When kinases meet mathematics: the systems biology of MAPK signalling

Engineering stability in gene networks by autoregulation

2000 • 1,542 citations

Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions

2000 • 1,398 citations

The RAF proteins take centre stage

2004 • 1,158 citations

Self-perpetuating states in signal transduction: positive feedback, double-negative feedback and bistability

2002 • 1,107 citations

The Biochemical Basis of an All-or-None Cell Fate Switch in Xenopus Oocytes

1998 • 1,040 citations

Computational modeling of the dynamics of the MAP kinase cascade activated by surface and internalized EGF receptors

2002 • 966 citations

Molecular interpretation of ERK signal duration by immediate early gene products

2002 • 914 citations

Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP

1999 • 850 citations

Signaling Pathways for PC12 Cell Differentiation: Making the Right Connections

2002 • 788 citations

Regulation of MAP Kinase Signaling Modules by Scaffold Proteins in Mammals

2003 • 766 citations

A positive-feedback-based bistable ‘memory module’ that governs a cell fate decision

2003 • 742 citations

Positive feedback in eukaryotic gene networks: cell differentiation by graded to binary response conversion

2001 • 706 citations

Negative feedback and ultrasensitivity can bring about oscillations in the mitogen‐activated protein kinase cascades

2000 • 656 citations

MAP Kinase Phosphatase As a Locus of Flexibility in a Mitogen-Activated Protein Kinase Signaling Network

2002 • 647 citations

Multicenter Phase II Study of the Oral MEK Inhibitor, CI-1040, in Patients With Advanced Non-Small-Cell Lung, Breast, Colon, and Pancreatic Cancer

2004 • 631 citations

Computational approaches to cellular rhythms

2002 • 575 citations

Scaffold proteins may biphasically affect the levels of mitogen-activated protein kinase signaling and reduce its threshold properties

2000 • 494 citations

Localization of the MP1-MAPK Scaffold Complex to Endosomes Is Mediated by p14 and Required for Signal Transduction

2002 • 375 citations

Computational modeling of the EGF-receptor system: a paradigm for systems biology

2002 • 349 citations

Activation of Raf-1 Signaling by Protein Kinase C through a Mechanism Involving Raf Kinase Inhibitory Protein

2003 • 346 citations

C-TAK1 Regulates Ras Signaling by Phosphorylating the MAPK Scaffold, KSR1

2001 • 277 citations

Differential feedback regulation of the MAPK cascade underlies the quantitative differences in EGF and NGF signalling in PC12 cells

2000 • 248 citations

A computational model on the modulation of mitogen-activated protein kinase (MAPK) and Akt pathways in heregulin-induced ErbB signalling

2003 • 236 citations

Quantitative analysis of signaling networks

2004 • 221 citations

Cyclic AMP-Dependent Kinase Regulates Raf-1 Kinase Mainly by Phosphorylation of Serine 259

2002 • 220 citations

Modelling the Influence of RKIP on the ERK Signalling Pathway Using the Stochastic Process Algebra PEPA

2006 • 217 citations

Negative Feedback Regulation and Desensitization of Insulin- and Epidermal Growth Factor-stimulated p21ras Activation

1995 • 184 citations

Untying the regulation of the Raf-1 kinase

2002 • 174 citations

An Integrated Model of Epidermal Growth Factor Receptor Trafficking and Signal Transduction

2003 • 173 citations

EGF induced SOS phosphorylation in PC12 cells involves P90 RSK-2

1997 • 157 citations

Mitogen-Activated Protein Kinase Feedback Phosphorylation Regulates MEK1 Complex Formation and Activation during Cellular Adhesion

2004 • 135 citations

Modelling the dynamics of the yeast pheromone pathway

2004 • 118 citations

Mathematical Modeling of the Influence of RKIP on the ERK Signaling Pathway

2003 • 98 citations

Stimulus-Coupled Spatial Restriction of Extracellular Signal-Regulated Kinase 1/2 Activity Contributes to the Specificity of Signal-Response Pathways

2004 • 90 citations

Inventing the Negative Feedback Amplifier

1977 • 87 citations

Inventing the negative feedback amplifier: Six years of persistent search helped the author conceive the idea “in a flash” aboard the old Lackawanna Ferry

1977 • 86 citations

Temporal Regulation of Light-Induced Extracellular Signal-Regulated Kinase Activation in the Suprachiasmatic Nucleus

2003 • 61 citations

The origin of hematopoietic cell type diversity

2004 • 55 citations

Targeting MAPK Signalling: Prometheus Fire or Pandoras Box?

2004 • 50 citations

Circadian and photic regulation of MAP kinase by Ras‐ and protein phosphatase‐dependent pathways in the chick pineal gland

2001 • 37 citations

A Spectrum of Models of Signaling Pathways

2004 • 35 citations

Shc‐dependent pathway is redundant but dominant in MAPK cascade activation by EGF receptors: a modeling inference

2003 • 26 citations

Resistance to signal activation governs design features of the MAP kinase signaling module

2003 • 25 citations

Selectivity in Overlapping MAP Kinase Cascades

2002 • 24 citations