Cardioprotective and Vasodilatory Actions of Glucagon-Like Peptide 1 Receptor Are Mediated Through Both Glucagon-Like Peptide 1 Receptor–Dependent and –Independent Pathways

Measurement of protein using bicinchoninic acid

1985 • 17,516 citations

Biology of Incretins: GLP-1 and GIP

2007 • 3,315 citations

The biology of incretin hormones

2006 • 2,029 citations

Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV.

1995 • 1,064 citations

Effects of Glucagon-Like Peptide-1 in Patients With Acute Myocardial Infarction and Left Ventricular Dysfunction After Successful Reperfusion

2004 • 894 citations

Expression cloning of the pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1.

1992 • 880 citations

Glucagon-like peptide-1 receptor is involved in learning and neuroprotection

2003 • 788 citations

Glucose intolerance but normal satiety in mice with a null mutation in the glucagon–like peptide 1 receptor gene

1996 • 771 citations

Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo.

1995 • 741 citations

Glucagon-Like Peptide-1 Infusion Improves Left Ventricular Ejection Fraction and Functional Status in Patients With Chronic Heart Failure

2006 • 647 citations

Glucagon-like Peptide 1 Can Directly Protect the Heart Against Ischemia/Reperfusion Injury

2005 • 623 citations

Glucagon-like Peptide-1 Receptor Signaling Modulates β Cell Apoptosis

2002 • 583 citations

Tissue distribution of messenger ribonucleic acid encoding the rat glucagon-like peptide-1 receptor.

1996 • 569 citations

Recombinant Glucagon-Like Peptide-1 Increases Myocardial Glucose Uptake and Improves Left Ventricular Performance in Conscious Dogs With Pacing-Induced Dilated Cardiomyopathy

2004 • 506 citations

Effect of Single Oral Doses of Sitagliptin, a Dipeptidyl Peptidase-4 Inhibitor, on Incretin and Plasma Glucose Levels after an Oral Glucose Tolerance Test in Patients with Type 2 Diabetes

2006 • 500 citations

International Union of Pharmacology. XXXV. The Glucagon Receptor Family

2003 • 486 citations

Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons

2002 • 472 citations

Tissue‐specific expression of the human receptor for glucagon‐like peptide‐I: brain, heart and pancreatic forms have the same deduced amino acid sequences

1995 • 425 citations

Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons

2002 • 408 citations

Divergent tissue-specific and developmental expression of receptors for glucagon and glucagon-like peptide-1 in the mouse.

1994 • 321 citations

Double Incretin Receptor Knockout (DIRKO) Mice Reveal an Essential Role for the Enteroinsular Axis in Transducing the Glucoregulatory Actions of DPP-IV Inhibitors

2004 • 300 citations

Direct Effects of Glucagon-Like Peptide-1 on Myocardial Contractility and Glucose Uptake in Normal and Postischemic Isolated Rat Hearts

2006 • 291 citations

Active metabolite of GLP-1 mediates myocardial glucose uptake and improves left ventricular performance in conscious dogs with dilated cardiomyopathy

2005 • 273 citations

Receptor gene expression of glucagon-like peptide-1, but not glucose-dependent insulinotropic polypeptide, in rat nodose ganglion cells

2004 • 268 citations

Biologic actions and therapeutic potential of the proglucagon-derived peptides

2005 • 227 citations

Gluco-incretins control insulin secretion at multiple levels as revealed in mice lacking GLP-1 and GIP receptors

2004 • 223 citations

Gluco-incretins control insulin secretion at multiple levels as revealed in mice lacking GLP-1 and GIP receptors

2004 • 214 citations

Cardiac Function in Mice Lacking the Glucagon-Like Peptide-1 Receptor

2003 • 194 citations

Glucagon-Like Peptide-1 Increases cAMP but Fails to Augment Contraction in Adult Rat Cardiac Myocytes

2001 • 181 citations

Role of Endogenous Glucagon-Like Peptide-1 in Islet Regeneration After Partial Pancreatectomy

2003 • 180 citations

Changes in arterial blood pressure and heart rate induced by glucagon-like peptide-1-(7-36) amide in rats

1994 • 179 citations

High Potency Antagonists of the Pancreatic Glucagon-like Peptide-1 Receptor

1997 • 173 citations

Cardiovascular Effects of the 3 Phosphodiesterase-5 Inhibitors Approved for the Treatment of Erectile Dysfunction

2004 • 173 citations

Vasorelaxant effect of glucagon-like peptide-(7-36)amide and amylin on the pulmonary circulation of the rat

2001 • 163 citations

Both amidated and nonamidated forms of glucagon-like peptide I are synthesized in the rat intestine and the pancreas.

1990 • 154 citations

Attenuation of myocardial ischemia/reperfusion injury in mice with myocyte-specific overexpression of endothelial nitric oxide synthase

2002 • 134 citations

Glucagon-Like Peptide-1 Limits Myocardial Stunning following Brief Coronary Occlusion and Reperfusion in Conscious Canines

2004 • 130 citations

Glucagon Like Peptide-1 is Protective Against Myocardial Ischemia/Reperfusion Injury when Given Either as a Preconditioning Mimetic or at Reperfusion in an Isolated Rat Heart Model

2005 • 122 citations

Molecular evolution of proglucagon

2001 • 92 citations

Glucagon and Glucagon-Like Peptide Receptors as Drug Targets

2006 • 90 citations

Effects of age, gender, and blood pressure on myogenic responses of mesenteric arteries from C57BL/6 mice

2002 • 82 citations

Distribution of GLP‐1 and PACAP receptors in human tissues

1996 • 75 citations

Mouse pancreatic beta-cells exhibit preserved glucose competence after disruption of the glucagon-like peptide-1 receptor gene.

1998 • 72 citations

Bioactive peptides from lizard venoms

1996 • 72 citations

Dietary approaches to positively influence fetal determinants of adult health

2005 • 56 citations

Calcineurin-independent regulation of plasma membrane Ca²⁺ ATPase-4 in the vascular smooth muscle cell cycle

2003 • 54 citations

Regulation of glucose transporters and hexose uptake in 3T3-L1 adipocytes: glucagon-like peptide-1 and insulin interactions

1997 • 48 citations

Local, exendin-(9—39)-insensitive, site of action of GLP-1 in canine ileum

2002 • 21 citations