Molecular modelling and quantitative structure-activity relationship studies on the interaction of omeprazole with cytochrome P450 isozymes

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

1994 • 2,716 citations

Crystal Structure of Hemoprotein Domain of P450BM-3, a Prototype for Microsomal P450's

1993 • 876 citations

Biochemistry and molecular biology of the human CYP2C subfamily

1994 • 534 citations

Reconciling the Magnitude of the Microscopic and Macroscopic Hydrophobic Effects

1991 • 509 citations

Role of Human Cytochromes P450 in the Metabolic Activation of Chemical Carcinogens and Toxins

1994 • 498 citations

Roles of cytochrome P-450 enzymes in chemical carcinogenesis and cancer chemotherapy.

1988 • 465 citations

Texicological studies on omeprazole

1985 • 359 citations

The Pharmacology of the Gastric Acid Pump: The H+,K+ ATPase

1995 • 358 citations

Omeprazole is an aryl hydrocarbon-like inducer of human hepatic cytochrome P450

1990 • 310 citations

Human liver microsomal cytochrome P-450 enzymes involved in the bioactivation of procarcinogens detected by umu gene response in Salmonella typhimurium TA 1535/pSK1002.

1989 • 265 citations

Cytochromes P450: structure, function and mechanism.

1996 • 232 citations

Identification of human liver cytochrome P450 isoforms mediating omeprazole metabolism

1993 • 225 citations

Evaluation of omeprazole and lansoprazole as inhibitors of cytochrome P450 isoforms.

1997 • 208 citations

Toward the semiquantitative estimation of binding constants. Guides for peptide-peptide binding in aqueous solution

1991 • 183 citations

Oxidative metabolism of omeprazole in human liver microsomes: cosegregation with S-mephenytoin 4'-hydroxylation.

1993 • 143 citations

Guide to Cytochromes P450

1996 • 141 citations

Omeprazole and lansoprazole are mixed inducers of CYP1A and CYP3A in human hepatocytes in primary culture.

1994 • 140 citations

Increase of cytochrome P450IA2 activity by omeprazole: Evidence by the 13C-[N-3-methyl]-caffeine breath test in poor and extensive metabolizers of S-mephenytoin

1992 • 138 citations

Induction of Cytochrome P4501 as an Indicator of Potential Chemical Carcinogenesis

1993 • 135 citations

Omeprazole, an inducer of human CYP1A1 and 1A2, is not a ligand for the Ah receptor

1992 • 128 citations

Omeprazole Drug Interaction Studies

1991 • 125 citations

Accelerated caffeine metabolism after omeprazole treatment is indicated by urinary metabolite ratios: Coincidence with plasma clearance and breath test

1994 • 107 citations

Molecular modelling of cytochrome P4502D6 (CYP2D6) based on an alignment with CYP102 : structural studies on specific CYP2D6substrate metabolism

1997 • 93 citations

Human CYP2C19 is a major omeprazole 5-hydroxylase, as demonstrated with recombinant cytochrome P450 enzymes.

1996 • 92 citations

Interaction of human liver cytochromes P450 in vitro with LY307640, a gastric proton pump inhibitor

1996 • 89 citations

Molecular modelling of CYP3A4 from an alignment with CYP102: Identification of key interactions between putative active site residues and CYP3A-specific chemicals

1996 • 88 citations

Specific and dose-dependent enzyme induction by omeprazole in human beings

1994 • 86 citations

Identification of Residues 99, 220, and 221 of Human Cytochrome P450 2C19 as Key Determinants of Omeprazole Hydroxylase Activity

1996 • 85 citations

Molecular modelling of CYP1A subfamily members based on an alignment with CYP102: rationalization of CYP1A substrate specificity in terms of active site amino acid residues

1996 • 83 citations

Three-dimensional models of human and other mammalian microsomal P450s constructed from an alignment with P450102 (P450_bm3)

1995 • 78 citations

Inhibition by omeprazole of proguanil metabolism: mechanism of the interaction in vitro and prediction of in vivo results from the in vitro experiments.

1997 • 77 citations

Molecular modelling of human CYP2C subfamily enzymes CYP2C9 and CYP2C19: rationalization of substrate specificity and site-directed mutagenesis experiments in the CYP2C subfamily

1998 • 59 citations

CYP1A1: Friend or Foe?

1993 • 58 citations

On the Reliability of Calculated Log P‐values: Rekker, Hansch/Leo and Suzuki Approach

1993 • 57 citations

Quantitative Structure-Activity Relationships in Substrates, Inducers, and Inhibitors of Cytochrome P4501 (CYP1)

1997 • 55 citations

Omeprazole and the induction of human cytochrome P-450: A response to concerns about potential adverse effects

1991 • 46 citations

Effects of benzimidazole derivatives on cytochrome P450 1A1 expression in a human hepatoma cell line

1997 • 44 citations

The metabolism of tamoxifen by human cytochromes P450 is rationalized by molecular modelling of the enzyme-substrate interactions: potential importance to its proposed anti-carcinogenic/carcinogenic actions

1996 • 42 citations

A single amino acid substitution confers progesterone 6 beta-hydroxylase activity to rabbit cytochrome P450 2C3.

1993 • 42 citations

Clinical implications of drug interactions with the cytochrome P-450 enzyme system associated with omeprazole

1991 • 40 citations

Human cytochrome P450 isoforms

1990 • 38 citations

Inhibition of human liver cytochrome P‐450 by omeprazole.

1986 • 38 citations

Diazepam–omeprazole inhibition interaction: an <scp>in vitro</scp> investigation using human liver microsomes

1996 • 37 citations

Genotoxicity and cell proliferative activity of omeprazole in rat stomach mucosa

1991 • 35 citations

Alterations of the regiospecificity of progesterone metabolism by the mutagenesis of two key amino acid residues in rabbit cytochrome P450 2C3v.

1994 • 28 citations

The interaction of omeprazole with rat liver cytochrome P450-mediated monooxygenase reactions in vitro and in vivo

1988 • 23 citations

Omeprazole: an exploration of its reported genotoxicity

1991 • 20 citations

Interaction of omeprazole with DNA in rat tissues

1992 • 18 citations

The binding to oxidised cytochromes P-450 and inhibition of mixed-function oxidases by aryl-substituted benzimidazoles and related compounds

1983 • 18 citations

Selectivity of omeprazole inhibition towards rat liver cytochromes P450

1997 • 13 citations

Lack of evidence of omeprazole genotoxicity in Sprague-Dawley rats

1993 • 13 citations

[14] Assays of omeprazole metabolism as a substrate probe for human CYP isoforms

1996 • 13 citations

[11] In vivo and in vitro measurement of CYP2C19 activity

1996 • 12 citations

Consideration of CASE predictions of genotoxic carcinogenesis for omeprazole, methapyrilene and azathioprine

1992 • 11 citations