Neuroinvasion by simian immunodeficiency virus coincides with increased numbers of perivascular macrophages/microglia and intrathecal immune activation

Detection of AIDS Virus in Macrophages in Brain Tissue from AIDS Patients with Encephalopathy

1986 • 1,694 citations

Perivascular Microglial Cells of the CNS Are Bone Marrow-Derived and Present Antigen in Vivo

1988 • 1,451 citations

T‐lymphocyte entry into the central nervous system

1991 • 1,168 citations

Isolation of HTLV-III from Cerebrospinal Fluid and Neural Tissues of Patients with Neurologic Syndromes Related to the Acquired Immunodeficiency Syndrome

1985 • 1,103 citations

Preferential Migration of Activated CD4 ⁺ and CD8 ⁺ T Cells in Response to MIP-1α and MIP-1β

1993 • 737 citations

Turnover of resident microglia in the normal adult mouse brain

1992 • 679 citations

QUINOLINIC ACID AND KYNURENINE PATHWAY METABOLISM IN INFLAMMATORY AND NON-INFLAMMATORY NEUROLOGICAL DISEASE

1992 • 655 citations

Quinolinic acid in cerebrospinal fluid and serum in HIV‐1 Infection: Relationship to clinical and neurological status

1991 • 563 citations

Cytokines and arachidonic metabolites produced during human immunodeficiency virus (HIV)-infected macrophage-astroglia interactions: implications for the neuropathogenesis of HIV disease.

1992 • 531 citations

Induction of AIDS in rhesus monkeys by molecularly cloned simian immunodeficiency virus

1992 • 496 citations

Macrophages and the Nervous System

1991 • 429 citations

Bone marrow derived elements and resident microglia in brain inflammation

1993 • 352 citations

A Trojan Horse mechanism for the spread of visna virus in monocytes

1985 • 340 citations

The acute inflammatory response to lipopolysaccharide in cns parenchyma differs from that in other body tissues

1992 • 322 citations

Mechanisms for the transendothelial migration of HIV-1-infected monocytes into brain.

1996 • 321 citations

Macrophage inflammatory protein-1 alpha. A novel chemotactic cytokine for macrophages in rheumatoid arthritis.

1994 • 304 citations

HIV antigen in the brains of patients with the AIDS dementia complex

1987 • 289 citations

Human immunodeficiency virus type 1 infection alters chemokine beta peptide expression in human monocytes: implications for recruitment of leukocytes into brain and lymph nodes.

1996 • 288 citations

AIDS subacute encephalitis. Identification of HIV-infected cells.

1987 • 286 citations

Immunopathogenic events in acute infection of rhesus monkeys with simian immunodeficiency virus of macaques

1994 • 251 citations

Early viral replication in the brain of SIV-infected rhesus monkeys.

1991 • 184 citations

Localization of simian immunodeficiency virus in the central nervous system of rhesus monkeys.

1991 • 177 citations

Intracerebral injection of proinflammatory cytokines or leukocyte chemotaxins induces minimal myelomonocytic cell recruitment to the parenchyma of the central nervous system.

1992 • 156 citations

Primary Acute Simian Immunodeficiency Virus Infection of Intestinal Lymphoid Tissue Is Associated with Gastrointestinal Dysfunction

1994 • 145 citations

Immunization with a live, attenuated simian immunodeficiency virus (SIV) prevents early disease but not infection in rhesus macaques challenged with pathogenic SIV

1990 • 136 citations

Macrophage-tropic variants of SIV are associated with specific AIDS-related lesions but are not essential for the development of AIDS.

1991 • 133 citations

Early events in tissues during infection with pathogenic (SIVmac239) and nonpathogenic (SIVmac1A11) molecular clones of simian immunodeficiency virus.

1994 • 128 citations

Quantification of quinolinic acid in rat brain, whole blood, and plasma by gas chromatography and negative chemical ionization mass spectrometry: Effects of systemic l-tryptophan administration on brain and blood quinolinic acid concentrations

1988 • 126 citations

Elevated vascular cell adhesion molecule-1 in AIDS encephalitis induced by simian immunodeficiency virus.

1992 • 126 citations

Simian Immunodeficiency Virus/Delta-Induced Immunodeficiency Disease in Rhesus Monkeys: Relation of Antibody Response and Antigenemia

1988 • 117 citations

Monocyte adhesion to endothelium in simian immunodeficiency virus-induced AIDS encephalitis is mediated by vascular cell adhesion molecule-1/alpha 4 beta 1 integrin interactions.

1994 • 101 citations

Viral determinants of simian immunodeficiency virus (SIV) virulence in rhesus macaques assessed by using attenuated and pathogenic molecular clones of SIVmac

1993 • 91 citations

Genetic and Biological Comparisons of Pathogenic and Nonpathogenic Molecular Clones of Simian Immunodeficiency Virus (SIV_MAC)

1992 • 91 citations

Rhesus Macaques Inoculated With Molecularly Cloned Simian Immunodeficiency Virus

1989 • 83 citations

Simian immunodeficiency virus (SIV)-specific CTL in cerebrospinal fluid and brains of SIV-infected rhesus macaques.

1995 • 66 citations

Transfer of neuropathogenic simian immunodeficiency virus with naturally infected microglia.

1995 • 65 citations

Isolation Frequency of Human Immunodeficiency Virus from Cerebrospinal Fluid and Blood of Patients with Varying Severity of HIV Infection

1988 • 64 citations

Recruitment of lymphocytes during cutaneous delayed hypersensitivity in nonhuman primates is dependent on E-selectin and vascular cell adhesion molecule 1.

1994 • 61 citations

Human immunodeficiency virus infection in microglia: Correlation between cells infected in the brain and cells cultured from infectious brain tissue

1992 • 59 citations

Early intrathecal events in rhesus macaques (Macaca mulatta) infected with pathogenic or nonpathogenic molecular clones of simian immunodeficiency virus.

1995 • 54 citations

(18O)quinolinic acid: Its esterification without back exchange for use as internal standard in the quantification of brain and CSF quinolinic acid

1988 • 47 citations

VCAM‐1 expression and leukocyte trafficking to the CNS occur early in infection with pathogenic isolates of SIV

1995 • 37 citations

Low susceptibility of resident microglia to simian immunodeficiency virus replication during the early stages of infection

1995 • 11 citations