Phenotypes of T Cells in the Gut

Lymphocyte Homing and Homeostasis

1996 • 2,934 citations

Adhesion between epithelial cells and T lymphocytes mediated by E-cadherin and the αEβ7 integrin

1994 • 1,131 citations

A tissue-specific endothelial cell molecule involved in lymphocyte homing

1988 • 725 citations

Immunobiology and immunopathology of human gut mucosa: Humoral immunity and intraepithelial lymphocytes

1989 • 552 citations

A monoclonal antibody (HML‐1) defining a novel membrane molecule present on human intestinal lymphocytes

1987 • 461 citations

The mouse gut T lymphocyte, a novel type of T cell. Nature, origin, and traffic in mice in normal and graft-versus-host conditions.

1978 • 422 citations

Identification of novel lymphoid tissues in murine intestinal mucosa where clusters of c-kit+ IL-7R+ Thy1+ lympho-hemopoietic progenitors develop.

1996 • 400 citations

Segmented Filamentous Bacteria Are Indigenous Intestinal Bacteria That Activate Intraepithelial Lymphocytes and Induce MHC Class II Molecules and Fucosyl Asialo GM1 Glycolipids on the Small Intestinal Epithelial Cells in the Ex‐Germ‐Free Mouse

1995 • 344 citations

Intestinal lymphocyte subpopulations in inflammatory bowel disease: an analysis by immunohistological and cell isolation techniques.

1984 • 273 citations

Subsets of CD3⁺ (T cell receptor α/β or γ/δ) and CD3⁻ lymphocytes isolated from normal human gut epithelium display phenotypical features different from their counterparts in peripheral blood

1990 • 269 citations

A major fraction of human intraepithelial lymphocytes simultaneously expresses the γ/δ T cell receptor, the CD8 accessory molecule and preferentially uses the V_δ1 gene segment

1991 • 261 citations

Expression of disulfide‐linked and non‐disulfide‐linked forms of the T cell receptor γ/δ heterodimer in human intestinal intraepithelial lymphocytes

1989 • 248 citations

Oligoclonal Expansion and CD1 Recognition by Human Intestinal Intraepithelial Lymphocytes

1991 • 243 citations

Expression and regulation of β₇(βp) integrins on mouse lymphocytes: Relevance to the mucosal immune system

1991 • 222 citations

Number and distribution of lymphocytes in man. A critical analysis

1974 • 217 citations

Increased activation of isolated intestinal lamina propria mononuclear cells in inflammatory bowel disease

1991 • 207 citations

Intra-epithelial lymphocytes. Evidence for regional specialization and extrathymic T cell maturation in the human gut epithelium

1995 • 196 citations

A fundamental subdivision of circulating lymphocytes defined by adhesion to mucosal addressin cell adhesion molecule-1. Comparison with vascular cell adhesion molecule-1 and correlation with beta 7 integrins and memory differentiation.

1996 • 191 citations

Activation of peripheral blood and intestinal lamina propria lymphocytes in Crohn's disease. In vivo state of activation and in vitro response to stimulation as defined by the expression of early activation antigens.

1987 • 182 citations

Lymphocyte subpopulations in the human small intestine. The findings in normal mucosa and in the mucosa of patients with adult coeliac disease.

1983 • 169 citations

Increased concentrations of interleukin 1 beta, interleukin-2, and soluble interleukin-2 receptors in endoscopical mucosal biopsy specimens with active inflammatory bowel disease.

1992 • 169 citations

Oligoclonality of human intestinal intraepithelial T cells.

1992 • 165 citations

T cell differentiation antigens on lymphocytes in the human intestinal lamina propria.

1992 • 165 citations

Lymphocytes isolated from the intestinal lamina propria of normal nonhuman primates have increased expression of genes associated with T-cell activation

1988 • 163 citations

Studies of intestinal lymphoid tissue

1980 • 160 citations

History of Oral Tolerance and Mucosal Immunitya

1996 • 158 citations

Differential expression of CD25 (interleukin-2 receptor) on lamina propria T cells and macrophages in the intestinal lesions in Crohn's disease and ulcerative colitis.

1990 • 158 citations

Intestinal Intraepithelial Lymphocytes

1991 • 152 citations

Extrathymic intestinal T-cell development: virtual reality?

1995 • 149 citations

The HML-1 antigen of intestinal lymphocytes is an activation antigen.

1990 • 141 citations

Human mucosal addressin cell adhesion molecule-1 (MAdCAM-1) demonstrates structural and functional similarities to the alpha 4 beta 7-integrin binding domains of murine MAdCAM-1, but extreme divergence of mucin-like sequences.

1996 • 128 citations

Alpha 4 beta 7 integrin mediates B cell binding to fibronectin and vascular cell adhesion molecule-1. Expression and function of alpha 4 integrins on human B lymphocytes.

1993 • 128 citations

Peripheral monocyte and naive T-cell recruitment and activation in Crohn's disease

1995 • 127 citations

Distribution of macrophages and granulocytes expressing L1 protein (calprotectin) in human Peyer's patches compared with normal ileal lamina propria and mesenteric lymph nodes.

1993 • 123 citations

Heterogeneity of M-cell-associated B and T cells in human Peyer's patches.

1994 • 121 citations

Microbial colonization influences composition and T‐cell receptor Vβ repertoire of intraepithelial lymphocytes in rat intestine

1996 • 119 citations

T cell antigen receptor V gene usage. Increases in V beta 8+ T cells in Crohn's disease.

1990 • 113 citations

Lymphocyte migration into tissue: the paradigm derived from CD4 subsets

1996 • 106 citations

Topographic distribution of homing receptors on B and T cells in human gut-associated lymphoid tissue: relation of L-selectin and integrin alpha 4 beta 7 to naive and memory phenotypes.

1997 • 98 citations

T-cell activation in Crohn's disease. Increased levels of soluble interleukin-2 receptor in serum and in supernatants of stimulated peripheral blood mononuclear cells.

1990 • 98 citations

Collagenous colitis: jejunal and colorectal pathology.

1992 • 96 citations

Evidence that intestinal intraepithelial lymphocytes are activated cytotoxic T cells in celiac disease but not in giardiasis.

1996 • 94 citations

Distribution of β₇ integrins in human intestinal mucosa and organized gut‐associated lymphoid tissue

1996 • 93 citations

Gamma delta T cell receptor-positive cells of the human gastrointestinal mucosa: occurrence and V region gene expression in Heliobacter pylori-associated gastritis, coeliac disease and inflammatory bowel disease.

1991 • 92 citations

T cell subclasses in fetal human ileum.

1986 • 87 citations

Intestinal immune reactivity to interleukin 2 differs among Crohn's disease, ulcerative colitis, and controls

1989 • 84 citations

Expression of the Mucosal Homing Receptor α₄β₇Correlates with the Ability of CD8⁺Memory T Cells To Clear Rotavirus Infection

1998 • 83 citations

Immunopathology of human inflammatory bowel disease

1997 • 82 citations

Lack of relation between expression of HLA-DR and secretory component (SC) in follicle-associated epithelium of human Peyer's patches.

1988 • 80 citations

γδ T cells in the human intestine express surface markers of activation and are preferentially located in the epithelium

1990 • 79 citations

Immunohistochemical characterization, distribution, and ultrastructure of lymphocytes bearing T-cell receptor γ/δ in inflammatory bowel disease

1991 • 79 citations

Regional Specialization of Intraepithelial T Cells in the Murine Small and Large Intestine

1995 • 79 citations

Continuous in vivo activation and transient hyporesponsiveness to TcR/CD3 triggering of human gut lamina propria lymphocytes

1993 • 78 citations

T Lymphocytes in Human Gut Epithelium Preferentially Express the α/β Antigen Receptor and are often CD45/UCHL1‐Positive

1989 • 78 citations

Routes of immunization and antigen delivery systems for optimal mucosal immune responses in humans.

1997 • 73 citations

Developmental relationship between cytotoxic α/β T cell receptor‐positive intraepithelial lymphocytes and Peyer's patch lymphocytes

1993 • 72 citations

Plasma and tissue interleukin-2 receptor levels in inflammatory bowel disease

1990 • 70 citations

Phenotypes of B and T cells in human intestinal and mesenteric lymph

1997 • 66 citations

Human CD8⁺ intraepithelial T lymphocytes are mainly CD45RA⁻RB⁺ and show increased co‐expression of CD45R0 in celiac disease

1990 • 66 citations

The role of activated T lymphocytes in gastrointestinal disease

1990 • 64 citations

Selective expansion of specific T cell receptors in the inflamed colon of Crohn's disease.

1996 • 61 citations

Aetiology and pathogenesis of chronic inflammatory bowel disease

1994 • 55 citations

The life and times of an intestinal M cell

1996 • 48 citations

Density of γ/δ+ T cells in the jejunal epithelium of patients with coeliac disease and dermatitis herpetiformis is increased with age

1997 • 46 citations

Intraepithelial gamma/delta T cells in duodenal mucosa are related to the immune state and survival time in AIDS

1996 • 44 citations

Lymphocyte homing: The scent of a follicle

1997 • 43 citations

Mucosal aspects of primary B-cell deficiency and gastrointestinal infections

1995 • 37 citations

An electron microscopic study of intraepithelial lymphocytes in human fetal small intestine.

1977 • 36 citations

T lymphocyte subpopulations and immunoglobulin-containing cells in the colonic mucosa of ulcerative colitis; a morphometric and immunohistochemical study.

1988 • 36 citations

Correlation of extracellular matrix components with the cytoarchitecture of mouse Peyer's patches

1992 • 33 citations

Increased in vitro release of soluble interleukin 2 receptor by colonic lamina propria mononuclear cells in inflammatory bowel disease.

1992 • 30 citations

Lamina propria lymphocytes are derived from circulating cells that lack the Leu-8 lymph node homing receptor

1991 • 30 citations

Intraepithelial Lymphocytes and Their Recognition of Non-Classical MHC Molecules

1994 • 28 citations

TCR expression in human fetal intestine and identification of an early T cell receptor beta-chain transcript.

1997 • 27 citations

Demonstration of local clonality of mucosal T cells in human colon using DNA obtained by microdissection of immunohistochemically stained tissue sections

1996 • 26 citations

Development of the mucosal immune system in humans

1996 • 25 citations

Immunopathology of gluten-sensitive enteropathy

1997 • 25 citations

Selective induction of peripheral and mucosal endothelial cell addressins with peripheral lymph nodes and Peyer's patch cell-conditioned media

1996 • 23 citations

The immunopathology of M cells

1997 • 21 citations

Immunohistochemical findings in jejunal specimens from patients with IgA deficiency.

1995 • 20 citations

Increased HLA-DR and decreased CD3 on human intestinal intraepithelial lymphocytes: evidence of activation?

1996 • 19 citations

Intraepithelial lymphocyte mitosis in a jejunal biopsy correlates with intraepithelial lymphocyte count, irrespective of diagnosis.

1986 • 19 citations

Selective loss of S-phase cells when making cell suspensions from lymphoid tissue

1979 • 19 citations

Distribution and Phenotypes of Duodenal Intraepithelial γ/δ T Cells in Patients with Various Types of Primary B-Cell Deficiency

1993 • 18 citations

Gut intraepithelial lymphocyte counts in neonates, infants and children

1994 • 17 citations

An alternative approach to the assessment of γδ T-cell clonality in celiac disease intestinal lesions through cDNA heteroduplex analysis of T-cell receptor VJ junctions

1994 • 17 citations

Intraepithelial and lamina propria leucocyte subsets in inflammatory bowel disease: an immunohistochemical study of colon and rectal biopsy specimens.

1995 • 17 citations

Immunopathology of human immunodeficiency virus infection in the gastrointestinal tract

1997 • 15 citations

Evidence against T‐cell development in the adult human intestinal mucosa based upon lack of terminal deoxynucleotidyltransferase expression

1996 • 14 citations

Flow cytometric analysis of intraepithelial lymphocytes from human small intestinal biopsies reveals populations of CD4+CD8+ and CD8αα+ cells

1993 • 13 citations

T cell receptor V beta expression in human intestine: regional variation in postnatal intestine and biased usage in fetal gut.

1996 • 12 citations

Immunology of inflammatory bowel disease

1992 • 7 citations

Transient IgA and IgM deficiencies are frequent in children with ulcerative colitis

1988 • 6 citations

Analysis of Germline and Expressed T Cell Receptor Variable Region Genes in Crohn's Disease

1996 • 1 citations