Emergence of ghrelin as a treatment for cachexia syndromes

Ghrelin is a growth-hormone-releasing acylated peptide from stomach

1999 • 8,261 citations

Wasting as independent risk factor for mortality in chronic heart failure

1997 • 1,373 citations

Cachexia in cancer patients

2002 • 953 citations

Mortality and Cancer Incidence in Acromegaly: A Retrospective Cohort Study¹

1998 • 824 citations

Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT

2002 • 734 citations

Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor

2004 • 699 citations

Orexigenic Action of Peripheral Ghrelin Is Mediated by Neuropeptide Y and Agouti-Related Protein

2004 • 662 citations

Deletion of Ghrelin Impairs neither Growth nor Appetite

2003 • 631 citations

Co-Localization of Growth Hormone Secretagogue Receptor and NPY mRNA in the Arcuate Nucleus of the Rat

1999 • 592 citations

Effects of Ghrelin Administration on Left Ventricular Function, Exercise Capacity, and Muscle Wasting in Patients With Chronic Heart Failure

2004 • 515 citations

Biology of Cachexia

1997 • 486 citations

Inflammation, Malnutrition, and Cardiac Disease as Predictors of Mortality in Hemodialysis Patients

2002 • 484 citations

Antagonism of ghrelin receptor reduces food intake and body weight gain in mice

2003 • 480 citations

Chronic Administration of Ghrelin Improves Left Ventricular Dysfunction and Attenuates Development of Cardiac Cachexia in Rats With Heart Failure

2001 • 475 citations

Ghrelin Increases Energy Intake in Cancer Patients with Impaired Appetite: Acute, Randomized, Placebo-Controlled Trial

2004 • 457 citations

Elevated Circulating Level of Ghrelin in Cachexia Associated With Chronic Heart Failure

2001 • 432 citations

Hyperphagic Effects of Brainstem Ghrelin Administration

2003 • 299 citations

Treatment of Cachexia With Ghrelin in Patients With COPD

2005 • 294 citations

Increased plasma ghrelin level in lung cancer cachexia.

2003 • 283 citations

Plasma Ghrelin and Desacyl Ghrelin Concentrations in Renal Failure

2002 • 273 citations

Active Ghrelin Levels and Active to Total Ghrelin Ratio in Cancer-Induced Cachexia

2005 • 249 citations

Pharmacokinetics, safety, and endocrine and appetite effects of ghrelin administration in young healthy subjects

2004 • 219 citations

Ghrelin and Des-Acyl Ghrelin Promote Differentiation and Fusion of C2C12 Skeletal Muscle Cells

2007 • 210 citations

Subcutaneous Ghrelin Enhances Acute Food Intake in Malnourished Patients Who Receive Maintenance Peritoneal Dialysis

2005 • 207 citations

Ghrelin Treatment Causes Increased Food Intake and Retention of Lean Body Mass in a Rat Model of Cancer Cachexia

2007 • 177 citations

Anti-inflammatory effect of the ghrelin agonist growth hormone-releasing peptide-2 (GHRP-2) in arthritic rats

2004 • 168 citations

Safety, tolerability and pharmacokinetics of intravenous ghrelin for cancer-related anorexia/cachexia: a randomised, placebo-controlled, double-blind, double-crossover study

2008 • 156 citations

Anti-cachectic effect of ghrelin in nude mice bearing human melanoma cells

2003 • 154 citations

GH-Releasing Peptide-2 Increases Fat Mass in Mice Lacking NPY: Indication for a Crucial Mediating Role of Hypothalamic Agouti-Related Protein

2002 • 151 citations

Ghrelin Treatment of Chronic Kidney Disease: Improvements in Lean Body Mass and Cytokine Profile

2007 • 142 citations

Elevated Plasma Ghrelin Level in Underweight Patients with Chronic Obstructive Pulmonary Disease

2004 • 141 citations

Ghrelin Prevents Cisplatin-Induced Mechanical Hyperalgesia and Cachexia

2007 • 116 citations

Ghrelin alleviates cancer chemotherapy-associated dyspepsia in rodents

2006 • 88 citations

Mortality and Cancer Incidence in Acromegaly: A Retrospective Cohort Study

1999 • 75 citations

Effects of ghrelin on anorexia in tumor-bearing mice with eicosanoid-related cachexia

2006 • 73 citations

GH-releasing peptides improve cardiac dysfunction and cachexia and suppress stress-related hormones and cardiomyocyte apoptosis in rats with heart failure

2005 • 71 citations

Cachexia: lessons from melanocortin antagonism

2006 • 53 citations

A phase II randomized, placebo-controlled, double-blind study of the efficacy and safety of RC-1291 (RC) for the treatment of cancer cachexia

2007 • 52 citations

Ghrelin stimulates growth hormone secretion and food intake in aged rats

2006 • 37 citations

Ghrelin stimulates food intake and growth hormone release in rats with thermal injury: Synthesis of ghrelin

2006 • 34 citations

Melanocortin interventions in cachexia: how soon from bench to bedside?

2007 • 23 citations

Involvement of Ghrelin-Growth Hormone Secretagogue Receptor System in Pathoclinical Profiles of Digestive System Cancer

2007 • 20 citations