To cure chronic HIV infection, a new therapeutic strategy is needed

Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection

1995 • 4,310 citations

Viral dynamics in human immunodeficiency virus type 1 infection

1995 • 3,277 citations

Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome

1994 • 2,529 citations

Interleukin-2: Inception, Impact, and Implications

1988 • 2,166 citations

Counting Antigen-Specific CD8 T Cells: A Reevaluation of Bystander Activation during Viral Infection

1998 • 1,996 citations

Virus-specific CD8+ cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection

1994 • 1,899 citations

Viral Immune Evasion Due to Persistence of Activated T Cells Without Effector Function

1998 • 1,890 citations

Vigorous HIV-1-Specific CD4 ⁺ T Cell Responses Associated with Control of Viremia

1997 • 1,868 citations

Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells

1993 • 1,219 citations

CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infection

1994 • 1,161 citations

T cell growth factor receptors. Quantitation, specificity, and biological relevance

1981 • 1,087 citations

lnterleukin-2 programs mouse αβ T lymphocytes for apoptosis

1991 • 1,027 citations

Immune control of HIV-1 after early treatment of acute infection

2000 • 1,012 citations

MATURE T LYMPHOCYTE APOPTOSIS—Immune Regulation in a Dynamic and Unpredictable Antigenic Environment

1999 • 973 citations

The Interleukin-2 T-Cell System: A New Cell Growth Model

1984 • 935 citations

T‐Cell Growth Factor

1980 • 917 citations

HIV-1 and T cell dynamics after interruption of highly active antiretroviral therapy (HAART) in patients with a history of sustained viral suppression

1999 • 815 citations

Massive Expansion of Antigen-Specific CD8+ T Cells during an Acute Virus Infection

1998 • 794 citations

HIV-1-specific CD4+ T cells are detectable in most individuals with active HIV-1 infection, but decline with prolonged viral suppression

1999 • 766 citations

Induction and Exhaustion of Lymphocytic Choriomeningitis Virus–specific Cytotoxic T Lymphocytes Visualized Using Soluble Tetrameric Major Histocompatibility Complex Class I–Peptide Complexes

1998 • 733 citations

Glucocorticoid-induced inhibition of T cell growth factor production. I. The effect on mitogen-induced lymphocyte proliferation.

1979 • 567 citations

Direct demonstration of cytokine synthesis heterogeneity among human memory/effector T cells by flow cytometry

1995 • 561 citations

Heterogeneity of intracellular cytokine synthesis at the single-cell level in polarized T helper 1 and T helper 2 populations.

1995 • 554 citations

Triggering of the T3-Ti antigen-receptor complex results in clonal T-cell proliferation through an interleukin 2-dependent autocrine pathway.

1984 • 506 citations

Immune Responses in Interleukin-2-Deficient Mice

1993 • 476 citations

An Inquiry into the Causes and Effects of the Variolae Vaccinae A Disease Discovered in Some of the Western Counties of England, Particularly Gloucestershire, and Known by the Name of the Cow Pox

2010 • 390 citations

Cellular Immune Responses and Viral Diversity in Individuals Treated during Acute and Early HIV-1 Infection

2001 • 390 citations

Glucocorticoid-Induced Inhibition of T Cell Growth Factor Production

1979 • 364 citations

Enhanced establishment of a virus carrier state in adult CD4+ T-cell-deficient mice

1994 • 321 citations

Inhibition of Cell Cycle Progression by Rapamycin Induces T Cell Clonal Anergy Even in the Presence of Costimulation

1999 • 288 citations

Glucocorticoid-induced inhibition of T cell growth factor production. II. The effect on the in vitro generation of cytolytic T cells.

1979 • 244 citations

Constant Mean Viral Copy Number per Infected Cell in Tissues Regardless of High, Low, or Undetectable Plasma HIV RNA

1999 • 214 citations

Augmentation of immune responses to HIV-1 and simian immunodeficiency virus DNA vaccines by IL-2/Ig plasmid administration in rhesus monkeys

2000 • 209 citations

Production and characterization of monoclonal antibodies to human interleukin 2: strategy and tactics.

1983 • 203 citations

Heterogeneity of human T-cell growth factor(s) due to variable glycosylation

1981 • 193 citations

The virological and immunological consequences of structured treatment interruptions in chronic HIV-1 infection

2001 • 193 citations

Molecular regulation of interleukin‐2 expression by CD28 co‐stimulation and anergy

1998 • 190 citations

Endogenous IL-2 contributes to T cell expansion and IFN-gamma production during lymphocytic choriomeningitis virus infection.

1995 • 172 citations

The Effect of T Cell Growth Factor on the Generation of Cytolytic T Cells

1978 • 113 citations

Glucocorticoid-Induced Inhibition of T Cell Growth Factor Production

1979 • 110 citations

Update: The Numbers Game for Virus-Specific CD8 ⁺ T Cells

1998 • 91 citations

The role of CD4+ cells in sustaining lymphocyte proliferation during lymphocytic choriomeningitis virus infection.

1991 • 48 citations

Perspectives on inducing efficient immune control of HIV-1 replication - a new goal for HIV therapeutics?

2001 • 21 citations

In Vivo Assessment of Antiviral Reactivity in Chronic HIV Infection

2000 • 8 citations