Identifying Unfolding Intermediates of FN-III10 by Steered Molecular Dynamics

VMD: Visual molecular dynamics

1996 • 54,630 citations

Comparison of simple potential functions for simulating liquid water

1983 • 37,746 citations

Particle mesh Ewald: An N⋅log(N) method for Ewald sums in large systems

1993 • 26,634 citations

All-Atom Empirical Potential for Molecular Modeling and Dynamics Studies of Proteins

1998 • 13,827 citations

Constant pressure molecular dynamics simulation: The Langevin piston method

1995 • 4,126 citations

X-PLOR Version 3.1: A System for X-ray Crystallography and NMR

1992 • 3,488 citations

NAMD2: Greater Scalability for Parallel Molecular Dynamics

1999 • 2,396 citations

Transmembrane crosstalk between the extracellular matrix and the cytoskeleton

2001 • 2,141 citations

Mechanical and chemical unfolding of a single protein: A comparison

1999 • 1,022 citations

Steered molecular dynamics and mechanical functions of proteins

2001 • 1,002 citations

The molecular elasticity of the extracellular matrix protein tenascin

1998 • 835 citations

Mechanical unfolding intermediates in titin modules

1999 • 796 citations

Unfolding of Titin Immunoglobulin Domains by Steered Molecular Dynamics Simulation

1998 • 692 citations

2.0 Å Crystal Structure of a Four-Domain Segment of Human Fibronectin Encompassing the RGD Loop and Synergy Region

1996 • 621 citations

The Mechanical Hierarchies of Fibronectin Observed with Single-molecule AFM

2002 • 396 citations

Fibronectin extension and unfolding within cell matrix fibrils controlled by cytoskeletal tension

2002 • 355 citations

Forced unfolding of fibronectin type 3 modules: an analysis by biased molecular dynamics simulations

1999 • 338 citations

Stretching single molecules into novel conformations using the atomic force microscope.

2000 • 307 citations

Unfolding proteins by external forces and temperature: The importance of topology and energetics

2000 • 296 citations

Reversible unfolding of fibronectin type III and immunoglobulin domains provides the structural basis for stretch and elasticity of titin and fibronectin.

1994 • 294 citations

The Key Event in Force-Induced Unfolding of Titin’s Immunoglobulin Domains

2000 • 284 citations

Forced unfolding of the fibronectin type III module reveals a tensile molecular recognition switch

1999 • 269 citations

Can Non-Mechanical Proteins Withstand Force? Stretching Barnase by Atomic Force Microscopy and Molecular Dynamics Simulation

2001 • 232 citations

Dynamics and elasticity of the fibronectin matrix in living cell culture visualized by fibronectin–green fluorescent protein

1999 • 222 citations

Point mutations alter the mechanical stability of immunoglobulin modules.

2000 • 214 citations

Fibronectin's III-1 module contains a conformation-dependent binding site for the amino-terminal region of fibronectin.

1994 • 204 citations

Formation of amyloid-like fibrils by self-association of a partially unfolded fibronectin type III module

1998 • 201 citations

Coexisting conformations of fibronectin in cell culture imaged using fluorescence resonance energy transfer

2001 • 188 citations

Native topology determines force-induced unfolding pathways in globular proteins

2000 • 173 citations

A structural model for force regulated integrin binding to fibronectin's RGD-synergy site

2002 • 167 citations

Steered molecular dynamics simulation of conformational changes of immunoglobulin domain I27 interprete atomic force microscopy observations

1999 • 156 citations

A novel role for the integrin-binding III-10 module in fibronectin matrix assembly.

1996 • 133 citations

The inclusion of the type III repeat ED-B in the fibronectin molecule generates conformational modifications that unmask a cryptic sequence.

1992 • 127 citations

Comparison of the early stages of forced unfolding for fibronectin type III modules

2001 • 126 citations

A comparison of the folding kinetics and thermodynamics of two homologous fibronectin type III modules

1997 • 123 citations

Cryptic Self-association Sites in Type III Modules of Fibronectin

1997 • 113 citations

A novel fibronectin binding site required for fibronectin fibril growth during matrix assembly

2001 • 113 citations

Fibronectin Fibrillogenesis Involves the Heparin II Binding Domain of Fibronectin

1998 • 96 citations

The folding nucleus of a fibronectin type III domain is composed of core residues of the immunoglobulin-like fold

2001 • 89 citations

Structural insights into the mechanical regulation of molecular recognition sites

2001 • 84 citations

Unfolding Forces of Titin and Fibronectin Domains Directly Measured by AFM

2000 • 78 citations

Conformational Analysis of Native Fibronectin by Means of Force Spectroscopy

2000 • 73 citations

Interactions Between Type III Domains in the 110 kDa Cell-binding Fragment of Fibronectin

1995 • 56 citations

Simulated Refolding of Stretched Titin Immunoglobulin Domains

2001 • 56 citations