Techniques for encapsulating bioactive agents into liposomes

Production of large unilamellar vesicles by a rapid extrusion procedure. Characterization of size distribution, trapped volume and ability to maintain a membrane potential

1985 • 2,037 citations

Phosphatidylcholine vesicles. Formation and physical characteristics

1969 • 1,522 citations

Partial Resolution of the Enzymes Catalyzing Oxidative Phosphorylation

1971 • 1,364 citations

Preparation of liposomes of defined size distribution by extrusion through polycarbonate membranes

1979 • 1,085 citations

Phospholipid vesicle formation and transmembrane protein incorporation using octyl glucoside

1981 • 678 citations

Reconstitution and Purification of the D-Glucose Transport Protein from Human Erythrocytes

1977 • 652 citations

Effect of the cholesterol content of small unilamellar liposomes on their stability in vivo and in vitro

1980 • 585 citations

Preparation and Use of Liposomes as Models of Biological Membranes

1974 • 567 citations

Liposomes from ionic, single-chain amphiphiles

1978 • 562 citations

Reconstitution and purification of the D-glucose transporter from human erythrocytes.

1977 • 558 citations

Large volume liposomes by an ether vaporization method

1976 • 515 citations

Solute distributions and trapping efficiencies observed in freeze-thawed multilamellar vesicles

1985 • 429 citations

Liposomal Amphotericin B for the Treatment of Systemic Fungal Infections in Patients with Cancer: A Preliminary Study

1985 • 412 citations

Drug entrapment in liposomes

1973 • 405 citations

Single bilayer vesicles prepared without sonication physico-chemical properties

1976 • 381 citations

Uptake of adriamycin into large unilamellar vesicles in response to a pH gradient

1986 • 363 citations

Phospholipid model membranes. II. Permeability properties of hydrated liquid crystals

1967 • 359 citations

Generation of multilamellar and unilamellar phospholipid vesicles

1986 • 346 citations

Liposomes with a large trapping capacity prepared by freezing and thawing of sonicated phospholipid mixtures

1981 • 342 citations

Preservation of freeze-dried liposomes by trehalose

1985 • 340 citations

Fate of Protein‐Containing Liposomes Injected into Rats

1972 • 339 citations

Treatment and Prophylaxis of Disseminated Infection Due to Candida albicans in Mice with Liposome-Encapsulated Amphotericin B

1983 • 300 citations

Liposomes as in vivo carriers of adriamycin: reduced cardiac uptake and preserved antitumor activity in mice.

1982 • 260 citations

Lysosomal localization of β-fructofuranosidase-containing liposomes injected into rats. Some implications in the treatment of genetic disorders

1972 • 257 citations

Tissue distribution of liposomes exhibiting long half-lives in the circulation after intravenous injection

1985 • 252 citations

Disintegration of phosphatidylcholine liposomes in plasma as a result of interaction with high-density lipoproteins

1978 • 248 citations

Liposome disposition in vivo

1981 • 227 citations

Liposome targeting in vivo: Problems and opportunities

1983 • 220 citations

Treatment of Murine Cryptococcosis with Liposome-Associated Amphotericin B

1982 • 205 citations

Uptake of antineoplastic agents into large unilamellar vesicles in response to a membrane potential

1985 • 186 citations

Novel multilayered lipid vesicles: comparison of physical characteristics of multilamellar liposomes and stable plurilamellar vesicles

1985 • 182 citations

Liposome-mediated delivery of deoxyribonucleic acid to cells: enhanced efficiency of delivery by changes in lipid composition and incubation conditions

1981 • 181 citations

Characterization, toxicity and therapeutic efficacy of adrïamycin encapsulated in liposomes

1982 • 176 citations

Protection of large unilamellar vesicles by trehalose during dehydration: retention of vesicle contents

1985 • 162 citations

Amphotericin B in Liposomes: A Novel Therapy for Histoplasmosis¹

1982 • 157 citations

Liposomes as drug carriers in cancer chemotherapy

1984 • 148 citations

Is half‐life of circulating liposomes determined by changes in their permeability?

1982 • 144 citations

A new method for preparation of phospholipid vesicles (liposomes) ‐ french press

1979 • 142 citations

The phospholipid component of small unilamellar liposomes controls the rate of clearance of entrapped solutes from the circulation

1980 • 134 citations

Catecholamine uptake and concentration by liposomes maintaining pH gradients

1976 • 129 citations

Liposome-Encapsulated Amphotericin B for Treatment of Disseminated Candidiasis in Neutropenic Mice

1984 • 126 citations

Evidence for translation of rabbit globin mRNA after liposomemediated insertion into a human cell line

1978 • 125 citations

Cholesterol content of small unilamellar liposomes controls phospholipid loss to high density lipoproteins in the presence of serum

1980 • 123 citations

Liposome–Collagen Gel Matrix: A Novel Sustained Drug Delivery System

1985 • 120 citations

Pharmacological, toxicological, and therapeutic evaluation in mice of doxorubicin entrapped in cardiolipin liposomes.

1985 • 99 citations

Enzyme replacement via liposomes variations in lipid composition determine liposomal integrity in biological fluids

1979 • 94 citations

Comparison of large unilamellar vesicles prepared by a petroleum ether vaporization method with multilamellar vesicles

1978 • 91 citations

Stability of liposomes on storage: freeze dried, frozen or as an aqueous dispersion.

1984 • 84 citations

Drug delivery systems : characteristics and biomedical applications

1980 • 78 citations

The in vivo transformation of phospholipid vesicles to a particle resembling HDL in the rat

1976 • 77 citations

Liposomes in leishmaniasis: Therapeutic effects of antimonial drugs, 8-aminoquinolines, and tetracycline

1980 • 75 citations

Treatment of Brucella canis and Brucella abortus in Vitro and in Vivo by Stable Plurilamellar Vesicle-Encapsulated Aminoglycosides

1985 • 73 citations

Free Versus Liposome-Entrapped Ampicillin in Treatment of Infection Due to Listeria monocytogenes in Normal and Atbymic (Nude) Mice

1985 • 70 citations

Treatment of experimental salmonellosis in mice with streptomycin entrapped in liposomes

1985 • 57 citations

Liposome Disposition In Vivo VI: Delivery to the Lung

1984 • 55 citations

Uptake of safranine and other lipophilic cations into model membrane systems in response to a membrane potential

1985 • 52 citations

The potential use of liposome-mediated antiviral therapy

1985 • 49 citations

Liposome Disposition in Vivo II: Dose Dependency

1982 • 46 citations

Liposomes as a controlled-release system

1985 • 44 citations

On the size-dependent disintegration of small unilamellar phosphatidylcholine vesicles in rat plasma. Evidence of complete loss of vesicle structure

1984 • 41 citations

Uptake of dibucaine into large unilamellar vesicles in response to a membrane potential.

1985 • 41 citations

Liposomes—Problems and promise as selective drug carriers

1981 • 40 citations

Treatment of experimental murine candidiasis with liposome-associated amphotericin B

1984 • 37 citations

Liposomes Carrying Diatrizoate: Characterization of Biophysical Properties and Imaging Applications

1984 • 36 citations

Carrier Activity of Sonicated Small Liposomes Containing Melphalan to Regional Lymph Nodes of Rats

1983 • 33 citations

A novel method for preparing liposome with a high capacity to encapsulate proteinous drugs: Freeze-drying method.

1984 • 32 citations

Evaluation of a new liposome preparation technique, the freeze-thawing method, using L-asparaginase as a model drug.

1985 • 25 citations

The in vivo release of cortisone esters from liposomes and the intramuscular clearance of liposomes

1984 • 21 citations

Role of lipoproteins in stability and clearance of liposomes administered to mice

1984 • 14 citations