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1987 • 2,704 citations

Enduring changes in brain and behavior produced by chronic amphetamine administration: A review and evaluation of animal models of amphetamine psychosis

1986 • 2,110 citations

Cellular and Molecular Mechanisms of Drug Dependence

1988 • 2,094 citations

Brain Dopamine and Reward

1989 • 1,899 citations

Enduring changes in brain and behavior produced by chronic amphetamine administration: A review and evaluation of animal models of amphetamine psychosis

1986 • 1,751 citations

Molecular mechanisms of drug addiction

2004 • 1,080 citations

Cocaine and Other Stimulants

1988 • 982 citations

Autoradiographic differentiation of mu, delta and kappa opioid receptors in the rat forebrain and midbrain

1988 • 980 citations

Opposite effects of mu and kappa opiate agonists on dopamine release in the nucleus accumbens and in the dorsal caudate of freely moving rats.

1988 • 913 citations

Extinction and recovery of cocaine self-administration following 6-hydroxydopamine lesions of the nucleus accumbens

1980 • 736 citations

Selective 60HDA-induced destruction of mesolimbic dopamine neurons: Abolition of psychostimulant-induced locomotor activity in rats

1976 • 706 citations

Heroin and cocaine intravenous self-administration in rats: Mediation by separate neural systems

1982 • 560 citations

The immunocytochemical localization of enkephalin in the central nervous system of the rat

1981 • 553 citations

The Effects of Opioid Peptides on Dopamine Release in the Nucleus Accumbens: An In Vivo Microdialysis Study

1990 • 539 citations

Effect of acute and daily cocaine treatment on extracellular dopamine in the nucleus accumbens

1990 • 538 citations

Blockade of cocaine reinforcement in rats with the dopamine receptor blocker pimozide, but not with the noradrenergic blockers phentolamine or phenoxybenzamine.

1977 • 490 citations

Drug reinforcement studied by the use of place conditioning in rat

1982 • 482 citations

The neuropharmacological basis of reward

1991 • 457 citations

Conditioned place preference as a measure of drug reward.

1989 • 456 citations

Persistent sensitization of dopamine neurotransmission in ventral striatum (nucleus accumbens) produced by prior experience with (+)-amphetamine: a microdialysis study in freely moving rats

1988 • 455 citations

Increasing effects of repetitive cocaine administration in the rat

1976 • 437 citations

Cocaine and Other Stimulants

1977 • 421 citations

Behavioral effects of separate and combined administration of naloxone and d-amphetamine.

1974 • 411 citations

Molecular mechanisms of drug addiction [published erratum appears in J Neurosci 1992 Aug;12(8):following table of contents]

1992 • 392 citations

Dopaminergic substrates of amphetamine-induced place preference conditioning

1982 • 381 citations

Repeated cocaine administration causes persistent enhancement of D1 dopamine receptor sensitivity within the rat nucleus accumbens.

1991 • 359 citations

Climbing behavior induced by apomorphine in mice: a simple test for the study of dopamine receptors in striatum

1976 • 341 citations

Behavioral and neurochemical effects of acute and daily cocaine administration in rats.

1988 • 299 citations

Microinjection of cocaine into the nucleus accumbens elicits locomotor activation in the rat

1990 • 274 citations

The neuropharmacological basis of reward

1991 • 249 citations

Repeated cocaine administration upregulates K and μ, but not δ, opioid receptors

1994 • 230 citations

THE EFFECT OF REPEATED DOSES OF COCAINE IN THE RAT

1932 • 217 citations

Opioid Peptide Processing and Receptor Selectivity

1986 • 189 citations

Climbing behaviour induced by apomorphine in mice: A potential model for the detection of neuroleptic activity

1978 • 181 citations

Reinforcing properties of cocaine in the medial prefrontal cortex: Primary action on presynaptic dopaminergic terminals

1986 • 169 citations

Cocaine: Discussion on the Role of Dopamine in the Biochemical Mechanism of Action

1977 • 165 citations

Opiate antagonists reduce cocaine but not nicotine self-administration

1991 • 161 citations

Influence of a single injection of cocaine, amphetamine or GBR 12909 on mRNA expression of striatal neuropeptides

1992 • 159 citations

Effect of ?-Endorphin and naloxone on acquisition, memory, and retrieval of shuttle avoidance and habituation learning in rats

1980 • 143 citations

L-name and MK-801 attenuate sensitization to the locomotor-stimulating effect of cocaine

1993 • 133 citations

Effects of d-amphetamine and naloxone on brain stimulation reward

1980 • 122 citations

Cocaine place preference is blocked by the δ-opioid receptor antagonist, naltrindole

1992 • 109 citations

Cocaine alters opiate receptor binding in critical brain reward regions

1989 • 109 citations

Naloxone attenuation of the effect of cocaine on rewarding brain stimulation

1987 • 107 citations

Opioid mediation of cocaine-induced hyperactivity and reinforcement

1989 • 104 citations

Intravenous self-administration of cocaine and norcocaine by dogs

1980 • 100 citations

Dual ultrastructural localization of enkephalin and tyrosine hydroxylase immunoreactivity in the rat ventral tegmental area: multiple substrates for opiate-dopamine interactions

1992 • 100 citations

The potentiation of responses to adrenergic nerve stimulation in the presence of cocaine: its relationship to the metabolic fate of released norepinephrine.

1974 • 96 citations

Inhibition by MK-801 of cocaine-induced sensitization, conditioned place preference, and dopamine-receptor supersensitivity in mice

1996 • 85 citations

Cyclo (leucylglcine) inhibits the development of morphine induced analgesic tolerance and dopamine receptor supersensitivity in rats

1980 • 84 citations

Acute effects of cocaine on spontaneous and discriminative motor functions: relation to route of administration and pharmacokinetics.

1991 • 79 citations

EFFECTS OF ACUTE COCAINE TREATMENT ON THE TURNOVER OF 5‐HYDROXYTRYPTAMINE IN THE RAT BRAIN

1975 • 73 citations

Behavioural and neurochemical effects of repeated administration of cocaine in rats

1978 • 71 citations

Rotational behavior induced by cocaine analogs in rats with unilateral 6-hydroxydopamine lesions of the substantia nigra: dependence upon dopamine uptake inhibition.

1979 • 68 citations

Cocaine-induced supersensitivity of striatal dopamine receptors: role of endogenous calmodulin

1981 • 68 citations

Nitric oxide mediation of cocaine-induced dopaminergic behaviors: ambulation-accelerating activity, reverse tolerance and conditioned place preference in mice.

1995 • 66 citations

Naloxone reduces amphetamine-induced stimulation of locomotor activity and in vivo dopamine release in the striatum and nucleus accumbens

1992 • 61 citations

Strategies for studying the neurochemical substrates of drug reinforcement in rodents

1983 • 61 citations

Physiological disposition and biotransformation of [allyl-1', 3' - 14C naloxone in the rat and some comparative observations on nalorphine.

1976 • 58 citations

The δ-opioid receptor antagonist naltrindole prevents sensitization to the conditioned rewarding effects of cocaine

1995 • 58 citations

Blockade of cocaine-induced conditioned place preference: Relevance to cocaine abuse therapeutics

1995 • 57 citations

Cocaine self-administration and naltrindole, a delta-selective opioid antagonist

1995 • 56 citations

Behavioral and biochemical evidence of opioidergic involvement in cocaine sensitization.

1995 • 50 citations

Effects of naloxone on d-amphetamine- and apomorphine-induced behavior

1982 • 46 citations

Apomorphine-induced stereotypic cage climbing in mice as a model for studying changes in dopamine receptor sensitivity

1980 • 42 citations

Interaction between opioid antagonists and amphetamine: evidence for mediation by central delta opioid receptors.

1992 • 42 citations

The role of dopaminergic mechanisms in naloxone-induced inhibition of apomorphine-induced stereotyped behavior

1980 • 40 citations

Influence of naloxone upon motor activity induced by psychomotor stimulant drugs

1994 • 36 citations

Potentiation of apomorphine and d-amphetamine effects by naloxone

1981 • 35 citations

Dose-dependent conditioned place preference produced by etonitazene and morphine

1992 • 34 citations

Neuropharmacology of Cocaine: Role of Monoaminergic Systems

2015 • 34 citations

Naltrindole, an opioid delta receptor antagonist, blocks cocaine-induced facilitation of responding for rewarding brain stimulation

1993 • 34 citations

Inhibition of cocaine-induced sensitization by the δ-opioid receptor antagonist naltrindole

1993 • 34 citations

Interactions of naloxone with morphine, amphetamine and phencyclidine on fixed interval responding for intracranial self-stimulation in rats

1990 • 33 citations

Technique for the continuous infusion of high doses of cocaine by osmotic minipump

1993 • 30 citations

Cocaine facilitation of prefrontal cortex self-stimulation: a microstructural and pharmacological analysis

1992 • 28 citations

Acute effects of D-1 and D-2 dopamine receptor agonist and antagonist drugs on basal ganglia [Met5]- and [Leu5]-enkephalin and neurotensin content in the rat

1991 • 25 citations

The proenkephalin a fragment, peptide E: Central processing and CNS activity in vivo

1985 • 22 citations

Potentiation of apomorphine-induced stereotypies by naloxone and L-prolyl-L-leucyl-glycinamide

1983 • 19 citations

Technical report: The subcutaneous administration of cocaine in the rat

1994 • 19 citations

Effect of naloxone and morphine on dopamine agonist-induced stereotypy in rats and guinea pigs

1983 • 12 citations

Effects of naloxone infusion upon spontaneous and amphetamine-induced activity

1992 • 11 citations