Multiple mechanisms of regulation of the inositol 1,4,5-trisphosphate receptor by calcium

Inositol trisphosphate and calcium signalling

1993 • 6,546 citations

Bell-shaped calcium-response curves of lns(l,4,5)P3- and calcium-gated channels from endoplasmic reticulum of cerebellum

1991 • 1,699 citations

Differential activation of transcription factors induced by Ca2+ response amplitude and duration

1997 • 1,533 citations

Calcium as a Coagonist of Inositol 1,4,5-Trisphosphate-Induced Calcium Release

1991 • 843 citations

Solubilization, purification, and characterization of an inositol trisphosphate receptor.

1988 • 650 citations

Biphasic Ca2+ dependence of inositol 1,4,5-trisphosphate-induced Ca release in smooth muscle cells of the guinea pig taenia caeci.

1990 • 601 citations

Characterization of inositol trisphosphate receptor binding in brain. Regulation by pH and calcium.

1987 • 551 citations

The sarcoplasmic reticulum Ca2+ channel/ryanodine receptor: modulation by endogenous effectors, drugs and disease states.

1997 • 549 citations

Type I, II, and III Inositol 1,4,5-Trisphosphate Receptors Are Unequally Susceptible to Down-regulation and Are Expressed in Markedly Different Proportions in Different Cell Types

1995 • 418 citations

Vasopressin-, angiotensin II-, and alpha 1-adrenergic-induced inhibition of Ca2+ transport by rat liver plasma membrane vesicles.

1984 • 279 citations

Heterotetrameric Complex Formation of Inositol 1,4,5-Trisphosphate Receptor Subunits

1995 • 214 citations

Minimal requirements for calcium oscillations driven by the IP3 receptor

1997 • 183 citations

Characterization of a membrane protein from brain mediating the inhibition of inositol 1,4,5-trisphosphate receptor binding by calcium

1988 • 168 citations

Molecular and Functional Evidence for Multiple Ca2+-binding Domains in the Type 1 Inositol 1,4,5-Trisphosphate Receptor

1997 • 142 citations

The effect of external calcium and pH on inositol trisphosphate-mediated calcium release from cerebellum microsomal fractions

1989 • 139 citations

The inositol triphosphate receptor family

1996 • 133 citations

The inositol 1,4,5-trisphosphate (InsP3) receptor

1995 • 132 citations

Heteroligomers of Type-I and Type-III Inositol Trisphosphate Receptors in WB Rat Liver Epithelial Cells

1995 • 128 citations

Calcium mediates the interconversion between two states of the liver inositol 1,4,5-trisphosphate receptor.

1990 • 127 citations

Characterization of a Cytosolic and a Luminal Ca2+ Binding Site in the Type I Inositol 1,4,5-Trisphosphate Receptor

1996 • 126 citations

Mechanism of Ca2+ inhibition of inositol 1,4,5-trisphosphate (InsP3) binding to the cerebellar InsP3 receptor.

1992 • 125 citations

Isoform diversity of the inositol trisphosphate receptor in cell types of mouse origin

1997 • 119 citations

Two calcium-binding sites mediate the interconversion of liver inositol 1,4,5-trisphosphate receptors between three conformational states

1994 • 95 citations

Calcium and inositol trisphosphate receptors

1995 • 94 citations

Phosphorylation of the inositol trisphosphate receptor in isolated rat hepatocytes.

1993 • 93 citations

Biphasic effects of cytosolic Ca2+ on Ins(1,4,5)P3-stimulated Ca2+ mobilization in hepatocytes

1993 • 91 citations

Ca2+ differentially regulates the ligand-affinity states of type 1 and type 3 inositol 1,4,5-trisphosphate receptors

1997 • 88 citations

Phosphorylation of the inositol trisphosphate receptor in isolated rat hepatocytes.

1993 • 80 citations

Inositol 1,4,5-Trisphosphate and Calcium Regulate the Calcium Channel Function of the Hepatic Inositol 1,4,5-Trisphosphate Receptor

1997 • 76 citations

Inositol 1,4,5-trisphosphate receptors in Xenopus laevis oocytes: Localization and modulation by Ca2+

1994 • 65 citations

Inositol trisphosphate‐mediated Ca2+ influx into Xenopus oocytes triggers Ca2+ liberation from intracellular stores.

1993 • 59 citations

The inositol 1,4,5-trisphosphate receptor is localized on specialized sub-regions of the endoplasmic reticulum in rat liver

1994 • 59 citations

Kinetics of Calcium Release by Immunoaffinity-purified Inositol 1,4,5-Trisphosphate Receptor in Reconstituted Lipid Vesicles

1995 • 47 citations

Rapid filtration studies of the effect of cytosolic Ca2+ on inositol 1,4,5-trisphosphate-induced 45Ca2+ release from cerebellar microsomes

1994 • 45 citations

IP3 receptor purified from liver plasma membrane is an (1,4,5)IP3 activated and (1,3,4,5)IP4 inhibited calcium permeable ion channel

1995 • 40 citations

Rapid kinetics of myo-inositol trisphosphate binding and dissociation in cerebellar microsomes.

1994 • 39 citations

Micromolar calcium decreases affinity of inositol trisphosphate receptor in vascular smooth muscle

1994 • 38 citations

Ca2+ and Mg2+ regulation of inositol 1,4,5-triphosphate binding in myeloid cells

1993 • 32 citations

Characterization of a rapidly dissociating inositol 1,4,5-trisphosphate-binding site in liver membranes.

1992 • 31 citations

Characterization of the co-agonist effects of strontium and calcium on myo-inositol trisphosphate-dependent ion fluxes in cerebellar microsomes

1995 • 23 citations

Characterizations of two forms of inositol 1,4,5-trisphosphate receptor in rat liver

1990 • 17 citations

[39] Assay and purification of neuronal receptors for inositol 1,4,5-trisphosphate

1992 • 9 citations

The properties of a subtype of the inositol 1,4,5-trisphosphate receptor resulting from alternative splicing of the mRNA in the ligand-binding domain

1996 • 7 citations