Opiate alkaloids antagonize postsynaptic glycine and GABA responses: Correlation with convulsant action

Chemical Nature of Synaptic Transmission in Vertebrates

1974 • 1,613 citations

Amino acid transmitters in the mammalian central nervous system

1974 • 1,169 citations

Opiate analgesics inhibit substance P release from rat trigeminal nucleus

1977 • 968 citations

Cortical cellular phenomena in experimental epilepsy: Interictal manifestations

1964 • 838 citations

Bicuculline, an antagonist of GABA and synaptic inhibition in the spinal cord of the cat

1971 • 685 citations

The action of γ-Aminobutyric acid on cortical neurones

1967 • 612 citations

Opioid Peptides May Excite Hippocampal Pyramidal Neurons by Inhibiting Adjacent Inhibitory Interneurons

1979 • 610 citations

Enkephalin inhibits release of substance P from sensory neurons in culture and decreases action potential duration.

1979 • 546 citations

Mouse spinal cord in cell culture. I. Morphology and intrinsic neuronal electrophysiologic properties

1977 • 510 citations

Epilepsy and γ-Aminobutyric Acid-Mediated Inhibition

1975 • 491 citations

Properties of Opiate-Receptor Binding in Rat Brain

1973 • 437 citations

Inhibitory of glycine on spinal neurons in the cat.

1968 • 411 citations

Studies of the uptake of3H-GABA and [3H]glycine in slices and homogenates of rat brain and spinal cord by electron microscopic autoradiography

1972 • 371 citations

Morphine and Enkephalin: Analgesic and Epileptic Properties

1977 • 358 citations

Enkephalin blocks inhibitory pathways in the vertebrate CNS

1980 • 334 citations

Synthetic Analgesics: Stereochemical Considerations

1954 • 331 citations

Naloxone as a GABA antagonist: Evidence from iontophoretic, receptor binding and convulsant studies

1978 • 330 citations

The mechanism of inhibition of neuronal activity by opiates in the spinal cord of cat

1976 • 321 citations

Amino acid pharmacology of mammalian central neurones grown in tissue culture.

1978 • 270 citations

The depolarization shift in “epileptic” neurons

1968 • 268 citations

Opiates and Opioid Peptides Hyperpolarize Locus Coeruleus Neurons in Vitro

1980 • 229 citations

Role of a persistent inward current in motoneuron bursting during spinal seizures.

1980 • 220 citations

Epileptic properties of leucine- and methionine-enkephalin: Comparison with morphine and reversibility by naloxone

1978 • 208 citations

In vitro pharmacology of the opioid peptides, enkephalins and endorphins

1977 • 205 citations

SUPPRESSION OF TRANSMISSION OF NOCICEPTIVE IMPULSES BY MORPHINE: SELECTIVE EFFECTS OF MORPHINE ADMINISTERED IN THE REGION OF THE SUBSTANTIA GELATINOSA

1977 • 195 citations

The effect of bicuculline upon synaptic inhibition in the cerebral and cerebellar cortices of the cat

1971 • 193 citations

Specific antagonism of GABA‐mediated postsynaptic inhibition in cultured mammalian spinal cord neurons

1978 • 191 citations

The effects of methionine- and leucine-enkephalin on spinal neurones of the cat

1979 • 184 citations

Neuronal behavior and triggering mechanism in cortical epileptic focus.

1969 • 166 citations

Specific-Opiate-Induced Depression of Transmitter Release from Dorsal Root Ganglion Cells in Culture

1978 • 163 citations

Different Brain Areas Mediate the Analgesic and Epileptic Properties of Enkephalin

1978 • 158 citations

THE MECHANISM OF ACTION OF NARCOTIC ANALGESICS IN THE GUINEA‐PIG ILEUM

1977 • 130 citations

MORPHINE ADDICTION AND ITS PHYSIOLOGICAL INTERPRETATION BASED ON EXPERIMENTAL EVIDENCES

1929 • 115 citations

Excitatory action of opioid peptides and opiates on cultured hippocampal pyramidal cells

1980 • 97 citations

Effects of enkephalin and morphine on Renshaw cells in feline spinal cord

1976 • 97 citations

Interaction of enkephalin with opiate receptors in intact cultured cells.

1978 • 95 citations

The effects of strychnine on the inhibition of interneurons by glycine and γ-aminobutyric acid

1969 • 94 citations

Anticonvulsants Specific for Petit Mal Antagonize Epileptogenic Effect of Leucine Enkephalin

1980 • 81 citations

The depression of spinal inhibition by morphine

1969 • 66 citations

Morphine Blockade of Amino Acid Putative Transmitters on Cat Spinal Cord Sensory Interneurones

1973 • 66 citations

Multiple membrane actions of enkephalin revealed using cultured spinal neurons

1978 • 52 citations

Opiate agonist-antagonist effects on Renshaw cells and spinal interneurones

1974 • 51 citations

An electrophysiological analysis of the convulsant action of morphine, codeine and thebaine.

1961 • 48 citations

Effects of endorphins on single myenteric neurons

1979 • 48 citations

Rat tissue levels of carbon-14 labeled analgetics as related to pharmacological activity.

1955 • 46 citations

Morphine and enkephalin interactions with putative neurotransmitters in rat hippocampus

1977 • 40 citations

Morphine, naloxone and the responses of medial thalamic neurones of the cat

1977 • 40 citations

Interaction of lontophoretically applied morphine with responses of interneurons in cat spinal cord

1976 • 39 citations

Modulation of synaptosomal GABA release by enkephalin

1980 • 37 citations

SELECTIVE EFFECTS OF MORPHINE ON THE NOCICEPTIVE RESPONSES OF THALAMIC NEURONES IN THE RAT

1978 • 34 citations

The effects of morphine, etorphine and sinomenine on the chemical sensitivity and synaptic responses of Renshaw cells and other spinal neurones in the rat

1974 • 31 citations

Lethality of the morphinan isomers levorphanol and dextrorphan

1973 • 16 citations