Improved reversal learning and altered fear conditioning in transgenic mice with regionally restricted p25 expression

Neuropathological stageing of Alzheimer-related changes

1991 • 14,533 citations

Place navigation impaired in rats with hippocampal lesions

1982 • 6,277 citations

Alzheimer's Disease Is a Synaptic Failure

2002 • 4,102 citations

The isolation of nerve endings from brain: an electron-microscopic study of cell fragments derived by homogenization and centrifugation.

1962 • 2,522 citations

Two‐dimensional electrophoresis. The current state of two‐dimensional electrophoresis with immobilized pH gradients

1988 • 2,431 citations

The current state of two-dimensional electrophoresis with immobilized pH gradients

2000 • 1,498 citations

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

1999 • 1,483 citations

CENTRAL CHOLINERGIC SYSTEMS AND COGNITION

1997 • 1,328 citations

Neurotoxicity induces cleavage of p35 to p25 by calpain

2000 • 1,031 citations

Hyperphosphorylation induces self-assembly of τ into tangles of paired helical filaments/straight filaments

2001 • 889 citations

Severity of spatial learning impairment in aging: Development of a learning index for performance in the Morris water maze.

2015 • 856 citations

Upregulation of choline acetyltransferase activity in hippocampus and frontal cortex of elderly subjects with mild cognitive impairment

2002 • 676 citations

Severity of spatial learning impairment in aging: Development of a learning index for performance in the Morris water maze.

1993 • 653 citations

Hippocampus and contextual fear conditioning: Recent controversies and advances

2001 • 617 citations

Monoclonal antibodies show that neurofibrillary tangles and neurofilaments share antigenic determinants

1982 • 541 citations

CaMKII regulates the frequency-response function of hippocampal synapses for the production of both LTD and LTP

1995 • 530 citations

Lesions of the dorsal hippocampal formation interfere with background but not foreground contextual fear conditioning.

1994 • 527 citations

Regulated phosphorylation and dephosphorylation of tau protein: effects on microtubule interaction, intracellular trafficking and neurodegeneration

1997 • 438 citations

Calpain-dependent Proteolytic Cleavage of the p35 Cyclin-dependent Kinase 5 Activator to p25

2000 • 378 citations

Assessment of learning by the Morris water task and fear conditioning in inbred mouse strains and F1 hybrids: implications of genetic background for single gene mutations and quantitative trait loci analyses

1997 • 351 citations

Spatial memory dissociations in mice lacking GluR1

2002 • 342 citations

Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5

2000 • 336 citations

Regulation of NMDA receptors by cyclin-dependent kinase-5

2001 • 255 citations

Learning and Memory in Transgenic Mice Modeling Alzheimer's Disease

2001 • 224 citations

Deregulation of cdk5, Hyperphosphorylation, and Cytoskeletal Pathology in the Niemann–Pick Type C Murine Model

2002 • 182 citations

A survey of Cdk5 activator p35 and p25 levels in Alzheimer's disease brains

2002 • 180 citations

Neurofilament protein synthesis and phosphorylation.

2000 • 158 citations

Cyclin-Dependent Kinase 5 Is Required for Associative Learning

2002 • 137 citations

Overexpression ofhAPPsweImpairs Rewarded Alternation and Contextual Fear Conditioning in a Transgenic Mouse Model of Alzheimer's Disease

2002 • 133 citations

Hyperphosphorylation and accumulation of neurofilament proteins in Alzheimer disease brain and in okadaic acid‐treated SY5Y cells

2001 • 131 citations

Effect of excitotoxic lesions of rat medial prefrontal cortex on spatial memory

2002 • 111 citations

Axonopathy, tau abnormalities, and dyskinesia, but no neurofibrillary tangles in p25‐transgenic mice

2002 • 99 citations

p25 protein in neurodegeneration

2001 • 80 citations

Involvement of cyclin dependent kinase5 activator p25 on tau phosphorylation in mouse brain

2001 • 78 citations

Cytochalasin Modulation of Nicotinic Cholinergic Receptor Expression and Muscarinic Receptor Function in Human TE671/RD Cells: A Possible Functional Role of the Cytoskeleton

1993 • 45 citations

Increased tau messenger RNA in Alzheimer's disease hippocampus.

1990 • 42 citations

Cleavage of the cyclin-dependent kinase 5 activator p35 to p25 does not induce tau hyperphosphorylation

2002 • 37 citations

Alpha isoform of calciumcalmodulin dependent protein kinase II (CAM II kinase-α) restricted to excitatory synapses in the CA1 region of rat hippocampus

1997 • 33 citations

p25 protein in neurodegeneration

2001 • 23 citations