Phosphorylation of Ser19 Alters the Conformation of Tyrosine Hydroxylase to Increase the Rate of Phosphorylation of Ser40

A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids

1984 • 3,959 citations

Accurate quantitation of protein expression and site-specific phosphorylation

1999 • 1,014 citations

Phosphorylation and Activation of p70 ^s6k by PDK1

1998 • 835 citations

Activation Mechanism of the MAP Kinase ERK2 by Dual Phosphorylation

1997 • 724 citations

Intricate Regulation of Tyrosine Hydroxylase Activity and Gene Expression

1996 • 673 citations

Tetrahydropterin-Dependent Amino Acid Hydroxylases

1999 • 502 citations

Formation of protein kinase recognition sites by covalent modification of the substrate. Molecular mechanism for the synergistic action of casein kinase II and glycogen synthase kinase 3.

1987 • 357 citations

ERK1 and ERK2, two microtubule-associated protein 2 kinases, mediate the phosphorylation of tyrosine hydroxylase at serine-31 in situ.

1992 • 263 citations

Crystal structure of tyrosine hydroxylase at 2.3 Å and its implications for inherited neurodegenerative diseases

1997 • 252 citations

A new activator protein that activates tryptophan 5-monooxygenase and tyrosine 3-monooxygenase in the presence of Ca2+-, calmodulin-dependent protein kinase. Purification and characterization.

1981 • 234 citations

Ordered multisite protein phosphorylation. Analysis of glycogen synthase kinase 3 action using model peptide substrates.

1990 • 158 citations

Tyrosine hydroxylase in rat brain dopaminergic nerve terminals. Multiple-site phosphorylation in vivo and in synaptosomes.

1991 • 155 citations

Site-directed mutagenesis of serine 40 of rat tyrosine hydroxylase. Effects of dopamine and cAMP-dependent phosphorylation on enzyme activity.

1992 • 149 citations

Phosphorylation Sites in the Autoinhibitory Domain Participate in p70s6k Activation Loop Phosphorylation

1998 • 135 citations

Comparative quantification and identification of phosphoproteins using stable isotope labeling and liquid chromatography/mass spectrometry

2000 • 108 citations

Stimulus-Coupled Interaction of Tyrosine Hydroxylase with 14-3-3 Proteins

1999 • 96 citations

Soluble tyrosine hydroxylase (tyrosine 3-monooxygenase) from bovine adrenal medulla: Large-scale purification and physicochemical properties

1988 • 84 citations

Effects of Phosphorylation of Serine 40 of Tyrosine Hydroxylase on Binding of Catecholamines: Evidence for a Novel Regulatory Mechanism

1998 • 77 citations

Interaction of phosphorylated tyrosine hydroxylase with 14‐3‐3 proteins: evidence for a phosphoserine 40‐dependent association

2001 • 71 citations

Role of Serine‐19 Phosphorylation in Regulating Tyrosine Hydroxylase Studied with Site‐ and Phosphospecific Antibodies and Site‐Directed Mutagenesis

1998 • 66 citations

Expression and characterization of catalytic and regulatory domains of rat tyrosine hydroxylase

1993 • 64 citations

Delineation of the catalytic core of phenylalanine hydroxylase and identification of glutamate 286 as a critical residue for pterin function.

1994 • 51 citations

Two Developmentally Regulated Isoenzymes of Calmodulin‐Stimulated Protein Kinase II in Rat Forebrain

1988 • 48 citations

Regulation of recombinant rat tyrosine hydroxylase by dopamine.

1992 • 46 citations

Tyrosine hydroxylase phosphorylation in bovine adrenal chromaffin cells: the role of MAPKs after angiotensin II stimulation

2001 • 43 citations

Limited Proteolysis of Tyrosine Hydroxylase Identifies Residues 33–50 as Conformationally Sensitive to Phosphorylation State and Dopamine Binding

1999 • 38 citations

Tyrosine Hydroxylase Phosphorylation in Bovine Adrenal Chromaffin Cells: The Role of Intracellular Ca²⁺ in the Histamine H₁ Receptor‐Stimulated Phosphorylation of Ser⁸, Ser¹⁹, Ser³¹, and Ser⁴⁰

1995 • 36 citations

Thermal Denaturation of Native Striatal Tyrosine Hydroxylase: Increased Thermolability of the Phosphorylated Form of the Enzyme

1981 • 35 citations

Tyrosine Hydroxylase in Bovine Adrenal Chromaffin Cells: Angiotensin II‐Stimulated Activity and Phosphorylation of Ser¹⁹, Ser³¹, and Ser⁴⁰

1998 • 33 citations

Simultaneous measurement of tyrosine hydroxylase activity and phosphorylation in bovine adrenal chromaffin cells

1999 • 22 citations

Observations on the quantitation of the phosphate content of peptides by fast-atom bombardment mass spectrometry

1987 • 20 citations

Identification of Gln³¹³ and Pro³²⁷ as Residues Critical for Substrate Inhibition in Tyrosine Hydroxylase

1996 • 20 citations

Plasma desorption mass spectrometry of phosphopeptides: An investigation to determine the feasibility of quantifying the degree of phosphorylation

1991 • 12 citations

Autonomous activity and autophosphorylation of CAMPK‐II in rat hippocampal slices: effects of tissue preparation

2001 • 9 citations

Determination of Phosphorylation Levels of Tyrosine Hydroxylase by Electrospray Mass Spectrometry

2000 • 8 citations