency Virus (HIV) Distribution in HIV Encephalitis: Study of 19 Cases with Combined Use ofIn SituHybridization and Immunocytochemistry

1994 • 72 citations

Increased Apoptosis of T Lymphocytes and Macrophages in the Central and Peripheral Nervous Systems of Lewis Rats with Experimental Autoimmune Encephalomyelitis Treated with Dexamethasone

1997 • 69 citations

Quantitation of Perivascular Monocytes and Macrophages around Cerebral Blood Vessels of Hypertensive and Aged Rats

1994 • 55 citations

Early intrathecal events in rhesus macaques (Macaca mulatta) infected with pathogenic or nonpathogenic molecular clones of simian immunodeficiency virus.

1995 • 54 citations

Allografts of CNS tissue possess a blood‐brain barrier: III. Neuropathological, methodological, and immunological considerations

1994 • 54 citations

Monocyte‐mediated entry of pathogens into the central nervous system

1990 • 44 citations

Long-lasting perivascular accumulation of major histocompatibility complex class II-positive lipophages in the spinal cord of stroke patients: possible relevance for the immune privilege of the brain

1997 • 42 citations

ED2-positive perivascular cells act as neuronophages during delayed neuronal loss in the facial nucleus of the rat

1996 • 39 citations

Evidence for the possible function of the fluorescent granular perithelial cells in brain as scavengers of high-molecular-weight waste products

1984 • 39 citations

The origin of lipid phagocytes in the central nervous system: II. The adventitia of blood vessels

1982 • 39 citations

A quantitative immunohistochemical comparison of actively versus adoptively induced experimental allergic encephalomyelitis in the Lewis rat

1987 • 36 citations

Immunology of central nervous system tumors

1989 • 35 citations

Serological determinants of fluorescent granular perithelial cells along small cerebral blood vessels in rodent

1986 • 33 citations

Studies on fluorescent granular perithelium (F.G.P.) of rat cerebral cortex - especially referring to morphological changes in aging.

1981 • 31 citations

Quantitative electron microscopic observations on the non‐neuronal cells and lipid droplets in the posterior funiculus of the cat after dorsal rhizotomy

1985 • 25 citations

Peripheral nervous system lesions in experimental allergic encephalomyelitis

1986 • 24 citations

Ultrastructural and immunohistochemical changes of fluorescent granular perithelial cells and the interaction of FGP cells to microglia after lipopolysaccharide administration

1998 • 12 citations