Mechanism of inhibition of trypanothione reductase and glutathione reductase by trivalent organic arsenicals

The protein data bank: A computer-based archival file for macromolecular structures

1977 • 8,627 citations

Esters of Methanesulfonic Acid as Irreversible Inhibitors of Acetylcholinesterase

1962 • 1,510 citations

A simple colorimetric method for the measurement of hydrogen peroxide produced by cells in culture

1980 • 1,180 citations

METABOLISM AND FUNCTIONS OF TRYPANOTHIONE IN THE KINETOPLASTIDA

1992 • 736 citations

Trypanothione: A Novel Bis(glutathionyl)spermidine Cofactor for Glutathione Reductase in Trypanosomatids

1985 • 668 citations

Refined structure of glutathione reductase at 1.54 Å resolution

1987 • 498 citations

Arsenical-resistant trypanosomes lack an unusual adenosine transporter

1993 • 357 citations

Substrate binding and catalysis by glutathione reductase as derived from refined enzyme: Substrate crystal structures at 2Å resolution

1989 • 309 citations

Chemistry and Biochemistry of Flavoenzymes

2019 • 297 citations

Purification and characterization of trypanothione reductase from Crithidia fasciculata, a new member of the family of disulfide-containing flavoprotein reductases

1986 • 267 citations

Human Glutathione Reductase: Purification of the Crystalline Enzyme from Erythorocytes

1974 • 215 citations

Trypanothione is the primary target for arsenical drugs against African trypanosomes.

1989 • 196 citations

In vivo effects of difluoromethylornithine on trypanothione and polyamine levels in bloodstream forms of Trypanosoma brucei

1987 • 175 citations

Efficacy and toxicity of eflornithine for treatment of Trypanosoma brucei gambiense sleeping sickness

1992 • 132 citations

Novel biochemical pathways in parasitic protozoa

1989 • 125 citations

Carbohydrate Metabolism in African Trypanosomes, with Special Reference to the Glycosome

1986 • 122 citations

Mel B in the Treatment of Human Trypanosomiasis

1949 • 121 citations

Active site of trypanothione reductase

1992 • 113 citations

Substrate interactions between trypanothione reductase and N¹‐glutathionylspermidine disulphide at 0.28‐nm resolution

1993 • 111 citations

Characterisation of melarsen-resistant Trypanosoma brucei brucei with respect to cross-resistance to other drugs and trypanothione metabolism

1992 • 96 citations

Levels of Polyamines, Glutathione and Glutathione-Spermidine Conjugates during Growth of the Insect Trypanosomatid Crithidia fasciculata

1988 • 96 citations

X-ray structure of trypanothione reductase from Crithidia fasciculata at 2.4-A resolution.

1991 • 88 citations

Clinical Aspects of Inhibition of Ornithine Decarboxylase with Emphasis on Therapeutic Trials of Eflornithine (DFMO) in Cancer and Protozoan Diseases

1987 • 83 citations

Acetylcholinesterase. Two types of inhibition by an organophosphorus compound: one the formation of phosphorylated enzyme and the other analogous to inhibition by substrate

1969 • 79 citations

Differential susceptibility to DL-alpha-difluoromethylornithine in clinical isolates of Trypanosoma brucei rhodesiense

1990 • 75 citations

Dihydrolipoamide dehydrogenase from Trypanosoma brucei. Characterization and cellular location

1987 • 72 citations

Effects of various metabolic conditions and of the trivalent arsenical melarsen oxide on the intracellular levels of fructose 2,6‐bisphosphate and of glycolytic intermediates in Trypanosoma brucei

1987 • 61 citations

Expression of Trypanosoma congolense trypanothione reductase in Escherichia coli: overproduction, purification, and characterization

1989 • 54 citations

Sulfhydryl Agents: Arsenicals

1963 • 41 citations

Treatment of arsenical refractory Rhodesian sleeping sickness in Kenya

1989 • 37 citations

The interaction of arsenical drugs with dihydrolipoamide and dihydrolipoamide dehydrogenase from arsenical resistant and sensitive strains of Trypanosoma brucei brucei

1992 • 36 citations

Differential sensitivity of Trypanosoma brucei rhodesiense isolates to in Vitro lysis by arsenicals

1991 • 33 citations

The action of trypanocidal arsenical drugs on Trypanosoma brucei and Trypanosoma rhodesiense

1974 • 25 citations

Therapy for African trypanosomiasis

1991 • 13 citations

Synthesis of substrate analogues for trypanothione reductase

1993 • 12 citations

The Endogenous Development of the Coccidia of the Ferret, and the Histopathological Reaction of the Infected Intestinal Villi

1935 • 12 citations