Minocycline blocks 6-hydroxydopamine-induced neurotoxicity and free radical production in rat cerebellar granule neurons

Blockade of Microglial Activation Is Neuroprotective in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Mouse Model of Parkinson Disease

2002 • 1,171 citations

Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice

2002 • 1,071 citations

Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease

2000 • 1,040 citations

A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window

1999 • 1,027 citations

Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia

1998 • 974 citations

Minocycline, a Tetracycline Derivative, Is Neuroprotective against Excitotoxicity by Inhibiting Activation and Proliferation of Microglia

2001 • 919 citations

Minocycline prevents nigrostriatal dopaminergic neurodegeneration in the MPTP model of Parkinson's disease

2001 • 775 citations

Epidermal immunization by a needle-free powder delivery technology: Immunogenicity of influenza vaccine and protection in mice

2000 • 550 citations

Sensitive assay of hydroxyl free radical formation utilizing high pressure liquid chromatography with electrochemical detection of phenol and salicylate hydroxylation products

1984 • 394 citations

Minocycline inhibits microglial activation and protects nigral cells after 6-hydroxydopamine injection into mouse striatum

2001 • 345 citations

Free Radical‐Generated Neurotoxicity of 6‐Hydroxydopamine

1995 • 202 citations

Effect of Antibiotics on the Generation of Reactive Oxygen Species

1986 • 191 citations

Nature of Inhibition of Mitochondrial Respiratory Complex I by 6‐Hydroxydopamine

1996 • 171 citations

Effects of intraventricular 6-hydroxydopamine on the dopaminergic innervation of striatum: Histochemical and neurochemical analysis

1986 • 131 citations

Iron-Mediated Generation of the Neurotoxin 6-Hydroxydopamine Quinone by Reaction of Fatty Acid Hydroperoxides with Dopamine: A Possible Contributory Mechanism for Neuronal Degeneration in Parkinson's Disease

1997 • 127 citations

Caspase-3-like proteases and 6-hydroxydopamine induced neuronal cell death

1999 • 114 citations

Participation of active oxygen species in 6-hydroxydopamine toxicity to a human neuroblastoma cell line

1982 • 98 citations

Generation of the Neurotoxin 6-Hydroxydopamine by Peroxidase/H2O2 Oxidation of Dopamine

1995 • 94 citations

Attenuation of 6‐OHDA‐induced neurotoxicity in glutathione peroxidase transgenic mice

1998 • 87 citations

A Chemically Modified Nonantimicrobial Tetracycline (CMT‐8) Inhibits Gingival Matrix Metalloproteinases, Periodontal Breakdown, and Extra‐Oral Bone Loss in Ovariectomized Rats

1999 • 78 citations

The dopamine agonist pramipexole scavenges hydroxyl free radicals induced by striatal application of 6-hydroxydopamine in rats: an in vivo microdialysis study

2000 • 49 citations

How do Tetracyclines Work?

1998 • 49 citations

Acute effects of 6-hydroxydopa on central monoaminergic neurons

1973 • 48 citations

Effect of iron and manganese on hydroxyl radical production by 6-hydroxydopamine: mediation of antioxidants

2001 • 36 citations

Loss of Striatal DA Innervation Increases Striatal Trophic Activity Directed at DA Neurons in Culture

1996 • 33 citations

6-Hydroxydopamine treatment enhances excitation of cultured cerebellar neurons by glutamate

1986 • 3 citations