Diffuse amyloid deposition, but not plaque number, is reduced in amyloid precursor protein/presenilin 1 double-transgenic mice by pathway lesions
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References (70)
Neuropathological stageing of Alzheimer-related changes
1991 • 14,533 citations
Alzheimer's Disease: Genes, Proteins, and Therapy
2001 • 5,919 citations
Inflammation and Alzheimer's disease
2000 • 4,315 citations
Neurodegenerative Tauopathies
2001 • 2,276 citations
Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: Evidence that an initially deposited species is Aβ42(43)
1994 • 1,700 citations
Prevalence of Alzheimer's disease in a community population of older persons. Higher than previously reported
1989 • 1,630 citations
Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In Vivo
1996 • 1,467 citations
Amyloid, the presenilins and Alzheimer's disease
1997 • 1,370 citations
Inflammation in Neurodegenerative Disease—A Double-Edged Sword
2002 • 1,167 citations
Prevalence of Alzheimer's Disease in a Community Population of Older Persons
1989 • 1,128 citations
Intraneuronal Aβ42 Accumulation in Human Brain
2000 • 955 citations
Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport.
1990 • 735 citations
Perforant pathway changes and the memory impairment of Alzheimer's disease
1986 • 665 citations
Amyloid precursor protein processing and Aβ 42 deposition in a transgenic mouse model of Alzheimer disease
1997 • 624 citations
Cerebral amyloid deposition and diffuse plaques in ``normal'' aging
1996 • 600 citations
Kinesin-mediated axonal transport of a membrane compartment containing β-secretase and presenilin-1 requires APP
2001 • 581 citations
TGF-β1 promotes microglial amyloid-β clearance and reduces plaque burden in transgenic mice
2001 • 576 citations
MUTANT GENES IN FAMILIAL ALZHEIMER'S DISEASE AND TRANSGENIC MODELS
1998 • 576 citations
Axonal Transport of Amyloid Precursor Protein Is Mediated by Direct Binding to the Kinesin Light Chain Subunit of Kinesin-I
2000 • 544 citations
Evolution of neuronal changes in the course of Alzheimer’s disease
1998 • 481 citations
Analysis of Heterogeneous βA4 Peptides in Human Cerebrospinal Fluid and Blood by a Newly Developed Sensitive Western Blot Assay
1996 • 477 citations
Prominent neurodegeneration and increased plaque formation in complement-inhibited Alzheimer's mice
2002 • 434 citations
The Presenilins in Alzheimer's Disease--Proteolysis Holds the Key
1999 • 395 citations
Connections between the retrosplenial cortex and the hippocampal formation in the rat: A review
1992 • 383 citations
A Novel ε-Cleavage within the Transmembrane Domain of the Alzheimer Amyloid Precursor Protein Demonstrates Homology with Notch Processing
2002 • 349 citations
Alzheimer's disease affects limbic nuclei of the thalamus
1991 • 316 citations
The entorhinal cortex of the mouse: Organization of the projection to the hippocampal formation
2002 • 312 citations
Evidence That Synaptically Released β-Amyloid Accumulates as Extracellular Deposits in the Hippocampus of Transgenic Mice
2002 • 298 citations
A variety of cerebral amyloid deposits in the brains of the Alzheimer-type dementia demonstrated by? protein immunostaining
1988 • 280 citations
The subiculum: a review of form, physiology and function
2001 • 278 citations
The morphological phenotype of β-amyloid plaques and associated neuritic changes in Alzheimer’s disease
2001 • 266 citations
Alzheimer Amyloid Protein Precursor in the Rat Hippocampus: Transport and Processing through the Perforant Path
1998 • 263 citations
The role of cortical connectivity in Alzheimer's disease pathogenesis: A review and model system
1993 • 251 citations
Full-length amyloid-beta (1-42(43)) and amino-terminally modified and truncated amyloid-beta 42(43) deposit in diffuse plaques.
1996 • 245 citations
Microglial chemotaxis, activation, and phagocytosis of amyloid β-peptide as linked phenomena in Alzheimer's disease
2001 • 232 citations
Axonal and transneuronal transport in the transmission of neurological disease: Potential role in system degenerations, including alzheimer's disease
1987 • 231 citations
Chapter 37 Selective vulnerability of corticocortical and hippocampal circuits in aging and Alzheimer's disease
2002 • 229 citations
Spectrum of morphological appearance of amyloid deposits in Alzheimer's disease
1989 • 219 citations
Amyloid-Associated Neuron Loss and Gliogenesis in the Neocortex of Amyloid Precursor Protein Transgenic Mice
2002 • 206 citations
Amyloid Phenotype Characterization of Transgenic Mice Overexpressing both Mutant Amyloid Precursor Protein and Mutant Presenilin 1 Transgenes
1999 • 188 citations
Reinnervation of the hippocampal perforant pathway zone in Alzheimer's disease
1987 • 176 citations
Transgenic mouse models of Alzheimer's disease
2001 • 175 citations
Subtypes and differential laminar distributions of ?A4 deposits in Alzheimer's disease: relationship with the intellectual status of 26 cases
1991 • 165 citations
The amyloid precursor protein of Alzheimer’s disease and the Aβ peptide
1999 • 160 citations
Projections from the laterodorsal nucleus of the thalamus to the limbic and visual cortices in the rat
1992 • 147 citations
Morphology and distribution of plaque and related deposits in the brains of Alzheimer's disease and control cases. An immunohistochemical study using amyloid beta-protein antibody.
1989 • 143 citations
Disruption of Corticocortical Connections Ameliorates Amyloid Burden in Terminal Fields in a Transgenic Model of Aβ Amyloidosis
2002 • 121 citations
3D-Reconstruction of microglia and amyloid in APP23 transgenic mice: no evidence of intracellular amyloid
2001 • 117 citations
Hippocampal Aβ42 Levels Correlate with Spatial Memory Deficit in APP and PS1 Double Transgenic Mice
2002 • 114 citations
Amyloid beta protein deposition in normal aging has the same characteristics as that in Alzheimer's disease. Predominance of A beta 42(43) and association of A beta 40 with cored plaques.
1996 • 109 citations
Synaptic plasticity and functional stabilization in the hippocampal formation: possible role in Alzheimer's disease.
1988 • 108 citations
Stereologic assessment of the total cortical volume occupied by amyloid deposits and its relationship with cognitive status in aging and Alzheimer’s disease
2002 • 107 citations
LRP and senile plaques in Alzheimer’s disease: colocalization with apolipoprotein E and with activated astrocytes
2002 • 87 citations
Alterations in ApoE and ApoJ in Relation to Degeneration and Regeneration in a Mouse Model of Entorhinal Cortex Lesion
2001 • 86 citations
A direct demonstration of the perforant pathway terminal zone in Alzheimer's disease using the monoclonal antibody Alz-50
1988 • 84 citations
An ‘anatomical cascade hypothesis’ for Alzheimer's disease
1992 • 77 citations
Diffuse, Lake-like Amyloid-β Deposits in the Parvopyramidal Layer of the Presubiculum in Alzheimer Disease
1998 • 68 citations
Transgenic animals relevant to Alzheimer’s disease
1999 • 65 citations
Changes in serum dopamine-beta-hydroxylase activity during cold pressor test in subjects with high and low basal activity of this enzyme
1982 • 62 citations
Hippocampal atrophy secondary to entorhinal cortical degeneration in Alzheimer-type dementia
1997 • 52 citations
The Effects of Long-Term Treatment with Metrifonate, a Cholinesterase Inhibitor, on Cholinergic Activity, Amyloid Pathology, and Cognitive Function in APP and PS1 Doubly Transgenic Mice
2002 • 52 citations
Selective deposition of amyloid-? protein in the entorhinal-dentate projection of a transgenic mouse model of alzheimer's disease
1998 • 44 citations
Cellular and molecular basis of b-amyloid precursor protein metabolism (Y2K update)
2000 • 38 citations
Rapid, Reliable and Economical Silver Stain for Neurofibrillary Tangles and Senile Plaques
1991 • 36 citations
Proteolytical processing of mutated human amyloid precursor protein in transgenic mice
1997 • 35 citations
Transgenic mice expressing the human presenilin 1 gene demonstrate enhanced hippocampal reorganization following entorhinal cortex lesions
2002 • 28 citations
Laminar spongiosis of the dentate gyrus: a sign of disconnection, present in cases of severe Alzheimer's disease
1998 • 23 citations
Statistical aspects of quantitative image analysis of β-amyloid in the APPV717F transgenic mouse model of Alzheimer's disease
2001 • 15 citations
CELLULAR AND MOLECULAR BASIS OF β-AMYLOID PRECURSOR PROTEIN METABOLISM
2000 • 7 citations
Interactions of Aβ with Endogenous Anti-Inflammatory Agents: A Basis for Chronic Neuroinflammation in Alzheimer's Disease
2002 • 7 citations