STAT3, but not ERKs, mediates the IL-6–induced proliferation of renal cancer cells, ACHN and 769P

Stat3 as an Oncogene

1999 • 2,770 citations

Mitogen-Activated Protein Kinase: Conservation of a Three-Kinase Module From Yeast to Human

1999 • 2,692 citations

Mitogen-activated protein kinase pathways

1997 • 2,513 citations

The biology of interleukin-6

1989 • 1,964 citations

Maximal activation of transcription by statl and stat3 requires both tyrosine and serine phosphorylation

1995 • 1,960 citations

TRANSCRIPTIONAL RESPONSES TO POLYPEPTIDE LIGANDS: The JAK-STAT Pathway

1995 • 1,826 citations

Constitutive Activation of Stat3 Signaling Confers Resistance to Apoptosis in Human U266 Myeloma Cells

1999 • 1,655 citations

The biology of interleukin-6

1989 • 1,459 citations

Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130

1989 • 1,411 citations

Molecular cloning and expression of an IL-6 signal transducer, gp130

1990 • 1,307 citations

The role of STATs in transcriptional control and their impact on cellular function

2000 • 1,186 citations

Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucleotidyl transferase and nick translation assays.

1993 • 997 citations

Enhanced DNA-Binding Activity of a Stat3-Related Protein in Cells Transformed by the Src Oncoprotein

1995 • 945 citations

Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor

1996 • 915 citations

Two Signals Are Necessary for Cell Proliferation Induced by a Cytokine Receptor gp130: Involvement of STAT3 in Anti-Apoptosis

1996 • 661 citations

The SIF binding element confers sis/PDGF inducibility onto the c-fos promoter.

1990 • 615 citations

STAT3 Serine Phosphorylation by ERK-Dependent and -Independent Pathways Negatively Modulates Its Tyrosine Phosphorylation

1997 • 612 citations

SYSTEMIC THERAPY FOR RENAL CELL CARCINOMA

2000 • 610 citations

Immunohistochemical analysis of bcl-2, bax, bcl-X, and mcl-1 expression in prostate cancers.

1996 • 596 citations

Requirement for MAP Kinase (ERK2) Activity in Interferon α- and Interferon β-Stimulated Gene Expression Through STAT Proteins

1995 • 549 citations

Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor- mediated cell growth In vitro.

1998 • 508 citations

Interleukin‐6 (IL‐6) functions as an in vitro autocrine growth factor in renal cell carcinomas

1989 • 420 citations

IL-6 triggers cell growth via the Ras-dependent mitogen-activated protein kinase cascade.

1997 • 416 citations

Interleukin-6 as a paracrine and autocrine growth factor in human prostatic carcinoma cells in vitro.

1997 • 308 citations

Constitutive activation of mitogen-activated protein (MAP) kinases in human renal cell carcinoma.

1995 • 304 citations

MECHANISMS OF CARDIAC PAIN

1999 • 242 citations

Role of interleukin-6 in the paraneoplastic inflammatory syndrome associated with renal-cell carcinoma

1997 • 241 citations

Rapid inhibition of interleukin-6 signaling and Stat3 activation mediated by mitogen-activated protein kinases

1998 • 227 citations

Constitutive activation of a slowly migrating isoform of Stat3 in mycosis fungoides: Tyrphostin AG490 inhibits Stat3 activation and growth of mycosis fungoides tumor cell lines

1997 • 226 citations

Inhibition of constitutively activated Stat3 signaling pathway suppresses growth of prostate cancer cells.

2000 • 212 citations

Role of reactive oxygen species in cis-dichlorodiammineplatinum-induced cytotoxicity on bladder cancer cells

1997 • 170 citations

JAK2 tyrosine kinase inhibitor tyrphostin AG490 downregulates the mitogen‐activated protein kinase (MAPK) and signal transducer and activator of transcription (STAT) pathways and induces apoptosis in myeloma cells

2000 • 170 citations

JAK3, STAT, and MAPK Signaling Pathways as Novel Molecular Targets for the Tyrphostin AG-490 Regulation of IL-2-Mediated T Cell Response

1999 • 164 citations

An alternative pathway for STAT activation that is mediated by the direct interaction between JAK and STAT

1997 • 158 citations

STAT3 Is a Serine Kinase Target in T Lymphocytes

1997 • 139 citations

STAT3 mediates the survival signal in oncogenicras-transfected intestinal epithelial cells

1998 • 130 citations

Tyrphostin AG-490 inhibits cytokine-mediated JAK3/STAT5a/b signal transduction and cellular proliferation of antigen-activated human T cells

1999 • 110 citations

Growth regulation of human renal carcinoma cells: role of transforming growth factor alpha.

1992 • 108 citations

Interleukin-6-induced STAT3 transactivation and Ser727 phosphorylation involves Vav, Rac-1 and the kinase SEK-1/MKK-4 as signal transduction components

2000 • 101 citations

Epidermal growth factor-induced growth inhibition requires Stat1 activation.

1998 • 100 citations

Constitutive activation of a slowly migrating isoform of Stat3 in mycosis fungoides : tyrphostin AG490 inhibits Stat3 activation and growth of mycosis fungoides tumor cell lines

1997 • 93 citations

Stress activated protein kinase p38 is involved in IL-6 induced transcriptional activation of STAT3

1999 • 89 citations

Frequent expression of Bcl-2 in renal-cell carcinomas carrying wild-type p53

1996 • 71 citations

IMMUNOHISTOCHEMICAL ANALYSIS OF BCL-2 PROTEIN EXPRESSION IN RENAL CELL CARCINOMA

1999 • 48 citations

Interleukin-6 and TNFα production in human renal cell carcinoma

1993 • 44 citations