Human Glioma Cells and Undifferentiated Primary Astrocytes That Express Aberrant EAAT2 mRNA Inhibit Normal EAAT2 Protein Expression and Prevent Cell Death

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

Localization of neuronal and glial glutamate transporters

1994 • 1,668 citations

Selective loss of glial glutamate transporter GLT‐1 in amyotrophic lateral sclerosis

1995 • 1,430 citations

Primary structure and functional characterization of a high-affinity glutamate transporter

1992 • 1,319 citations

Cloning and expression of a rat brain L-glutamate transporter

1992 • 1,230 citations

Structure, expression, and functional analysis of a Na(+)-dependent glutamate/aspartate transporter from rat brain.

1992 • 1,185 citations

Decreased Glutamate Transport by the Brain and Spinal Cord in Amyotrophic Lateral Sclerosis

1992 • 1,170 citations

An excitatory amino-acid transporter with properties of a ligand-gated chloride channel

1995 • 1,124 citations

Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex

1994 • 988 citations

Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance

1997 • 909 citations

Aberrant RNA Processing in a Neurodegenerative Disease: the Cause for Absent EAAT2, a Glutamate Transporter, in Amyotrophic Lateral Sclerosis

1998 • 663 citations

Abnormal excitatory amino acid metabolism in amyotrophic lateral sclerosis

1990 • 630 citations

Chronic inhibition of glutamate uptake produces a model of slow neurotoxicity.

1993 • 623 citations

Brain Glutamate Transporter Proteins Form Homomultimers

1996 • 471 citations

Deficient glutamate tranport is associated with neurodegeneration in Alzheimer's disease

1996 • 437 citations

Glutamate Transporter Alterations in Alzheimer Disease Are Possibly Associated with Abnormal APP Expression

1997 • 325 citations

Regulation of the Glial Na⁺-Dependent Glutamate Transporters by Cyclic AMP Analogs and Neurons

1998 • 299 citations

Parvalbumin and calbindin D‐28k in the human motor system and in motor neuron disease

1993 • 279 citations

Modulation of the neuronal glutamate transporter EAAT4 by two interacting proteins

2001 • 241 citations

Glutamate transporter gene expression in amyotrophic lateral sclerosis motor cortex

1996 • 237 citations

Neuronal Soluble Factors Differentially Regulate the Expression of the GLT1 and GLAST Glutamate Transporters in Cultured Astroglia

1997 • 236 citations

Cellular and synaptic localization of the neuronal glutamate transporters excitatory amino acid transporter 3 and 4

1997 • 233 citations

EAAC1, a high-affinity glutamate tranporter, is localized to astrocytes and gabaergic neurons besides pyramidal cells in the rat cerebral cortex

1998 • 225 citations

Modulation of the neuronal glutamate transporter EAAC1 by the interacting protein GTRAP3-18

2001 • 222 citations

Expression of a Variant Form of the Glutamate Transporter GLT1 in Neuronal Cultures and in Neurons and Astrocytes in the Rat Brain

2002 • 205 citations

Methamphetamine causes widespread apoptosis in the mouse brain: evidence from using an improved TUNEL histochemical method

2001 • 197 citations

The GLT‐1 and GLAST Glutamate Transporters Are Expressed on Morphologically Distinct Astrocytes and Regulated by Neuronal Activity in Primary Hippocampal Cocultures

2000 • 186 citations

Gliotoxic Action of Glutamate on Cultured Astrocytes

2000 • 166 citations

A splice variant of glutamate transporter GLT1/EAAT2 expressed in neurons: cloning and localization in rat nervous system

2002 • 153 citations

The RNA of the glutamate transporter EAAT2 is variably spliced in amyotrophic lateral sclerosis and normal individuals

1999 • 128 citations

Motor Neuron Degeneration Induced by Excitotoxin Agonists Has Features in Common with those Seen in the SOD-1 Transgenic Mouse Model of Amyotrophic Lateral Sclerosis

1996 • 114 citations

Mutations in the glutamate transporter EAAT2 gene do not cause abnormal EAAT2 transcripts in amyotrophic lateral sclerosis

1998 • 113 citations

Glutamate transporter EAAC1 is expressed in neurons and glial cells in the rat nervous system

1999 • 109 citations

Glutamate transporter EAAT2 splice variants occur not only in ALS, but also in AD and controls

2000 • 91 citations

Intron Retention Generates a Novel Isoform of the Murine Vitamin D Receptor That Acts in a Dominant Negative Way on the Vitamin D Signaling Pathway

1996 • 82 citations

Identification of alternative splicing forms of GLT-1 mRNA in the spinal cord of amyotrophic lateral sclerosis patients

1998 • 81 citations

In vitro kainate injury to large, SMI-32(+) spinal neurons is Ca2+ dependent

1995 • 77 citations

Intron 7 retention and exon 9 skipping EAAT2 mRNA variants are not associated with amyotrophic lateral sclerosis

2001 • 75 citations

Expression of glutamate uptake transporters after dibutyryl cyclic AMP differentiation and traumatic injury in cultured astrocytes

1997 • 40 citations

A reliable and sensitive method for non-radioactive Northern blot analysis of nerve growth factor mRNA from brain tissues

1995 • 33 citations

Impaired RNA splicing of 5'-regulatory sequences of the astroglial glutamate transporter EAAT2 in human astrocytoma

2001 • 24 citations

L‐Glutamate Suppresses Amyloid β‐Protein‐Induced Stellation of Cultured Rat Cortical Astrocytes

2000 • 20 citations

Most studied single cell

1976 • 2 citations