Physical mapping of the cystic fibrosis region by pulsed-field gel electrophoresis

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Methods in Enzymology , Vol

1966 • 26,261 citations

Genomic sequencing.

1984 • 8,343 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1984 • 4,899 citations

CpG-rich islands and the function of DNA methylation

1986 • 3,760 citations

A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma

1986 • 2,968 citations

Separation of yeast chromosome-sized DNAs by pulsed field gradient gel electrophoresis

1984 • 2,847 citations

Separation of Large DNA Molecules by Contour-Clamped Homogeneous Electric Fields

1986 • 1,525 citations

Isolation of candidate cDNAs for portions of the Duchenne muscular dystrophy gene

1986 • 1,033 citations

Electrophoretic Separations of Large DNA Molecules by Periodic Inversion of the Electric Field

1986 • 920 citations

Separation of chromosomal DNA molecules from yeast by orthogonal-field-alternation gel electrophoresis

1984 • 887 citations

Cloning the gene for an inherited human disorder—chronic granulomatous disease—on the basis of its chromosomal location

1986 • 839 citations

Altered Regulation of Airway Epithelial Cell Chloride Channels in Cystic Fibrosis

1986 • 568 citations

Localization of cystic fibrosis locus to human chromosome 7cen–q22

1985 • 498 citations

Cystic Fibrosis Locus Defined by a Genetically Linked Polymorphic DNA Marker

1985 • 488 citations

A closely linked genetic marker for cystic fibrosis

1985 • 463 citations

Chloride and potassium channels in cystic fibrosis airway epithelia

1986 • 392 citations

[28] Purification, specific fragmentation, and separation of large DNA molecules

1987 • 349 citations

A candidate for the cystic fibrosis locus isolated by selection for methylation-free islands

1987 • 339 citations

New Techniques for Purifying Large DNAs and Studying Their Properties and Packaging

1983 • 274 citations

Directional cloning of DNA fragments at a large distance from an initial probe: a circularization method.

1984 • 260 citations

An electrophoretic karyotype forSchizosaccharomyces pombeby pulsed field gel electrophoresis

1987 • 206 citations

Reverse genetics and human disease

1986 • 196 citations

Construction of a General Human Chromosome Jumping Library, with Application to Cystic Fibrosis

1987 • 195 citations

Genetic analysis of the proximal portion of the mouse t complex: Evidence for a second inversion within t haplotypes

1986 • 193 citations

Molecular analysis of the Duchenne muscular dystrophy region using pulsed field gel electrophoresis

1987 • 171 citations

Linkage of cystic fibrosis to two tightly linked DNA markers: joint report from a collaborative study.

1986 • 165 citations

A physical map of 4 million bp around the Duchenne muscular dystrophy gene on the human X-chromosome

1986 • 152 citations

Construction and use of human chromosome jumping libraries from NotI-digested DNA

1987 • 145 citations

Analysis of Genome Organization and Rearrangements by Pulsed Field Gradient Gel Electrophoresis

1986 • 136 citations

A highly polymorphic locus in human DNA revealed by cosmid-derived probes.

1985 • 134 citations

Jumping libraries and linking libraries: the next generation of molecular tools in mammalian genetics

1986 • 131 citations

Megabase-Scale Mapping of the HLA Gene Complex by Pulsed Field Gel Electrophoresis

1987 • 126 citations

Long-range restriction map around the Duchenne muscular dystrophy gene

1986 • 120 citations

[35] Strategies for mapping and cloning macroregions of mammalian genomes

1987 • 112 citations

Textbook of cystic fibrosis

1984 • 76 citations

Refined linkage map of chromosome 7 in the region of the cystic fibrosis gene.

1988 • 59 citations

Chromosome mediated gene transfer of six DNA markers linked to the cystic fibrosis locus on human chromosome seven

1986 • 47 citations

The William Allan Memorial Award address: Reverse genetics and beyond.

1984 • 46 citations

The deletion in both common types of hereditary persistence of fetal hemoglobin is approximately 105 kilobases

1987 • 45 citations

Three additional DNA polymorphisms in the met gene and D7S8 locus: Use in prenatal diagnosis of cystic fibrosis

1987 • 31 citations

Ramped field inversion gel electrophoresis: a cautionary note

1987 • 29 citations

Construction of Human Genetic Linkage Maps: I. Progress and Perspectives

1986 • 18 citations