Molecular biology of glutathione peroxidase 4: from genomic structure to developmental expression and neural function

Characterization of Mammalian Selenoproteomes

2003 • 2,241 citations

Oxidative stress in neurodegeneration: cause or consequence?

2004 • 1,803 citations

A protein related to extracellular matrix proteins deleted in the mouse mutant reeler

1995 • 1,720 citations

Reactive Astrocytes Protect Tissue and Preserve Function after Spinal Cord Injury

2004 • 1,499 citations

Tissue-specific functions of individual glutathione peroxidases

1999 • 1,115 citations

Leukocyte Infiltration, Neuronal Degeneration, and Neurite Outgrowth after Ablation of Scar-Forming, Reactive Astrocytes in Adult Transgenic Mice

1999 • 1,071 citations

Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury

2006 • 891 citations

Dual Function of the Selenoprotein PHGPx During Sperm Maturation

1999 • 887 citations

Thioredoxin —a fold for all reasons

1995 • 799 citations

Purification from pig liver of a protein which protects liposomes and biomembranes from peroxidative degradation and exhibits glutathione peroxidase activity on phosphatidylcholine hydroperoxides

1982 • 779 citations

HEMOGLOBIN CATABOLISM

1957 • 774 citations

The selenoprotein GPX4 is essential for mouse development and protects from radiation and oxidative damage insults

2003 • 722 citations

Reelin and brain development

2003 • 713 citations

The Refined Structure of the Selenoenzyme Glutathione Peroxidase at 0.2‐nm Resolution

1983 • 676 citations

Mice Deficient in Cellular Glutathione Peroxidase Develop Normally and Show No Increased Sensitivity to Hyperoxia

1997 • 558 citations

Protective action of phospholipid hydroperoxide glutathione peroxidase against membrane-damaging lipid peroxidation. In situ reduction of phospholipid and cholesterol hydroperoxides.

1990 • 516 citations

Peroxide detoxification by brain cells

2004 • 447 citations

Mice with a Homozygous Null Mutation for the Most Abundant Glutathione Peroxidase, Gpx1, Show Increased Susceptibility to the Oxidative Stress-inducing Agents Paraquat and Hydrogen Peroxide

1998 • 445 citations

A novel RNA binding protein, SBP2, is required for the translation of mammalian selenoprotein mRNAs

2000 • 381 citations

Role of reactive oxygen species and cardiolipin in the release of cytochrome c from mitochondria

2003 • 376 citations

Selenium and brain function: a poorly recognized liaison

2004 • 342 citations

Phospholipid hydroperoxide glutathione peroxidase.

1986 • 337 citations

Early embryonic lethality caused by targeted disruption of the mouse PHGPx gene

2003 • 335 citations

Mitochondrial Phospholipid Hydroperoxide Glutathione Peroxidase Suppresses Apoptosis Mediated by a Mitochondrial Death Pathway

1999 • 285 citations

The Nuclear Form of Phospholipid Hydroperoxide Glutathione Peroxidase Is a Protein Thiol Peroxidase Contributing to Sperm Chromatin Stability

2005 • 254 citations

Regulation of enzymatic lipid peroxidation: the interplay of peroxidizing and peroxide reducing enzymes1 1This article is part of a series of reviews on “Regulatory and Cytoprotective Aspects of Lipid Hydroperoxide Metabolism.” The full list of papers may be found on the homepage of the journal.

2002 • 248 citations

Probing the Presumed Catalytic Triad of Selenium-Containing Peroxidases by Mutational Analysis of Phospholipid Hydroperoxide Glutathione Peroxidase (PHGPx)

1995 • 247 citations

Transgenic Mice Overexpressing Glutathione Peroxidase 4 Are Protected against Oxidative Stress-induced Apoptosis

2004 • 246 citations

Apolipoprotein E Receptor-2 (ApoER2) Mediates Selenium Uptake from Selenoprotein P by the Mouse Testis

2007 • 222 citations

[47] Phospholipid hydroperoxide glutathione peroxidase

1990 • 220 citations

Rat Phospholipid-hydroperoxide Glutathione Peroxidase

1995 • 198 citations

Selenoenzymes regulate the activity of leukocyte 5-lipoxygenase via the peroxide tone.

1993 • 196 citations

The Selenoenzyme Phospholipid Hydroperoxide Glutathione Peroxidase Controls the Activity of the 15-Lipoxygenase with Complex Substrates and Preserves the Specificity of the Oxygenation Products

1996 • 189 citations

Selenium deficiency increases susceptibility to glutamate‐induced excitotoxicity

2002 • 174 citations

Deletion of Apolipoprotein E Receptor-2 in Mice Lowers Brain Selenium and Causes Severe Neurological Dysfunction and Death When a Low-Selenium Diet Is Fed

2007 • 170 citations

[20] Enzymatic and immunological measurements of soluble and membrane-bound phospholipid-hydroperoxide glutathione peroxidase

1994 • 169 citations

Protein tyrosine nitration in mouse peritoneal macrophages activated in vitro and in vivo: evidence against an essential role of peroxynitrite

2001 • 167 citations

Bcl-xL Functions Downstream of Caspase-8 to Inhibit Fas- and Tumor Necrosis Factor Receptor 1-induced Apoptosis of MCF7 Breast Carcinoma Cells

1998 • 160 citations

The crystal structure of seleno-glutathione peroxidase from human plasma at 2.9 Å resolution

1997 • 158 citations

Selenium regulation of transcript abundance and translational efficiency of glutathione peroxidase-1 and -4 in rat liver

2001 • 132 citations

Phospholipid hydroperoxide glutathione peroxidase: specific activity in tissues of rats of different age and comparison with other glutathione peroxidases

1989 • 131 citations

Distinct Promoters Determine Alternative Transcription of gpx-4 into Phospholipid-Hydroperoxide Glutathione Peroxidase Variants

2003 • 124 citations

Import into Mitochondria of Phospholipid Hydroperoxide Glutathione Peroxidase Requires a Leader Sequence

1996 • 122 citations

The Thioredoxin Specificity of Drosophila GPx: A Paradigm for a Peroxiredoxin-like Mechanism of many Glutathione Peroxidases

2006 • 121 citations

Identification of a Novel Putative Non-selenocysteine Containing Phospholipid Hydroperoxide Glutathione Peroxidase (NPGPx) Essential for Alleviating Oxidative Stress Generated from Polyunsaturated Fatty Acids in Breast Cancer Cells

2004 • 119 citations

Selenoprotein deficiency and high levels of selenium compounds can effectively inhibit hepatocarcinogenesis in transgenic mice

2005 • 117 citations

Insight into Mammalian Selenocysteine Insertion: Domain Structure and Ribosome Binding Properties of Sec Insertion Sequence Binding Protein 2

2001 • 113 citations

Glutathione peroxidase revisited--simulation of the catalytic cycle by computer-assisted molecular modelling.

1997 • 111 citations

Reconsidering the evolution of eukaryotic selenoproteins: a novel nonmammalian family with scattered phylogenetic distribution

2004 • 110 citations

Essential Role of the Apolipoprotein E Receptor-2 in Sperm Development

2003 • 107 citations

Reduction of HDL- and LDL-Associated Cholesterylester and Phospholipid Hydroperoxides by Phospholipid Hydroperoxide Glutathione Peroxidase and Ebselen (PZ-51)

1994 • 106 citations

Regulation of selenoprotein GPx4 expression and activity in human endothelial cells by fatty acids, cytokines and antioxidants

2003 • 103 citations

Versatility of Selenium Catalysis in PHGPx Unraveled by LC/ESI-MS/MS

2003 • 103 citations

Catalysis of Electron Transfer by Selenocysteine

2006 • 98 citations

Role for glutathione peroxidase-4 in brain development and neuronal apoptosis: Specific induction of enzyme expression in reactive astrocytes following brain injury

2007 • 98 citations

The Role of Phospholipid Hydroperoxide Glutathione Peroxidase Isoforms in Murine Embryogenesis

2006 • 91 citations

Functional Interaction of Phospholipid Hydroperoxide Glutathione Peroxidase with Sperm Mitochondrion-associated Cysteine-rich Protein Discloses the Adjacent Cysteine Motif as a New Substrate of the Selenoperoxidase

2005 • 91 citations

Glutathione peroxidase 4 protects cortical neurons from oxidative injury and amyloid toxicity

2006 • 90 citations

Expression and regulation of antioxidant enzymes in the developing limb support a function of ROS in interdigital cell death

2006 • 74 citations

Distribution of glutathione peroxidases glutathione reductase in rat brain mitochondria

1991 • 73 citations

3’UTRs of Glutathione Peroxidases Differentially Affect Selenium-Dependent mRNA Stability and Selenocysteine Incorporation Efficiency

2003 • 73 citations

Testis-Specific Expression of the Nuclear Form of Phospholipid Hydroperoxide Glutathione Peroxidase (PHGPx)

2003 • 70 citations

Murine phospholipid hydroperoxide glutathione peroxidase: cDNA sequence, tissue expression, and mapping

1999 • 62 citations

Functions of GI‐GPx: Lessons from selenium‐dependent expression and intracellular localization

2001 • 60 citations

Regulation of Expression of the Phospholipid Hydroperoxide/Sperm Nucleus Glutathione Peroxidase Gene

2003 • 59 citations

Structural Organization of the Human Selenium-Dependent Phospholipid Hydroperoxide Glutathione Peroxidase Gene (GPX4): Chromosomal Localization to 19p13.3

1998 • 56 citations

Cloning and sequencing of the mouse cDNA encoding a phospholipid hydroperoxide glutathione peroxidase

1997 • 43 citations

Enzymatic and immunochemical evaluation of phospholipid hydroperoxide glutathione peroxidase (PHGPx) in testes and epididymal spermatozoa of rats of different ages

2002 • 40 citations

Differential Transcriptional Control of the Superoxide Dismutase-2 κB Element in Neurons and Astrocytes

2006 • 39 citations

Functional characterization of cis- and trans-regulatory elements involved in expression of phospholipid hydroperoxide glutathione peroxidase

2003 • 38 citations

Differential Splicing of the Phospholipid Hydroperoxide Glutathione Peroxidase Gene in Diploid and Haploid Male Germ Cells in the Rat1

2003 • 35 citations

The CCAAT‐box binding factor NF‐Y is required for the expression of phospholipid hydroperoxide glutathione peroxidase in human epidermoid carcinoma A431 cells

1999 • 33 citations

A deficit in astroglial organization causes the impaired reactive sprouting in human apolipoprotein E4 targeted replacement mice

2005 • 33 citations

Probing the presumed catalytic triad of a selenium-containing peroxidase by mutational analysis.

1998 • 32 citations

Identification of the Positive Regulatory and Distinct Core Regions of Promoters, and Transcriptional Regulation in Three Types of Mouse Phospholipid Hydroperoxide Glutathione Peroxidase

2006 • 29 citations

Cell-specific Regulation of TRBP1 Promoter by NF-Y Transcription Factor in Lymphocytes and Astrocytes

2005 • 28 citations

The expression of the human neuronal α3 Na+,K+-ATPase subunit gene is regulated by the activity of the Sp1 and NF-Y transcription factors

2005 • 26 citations

cAMP-response element modulator-τ activates a distinct promoter element for the expression of the phospholipid hydroperoxide/sperm nucleus glutathione peroxidase gene

2004 • 25 citations

Discovery of a Functional Retrotransposon of the Murine Phospholipid Hydroperoxide Glutathione Peroxidase: Chromosomal Localization and Tissue-Specific Expression Pattern

2002 • 23 citations

Bacterial and Nonbacterial Expression of Wild-Type and Mutant Human Phospholipid Hydroperoxide Glutathione Peroxidase and Purification of the Mutant Enzyme in the Milligram Scale

2000 • 10 citations