The place of lithium salts in psychiatric practice 50 years on
Data up to Jan 2025
Total Citations Per Year
Abstract
References (79)
Neurogenesis in the adult human hippocampus
1998 • 6,181 citations
Subgenual prefrontal cortex abnormalities in mood disorders
1997 • 2,646 citations
A molecular mechanism for the effect of lithium on development.
1996 • 2,270 citations
Morphometric evidence for neuronal and glial prefrontal cell pathology in major depression∗∗See accompanying Editorial, in this issue.
1999 • 1,450 citations
LITHIUM SALTS IN THE TREATMENT OF PSYCHOTIC EXCITEMENT
1949 • 1,401 citations
Neurogenesis in the Neocortex of Adult Primates
1999 • 1,268 citations
Neural and developmental actions of lithium: A unifying hypothesis
1989 • 1,005 citations
A Randomized, Placebo-Controlled 12-Month Trial of Divalproex and Lithium in Treatment of Outpatients With Bipolar I Disorder
2000 • 683 citations
Enhancement of Hippocampal Neurogenesis by Lithium
2000 • 613 citations
Lifetime risk of suicide for affective disorder, alcoholism and schizophrenia
1998 • 582 citations
Drug Therapy in the Prevention of Recurrences in Unipolar and Bipolar Affective Disorders
1984 • 569 citations
Efficacy of Olanzapine in Acute Bipolar Mania<subtitle>A Double-blind, Placebo-Controlled Study</subtitle>
2000 • 557 citations
Lithium activates the serine/threonine kinase Akt-1 and suppresses glutamate-induced inhibition of Akt-1 activity in neurons
1999 • 537 citations
The Mood‐Stabilizing Agents Lithium and Valproate RobustlIncrease the Levels of the Neuroprotective Protein bcl‐2 in the CNS
1999 • 495 citations
Risk of Recurrence of Bipolar Disorder in Pregnant and Nonpregnant Women After Discontinuing Lithium Maintenance
2000 • 482 citations
Long Term Lithium Treatment Suppresses p53 and Bax Expression but Increases Bcl-2 Expression
1999 • 470 citations
A reduction of nonpyramidal cells in sector CA2 of schizophrenics and manic depressives
1998 • 468 citations
Bcl-2 promotes regeneration of severed axons in mammalian CNS
1997 • 449 citations
The Mood‐Stabilizing Agent Valproate Inhibits the Activity of Glycogen Synthase Kinase‐3
2000 • 434 citations
Evidence-based guidelines for treating depressive disorders with antidepressants: a revision of the 1993 British Association for Psychopharmacology guidelines
2000 • 422 citations
Lithium increases N-acetyl-aspartate in the human brain: in vivo evidence in support of bcl-2’s neurotrophic effects?
2000 • 398 citations
THE BIOLOGY OF IMPULSIVITY AND SUICIDALITY
2000 • 314 citations
Lithium at 50: have the neuroprotective effects of this unique cation been overlooked?
1999 • 312 citations
Glycogen Synthase Kinase-3β Facilitates Staurosporine- and Heat Shock-induced Apoptosis
2000 • 305 citations
Lithium Augmentation in Treatment-Resistant Depression: Meta-Analysis of Placebo-Controlled Studies
1999 • 304 citations
Suicidal behavior in bipolar mood disorder: clinical characteristics of attempters and nonattempters
2000 • 294 citations
Prophylactic Efficacy of Lithium Carbonate in Manic-Depressive Illness
1973 • 283 citations
Importance of Psychiatric Diagnosis in Prediction of Clinical Drug Effects
1967 • 273 citations
Neuroprotective effects of chronic lithium on focal cerebral ischemia in rats
1998 • 256 citations
Protein kinase C signaling in the brain: molecular transduction of mood stabilization in the treatment of manic-depressive illness
1999 • 247 citations
Risperidone compared with both lithium and haloperidol in mania: a double-blind randomized controlled trial.
1998 • 244 citations
Association of polymorphism of serotonin 2A receptor gene with suicidal ideation in major depressive disorder
2000 • 229 citations
Lithium Carbonate and Imipramine in the Prophylaxis of Unipolar and Bipolar II Illness
1982 • 213 citations
Signaling: cellular insights into the pathophysiology of bipolar disorder
2000 • 212 citations
Double-Blind Comparison of Addition of a Second Mood Stabilizer Versus an Antidepressant to an Initial Mood Stabilizer for Treatment of Patients With Bipolar Depression
2000 • 209 citations
Substance P and the Neurokinins: Novel Peptide Neurotransmitters in Psychopharmacology
1999 • 208 citations
Temporal Dissociation Between Lithium-Induced Changes in Frontal Lobe myo-Inositol and Clinical Response in Manic-Depressive Illness
1999 • 191 citations
Olanzapine compared to lithium in mania: a double-blind randomized controlled trial
1999 • 170 citations
Double-Blind, Placebo-Controlled Trial of the Use of Lithium to Augment Antidepressant Medication in Continuation Treatment of Unipolar Major Depression
2000 • 168 citations
The role of p53 in neuronal cell death
2000 • 167 citations
Lithium therapy and signal transduction
2000 • 155 citations
Bipolar depression: pharmacotherapy and related therapeutic strategies
2000 • 154 citations
Overview of the mechanism of action of lithium in the brain: fifty-year update.
2000 • 153 citations
MRI-based measurements of temporal lobe and ventricular structures in patients with bipolar I and bipolar II disorders
2000 • 145 citations
Continuation therapy with lithium and amitriptyline in unipolar depressive illness: a randomized, double-blind, controlled trial
1984 • 139 citations
Lithium Prophylaxis in Recurrent Affective Illness
1994 • 135 citations
Clozapine in the Treatment of Refractory Psychotic Mania
2000 • 133 citations
Mood stabilizers in the prevention of recurrent affective disorders: a meta‐analysis
1999 • 123 citations
Lamotrigine compared with lithium in mania: a double-blind randomized controlled trial.
2000 • 108 citations
Paroxetine in the Treatment of Primary Insomnia
1999 • 99 citations
Lamotrigine Compared with Lithium in Mania: A Double-Blind Randomized Controlled Trial
2000 • 88 citations
Mortality in 497 Patients with Affective Disorders Attending a Lithium Clinic or after Having Left it
2000 • 88 citations
The new generation of antipsychotic drugs: how atypical are they?
2000 • 87 citations
The current status of the platelet 5-HT2A receptor in depression
2000 • 86 citations
Outcome in the Pharmacologic Treatment of Bipolar Disorder
1996 • 83 citations
The Use of Quetiapine for Treatment-Resistant Bipolar Disorder: A Case Series
1999 • 78 citations
The comparative prophylactic efficacy of lithium and carbamazepine in patients with bipolar I disorder
1999 • 65 citations
Outcome of lithium prophylaxis: a prospective follow‐up of affective disorder patients assigned to high and low serum lithium levels
1998 • 62 citations
The comparative prophylactic efficacy of lithium and carbamazepine in patients with bipolar I disorder
1999 • 60 citations
I Know This Much Is True
2000 • 56 citations
Concurrent measures of protein kinase C and phosphoinositides in lithium-treated bipolar patients and healthy individuals: a preliminary study
2000 • 48 citations
Lithium attenuates p53 levels in human neuroblastoma SH-SY5Y cells
1999 • 46 citations
Lithium therapy and suicide risk.
1999 • 45 citations
Lithium and recurrence in a long-term follow-up of bipolar affective disorder
1997 • 43 citations
Neuroleptics in Acute Mania: A Pharmacoepidemiologic Study
1996 • 42 citations
Effects of acute tryptophan depletion on mood and suicidal ideation in bipolar patients symptomatically stable on lithium
2000 • 40 citations
Lithium in the Prophylactic Treatment of Affective Disorders
1979 • 39 citations
Treatment of manic episodes in Scandinavia: the use of neuroleptic drugs in a clinical routine setting
1994 • 38 citations
Acta Neuropsychiatrica 4.0
2011 • 37 citations
The impact of the discovery of lithium on psychiatric thought and practice in the USA and Europe
1999 • 30 citations
The prophylactic efficacy of lithium - transient or persistent?
1999 • 25 citations
Cluster analysis of clinical data to identify subtypes within a study population following treatment with a new pentapeptide antidepressant
2000 • 15 citations
Role of serotonergic 5-HT2A receptors in the psychotomimetic actions of phencyclidine
2000 • 12 citations
Effect of Lithium Carbonate on the Enhancement of Serotonin 2A Receptor Elicited by Dexamethasone
2000 • 12 citations
Typical and atypical antipsychotics in bipolar disorder
2000 • 9 citations
Lithium Perspectives
1983 • 7 citations
The efficacy of valproate, lamotrigine and gabapentin in bipolar disorder; review of double-blind controlled studies
2000 • 6 citations
Lithium and carbamazepine in bipolar disorder
2000 • 5 citations
[Lithium carbonate in Huntington's disease].
1978 • 1 citations