The structure of p53 tumour suppressor protein reveals the basis for its functional plasticity

Surfing the p53 network

2000 • 6,487 citations

Crystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations

1994 • 2,460 citations

p53: puzzle and paradigm.

1996 • 2,363 citations

Definition of a consensus binding site for p53

1992 • 2,000 citations

A New Generation of the IMAGIC Image Processing System

1996 • 1,236 citations

Identification of p53 as a Sequence-Specific DNA-Binding Protein

1991 • 1,109 citations

Regulation of the specific DNA binding function of p53

1992 • 914 citations

Cotranslation of activated mutant p53 with wild type drives the wild-type p53 protein into the mutant conformation

1991 • 617 citations

Angular reconstitution: A posteriori assignment of projection directions for 3D reconstruction

1987 • 600 citations

Single-particle electron cryo-microscopy: towards atomic resolution

2000 • 589 citations

Structure of the p53 Tumor Suppressor Bound to the Ankyrin and SH3 Domains of 53BP2

1996 • 569 citations

Exact filters for general geometry three dimensional reconstruction

1986 • 541 citations

Crystal Structure of the Tetramerization Domain of the p53 Tumor Suppressor at 1.7 Angstroms

1995 • 533 citations

p53: traffic cop at the crossroads of DNA repair and recombination

2005 • 529 citations

Three‐Dimensional reconstruction of single particles from random and nonrandom tilt series

1988 • 497 citations

Transcriptional Regulation by p53 through Intrinsic DNA/Chromatin Binding and Site-Directed Cofactor Recruitment

2001 • 437 citations

p53 and its 14 kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches

1995 • 409 citations

Structural Basis of DNA Recognition by p53 Tetramers

2006 • 390 citations

Allosteric activation of latent p53 tetramers

1994 • 302 citations

Single-stranded DNA mimicry in the p53 transactivation domain interaction with replication protein A

2005 • 275 citations

Latent and active p53 are identical in conformation.

2001 • 268 citations

The p53 protein is an unusually shaped tetramer that binds directly to DNA.

1993 • 252 citations

Structure of a Sir2 Enzyme Bound to an Acetylated p53 Peptide

2002 • 232 citations

Refined solution structure of the oligomerization domain of the tumour suppressor p53

1995 • 217 citations

A C-terminal alpha-helix plus basic region motif is the major structural determinant of p53 tetramerization.

1992 • 193 citations

Two Domains of p53 Interact with the TATA-Binding Protein, and the Adenovirus 13S E1A Protein Disrupts the Association, Relieving p53-Mediated Transcriptional Repression

1995 • 185 citations

p53 Linear Diffusion along DNA Requires Its C Terminus

2004 • 184 citations

Crystal structure of human 53BP1 BRCT domains bound to p53 tumour suppressor

2002 • 182 citations

Use of the two-hybrid system to identify the domain of p53 involved in oligomerization.

1993 • 182 citations

p53 tagged sites from human genomic DNA

1994 • 178 citations

Structure of the tetrameric restriction endonuclease NgoMIV in complex with cleaved DNA.

2000 • 167 citations

p53 binds single-stranded DNA ends through the C-terminal domain and internal DNA segments via the middle domain

1995 • 160 citations

p53 Domains: Structure, Oligomerization, and Transformation

1994 • 146 citations

Interaction of p53 with Its Consensus DNA-Binding Site

1995 • 146 citations

Efficient Specific DNA Binding by p53 Requires both Its Central and C-Terminal Domains as Revealed by Studies with High-Mobility Group 1 Protein

2002 • 145 citations

Structure of the p53 Core Domain Dimer Bound to DNA

2006 • 138 citations

Reactivation of Mutant p53 through Interaction of a C-Terminal Peptide with the Core Domain

1999 • 138 citations

p53 oligomerization and DNA looping are linked with transcriptional activation.

1994 • 127 citations

Reciprocal Interference between the Sequence-Specific Core and Nonspecific C-Terminal DNA Binding Domains of p53: Implications for Regulation

1997 • 119 citations

On the fitting of model electron densities into EM reconstructions: a reciprocal-space formulation

2002 • 117 citations

The carboxyl-terminal domain of the p53 protein regulates sequence-specific DNA binding through its nonspecific nucleic acid-binding activity.

1995 • 101 citations

Core domain interactions in full-length p53 in solution

2006 • 89 citations

The Cfr10I restriction enzyme is functional as a tetramer

1999 • 89 citations

p53 domains: structure, oligomerization, and transformation.

1994 • 88 citations

Crystal Structure of the Mouse p53 Core DNA-binding Domain at 2.7 Å Resolution

2001 • 87 citations

Dynamic interactions of p53 with DNA in solution by time-lapse atomic force microscopy

2001 • 86 citations

Identification of an additional negative regulatory region for p53 sequence-specific DNA binding

1998 • 86 citations

Dissection of Functional Domains of the Human DNA Replication Protein Complex Replication Protein A

1996 • 81 citations

Human p53 binds DNA as a protein homodimer but monomeric variants retain full transcription transactivation activity.

1993 • 73 citations

25 Years of p53 Research

2005 • 68 citations

Induced N- and C-terminal cleavage of p53: a core fragment of p53, generated by interaction with damaged DNA, promotes cleavage of the N-terminus of full-length p53, whereas ssDNA induces C-terminal cleavage of p53

1997 • 65 citations

The complex interactions of p53 with target DNA: we learn as we go

2003 • 61 citations

DNA looping by the SfiI restriction endonuclease

1998 • 59 citations

The N Terminus of p53 Regulates Its Dissociation from DNA

2000 • 53 citations

Structural Differences in the DNA Binding Domains of Human p53 and Its C. elegans Ortholog Cep-1

2004 • 52 citations

Principles of organization in S layers

1986 • 49 citations

The N terminus of the murine p53 tumour suppressor is an independent regulatory domain affecting activation and thermostability 1 1Edited by J. Karn

1998 • 36 citations

Synergistic transcriptional activation of the MCK promoter by p53: tetramers link separated DNA response elements by DNA looping

1998 • 36 citations

An ATP/ADP-Dependent Molecular Switch Regulates the Stability of p53-DNA Complexes

1999 • 36 citations

p53 latency – out of the blind alley

2002 • 29 citations