The brain mineralocorticoid receptor: greedy for ligand, mysterious in function

Two Receptor Systems for Corticosterone in Rat Brain: Microdistribution and Differential Occupation

1985 • 2,530 citations

Brain Corticosteroid Receptor Balance in Health and Disease*

1998 • 2,442 citations

Cloning of Human Mineralocorticoid Receptor Complementary DNA: Structural and Functional Kinship with the Glucocorticoid Receptor

1987 • 1,920 citations

Primary structure and expression of a functional human glucocorticoid receptor cDNA

1985 • 1,851 citations

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites.

1989 • 1,744 citations

The Role of the Hippocampus in Feedback Regulation of the Hypothalamic-Pituitary-Adrenocortical Axis*

1991 • 1,690 citations

Mineralocorticoid Action: Target Tissue Specificity Is Enzyme, Not Receptor, Mediated

1988 • 1,607 citations

Elevated Concentrations of CSF Corticotropin-Releasing Factor-Like Immunoreactivity in Depressed Patients

1984 • 1,490 citations

Corticosteroid Inhibition of ACTH Secretion*

1984 • 1,212 citations

Brain Corticosteroid Receptor Balance in Health and Disease

1998 • 1,138 citations

Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

1995 • 1,109 citations

LOCALISATION OF 11β-HYDROXYSTEROID DEHYDROGENASE—TISSUE SPECIFIC PROTECTOR OF THE MINERALOCORTICOID RECEPTOR

1988 • 1,047 citations

Hypothalamic Control of Adrenocorticotropin Secretion: Advances since the Discovery of 41-Residue Corticotropin-Releasing Factor

1986 • 874 citations

Brain corticosteroid receptor balance and homeostatic control

1991 • 858 citations

Antidepressants and Hypothalamic-Pituitary-Adrenocortical Regulation

1996 • 829 citations

The Serum Transport of Steroid Hormones

1982 • 777 citations

Selective Retention of Corticosterone by Limbic Structures in Rat Brain

1968 • 700 citations

Effects of the high-affinity corticotropin-releasing hormone receptor 1 antagonist R121919 in major depression: the first 20 patients treated

2000 • 698 citations

Regulation of Serotonin1A, Glucocorticoid, and Mineralocorticoid Receptor in Rat and Human Hippocampus: Implications for the Neurobiology of Depression

1998 • 694 citations

Human P-glycoprotein transports cortisol, aldosterone, and dexamethasone, but not progesterone.

1992 • 677 citations

Regulation of ACTH Secretion: Variations on a Theme of B

1987 • 668 citations

Increased Numbers of Corticotropin-Releasing Hormone Expressing Neurons in the Hypothalamic Paraventricular Nucleus of Depressed Patients

1994 • 657 citations

The rationale for corticotropin-releasing hormone receptor (CRH-R) antagonists to treat depression and anxiety

1999 • 656 citations

Feedback action and tonic influence of corticosteroids on brain function: A concept arising from the heterogeneity of brain receptor systems

1987 • 597 citations

Selective Loss of Hippocampal Granule Cells in the Mature Rat Brain After Adrenalectomy

1989 • 520 citations

Renal mineralocorticoid receptors and hippocampal corticosterone-binding species have identical intrinsic steroid specificity.

1983 • 515 citations

On the Role of Brain Mineralocorticoid (Type I) and Glucocorticoid (Type II) Receptors in Neuroendocrine Regulation

1989 • 473 citations

Evidence for hippocampal regulation of neuroendocrine neurons of the hypothalamo-pituitary-adrenocortical axis

1989 • 459 citations

Differences in Corticosterone and Dexamethasone Binding to Rat Brain and Pituitary¹

1975 • 456 citations

Control of neuronal excitability by corticosteroid hormones

1992 • 399 citations

Corticotropin-releasing hormone mRNA levels in the paraventricular nucleus of patients with Alzheimer's disease and depression

1995 • 398 citations

Effects of Glucocorticoids and Norepinephrine on the Excitability in the Hippocampus

1989 • 383 citations

Relative occupation of type-I and type-II corticosteroid receptors in rat brain following stress and dexamethasone treatment: functional implications

1987 • 375 citations

Altered Hypothalamic-Pituitary-Adrenocortical Regulation in Healthy Subjects at High Familial Risk for Affective Disorders

1995 • 374 citations

Partial colocalization of glucocorticoid and mineralocorticoid receptors in discrete compartments in nuclei of rat hippocampus neurons

1996 • 356 citations

Penetration of Dexamethasone into Brain Glucocorticoid Targets Is Enhanced in mdr1A P-Glycoprotein Knockout Mice*

1998 • 355 citations

Long-term antidepressant administration alters corticotropin-releasing hormone, tyrosine hydroxylase, and mineralocorticoid receptor gene expression in rat brain. Therapeutic implications.

1991 • 338 citations

Chronic treatment of rats with the antidepressant amitriptyline attenuates the activity of the hypothalamic-pituitary-adrenocortical system.

1993 • 335 citations

Localization and Regulation of Glucocorticoid and Mineralocorticoid Receptor Messenger RNAs in the Hippocampal Formation of the Rat

1989 • 319 citations

Anatomical resolution of two types of corticosterone receptor sites in rat brain with in vitro autoradiography and computerized image analysis

1986 • 319 citations

Molecular Properties of Corticosteroid Binding Globulin and the Sex-Steroid Binding Proteins*

1990 • 312 citations

Distribution of the mineralocorticoid and the glucocorticoid receptor mRNAs in the rat hippocampus

1988 • 310 citations

Rat Brain Binds Adrenal Steroid Hormone: Radioautography of Hippocampus with Corticosterone

1972 • 309 citations

Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4-phosphonobutyrate in the cat spinal cord

1982 • 302 citations

Pharmacological and functional characterization of human mineralocorticoid and glucocorticoid receptor ligands

1993 • 299 citations

Heterodimerization between mineralocorticoid and glucocorticoid receptor: A new principle of glucocorticoid action in the CNS

1994 • 285 citations

Subtle shifts in the ratio between pro‐ and antiapoptotic molecules after activation of corticosteroid receptors decide neuronal fate

2000 • 275 citations

Antidepressants Increase Glucocorticoid and Mineralocorticoid Receptor mRNA Expression in Rat Hippocampus in vivo

1992 • 255 citations

Adrenal steroid type I and type II receptor binding: estimates of in vivo receptor number, occupancy, and activation with varying level of steroid

1990 • 238 citations

Effect of bacterial endotoxin and interleukin-1 beta on hippocampal serotonergic neurotransmission, behavioral activity, and free corticosterone levels: an in vivo microdialysis study

1995 • 236 citations

Prediction of Medium-Term Outcome by Cortisol Response to the Combined Dexamethasone-CRH Test in Patients With Remitted Depression

1999 • 234 citations

The Roles of Plasma Binding and Receptor Specificity in the Mineralocorticoid Action of Aldosterone1

1973 • 232 citations

Glucocorticoid and Mineralocorticoid Receptor mRNA Expression in Rat Brain

1989 • 214 citations

Specificity of the Adrenal Steroid Receptor System in Rat Hippocampus*

1982 • 213 citations

Hormonal Response Pattern in the Combined DEX-CRH Test Is Stable over Time in Subjects at High Familial Risk for Affective Disorders

1998 • 210 citations

Corticosteroid Receptor Function Is Decreased in Depressed Patients

1997 • 204 citations

Corticosterone and Serotonergic Neurotransmission in the Hippocampus: Functional Implications of Central Corticosteroid Receptor Diversity

1998 • 200 citations

Characterization of Rat Brain Aldosterone Receptors Reveals High Affinity for Corticosterone

1983 • 188 citations

Evidence for a specific mineralocorticoid receptor in rat pituitary and brain

1980 • 187 citations

Corticosterone and dexamethasone act at different brain sites to inhibit adrenalectomy-induced adrenocorticotropin hypersecretion

1988 • 185 citations

The Role of Corticotropin‐Releasing Factor in the Pathophysiology of Affective and Anxiety Disorders: Laboratory and Clinical Studies

2007 • 182 citations

Type I and Type II Corticosteroid Receptor Gene Expression in the Rat: Effect of Adrenalectomy and Dexamethasone Administration

1989 • 178 citations

Exacerbation of Apoptosis in the Dentate Gyrus of the Aged Rat by Dexamethasone and the Protective Role of Corticosterone

1996 • 177 citations

Mineralocorticoid receptor-mediated changes in membrane properties of rat CA1 pyramidal neurons in vitro.

1990 • 176 citations

Glucocorticoids, hippocampal corticosteroid receptor gene expression and antidepressant treatment: relationship with spatial learning in young and aged rats

1995 • 174 citations

Hypothalamic-Pituitary-Adrenocortical Axis Changes in the Rat after Long-Term Treatment with the Reversible Monoamine Oxidase-A Inhibitor Moclobemide

1994 • 174 citations

Long-Term Intracerebroventricular Infusion of Corticotropin-Releasing Hormone Alters Neuroendocrine, Neurochemical, Autonomic, Behavioral, and Cytokine Responses to a Systemic Inflammatory Challenge

1997 • 170 citations

The Effect of Corticosterone on Reactivity to Spatial Novelty is Mediated by Central Mineralocorticosteroid Receptors

1994 • 167 citations

Mineralocorticoid hormones suppress serotonin-induced hyperpolarization of rat hippocampal CA1 neurons

1991 • 167 citations

Gluco- and antimineralocorticoid effects on human sleep: a role of central corticosteroid receptors

1991 • 163 citations

Cortisol Response to a Combined Dexamethasone‐Human Corticotrophin‐Releasing Hormone Challenge in Patients with Depression

1989 • 162 citations

Facilitation of feedback inhibition through blockade of glucocorticoid receptors in the hippocampus.

1997 • 157 citations

Corticosterone, brain mineralocorticoid receptors (MRS) and the activity of the hypothalamic-pituitary-adrenal (hpa) axis: The Lewis rat as an example of increased central MR capacity and a hyporesponsive HPA axis

1995 • 152 citations

Adrenal steroids and extinction behavior: Antagonism by progesterone, deoxycorticosterone and dexamethasone of a specific effect of corticosterone

1981 • 146 citations

Prenatal immune challenge alters the hypothalamic-pituitary-adrenocortical axis in adult rats.

1994 • 145 citations

Chronic treatment of rats with the antidepressant amitriptyline attenuates the activity of the hypothalamic-pituitary-adrenocortical system

1993 • 144 citations

Local administration of recombinant human interleukin-1 beta in the rat hippocampus increases serotonergic neurotransmission, hypothalamic-pituitary-adrenocortical axis activity, and body temperature.

1994 • 141 citations

Adrenocortical Steroids and the Brain

1987 • 141 citations

Differential activation of adrenal steroid receptors in neural and immune tissues of Sprague Dawley, Fischer 344, and Lewis rats

1995 • 116 citations

Hippocampal Mineralocorticoid, but Not Glucocorticoid, Receptors Modulate Anxiety-Like Behavior in Rats

1997 • 113 citations

Radioautographic study of the rat brain after injection of [1,2-3H]corticosterone

1975 • 112 citations

Species-Specificity of Corticosteroid Receptors in Hamster and Rat Brains

1987 • 109 citations

Binding Characteristics of Mineralocorticoid and Glucocorticoid Receptors in Dog Brain and Pituitary

1990 • 104 citations

Corticosteroids, receptors, and the organ‐specific functions of 11 β ‐hydroxysteroid dehydrogenase

1991 • 104 citations

Corticoid Receptors in Rat Brain: Evidence for an Aldosterone Receptor

1976 • 101 citations

Corticosterone Is Permissive to the Anxiolytic Effect That Results From the Blockade of Hippocampal Mineralocorticoid Receptors

1998 • 98 citations

Intraperitoneal Administration of Bacterial Endotoxin Enhances Noradrenergic Neurotransmission in the Rat Preoptic Area: Relationship with Body Temperature and Hypothalamic‐Pituitary‐Adrenocortical Axis Activity

1995 • 95 citations

Glucocorticoid receptor impairment alters CNS responses to a psychological stressor: an in vivo microdialysis study in transgenic mice

2000 • 95 citations

Neurotrophic ACTH analogue promotes plasticity of type I corticosteroid receptor in brain of senescent male rats

1988 • 95 citations

Circulating Regulatory Factors and Neuroendocrine Function

1990 • 90 citations

Why Dexamethasone Poorly Penetrates in Brain

1997 • 86 citations

Penetration of Dexamethasone into Brain Glucocorticoid Targets Is Enhanced in mdr1A P-Glycoprotein Knockout Mice

1998 • 85 citations

Glucocorticoid Receptor in Magnocellular Neurosecretory Cells

1988 • 83 citations

Increased neuroendocrine reactivity and decreased brain mineralocorticoid receptor-binding capacity in aged dogs.

1993 • 83 citations

Male Fischer 344/N rats show a progressive central impairment of the hypothalamic-pituitary-adrenal axis with advancing age.

1994 • 81 citations

Mineralcorticoid Receptor in Rat Kidney and Hippocampus: Characterization and Quantitation by Isoelectric Focusing

1983 • 81 citations

Age-related changes in the dog hypothalamic-pituitary-adrenocortical system: Neuroendocrine activity and corticosteroid receptors

1991 • 78 citations

The Role of the Hippocampal Mineralocorticoid and Glucocorticoid Receptors in the Hypothalamo-Pituitary-Adrenal Axis of the Aged Fisher Rat

1994 • 75 citations

Type I adrenal steroid receptors prolong hippocampal long-term potentiation

1994 • 75 citations

Hormonal regulation of corticosteroid-binding globulin biosynthesis in the male rat.

1992 • 74 citations

Local administration of recombinant human interleukin-1 beta in the rat hippocampus increases serotonergic neurotransmission, hypothalamic- pituitary-adrenocortical axis activity, and body temperature

1994 • 67 citations

Identification of Mineralocorticoid Binding Sites in Rat Brain by Competition Studies and Density Gradient Centrifugation

1983 • 66 citations

Mineralocorticoid Receptor also Modulates Basal Activity of Hypothalamus-Pituitary-Adrenocortical System in Humans

1998 • 66 citations

Localization and role of transcortin-like molecules in the anterior pituitary

1977 • 66 citations

Tumour necrosis factor‐α and interleukin‐2 differentially affect hippocampal serotonergic neurotransmission, behavioural activity, body temperature and hypothalamic–pituitary–adrenocortical axis activity in the rat

1998 • 65 citations

Antimineralocorticoid Canrenoate Enhances Secretory Activity of the Hypothalamus-Pituitary-Adrenocortical (HPA) Axis in Humans

1993 • 64 citations

High Affinity Binding and Regulatory Actions of Dexamethasone-Type I Receptor Complexes in Mouse Brain*

1989 • 55 citations

Central Action of Adrenal Steroids During Stress and Adaptation

1990 • 53 citations

Uptake and Binding of [³H]Aldosterone by the Anterior Pituitary and Brain Regions in Adrenalectomized Rats

1981 • 50 citations

Nuclear localization of aldosterone in rat brain cells assessed by autoradiography

1979 • 45 citations

Increased Stress-Induced Adrenocorticotropin Response after Long-Term Intracerebroventricular Treatment of Rats with Antisense Mineralocorticoid Receptor Oligodeoxynucleotides

1997 • 41 citations

Male Fischer 344/N rats show a progressive central impairment of the hypothalamic-pituitary-adrenal axis with advancing age

1994 • 40 citations

Brain corticosteroid receptor gene expression and neuroendocrine dynamics during aging

1991 • 38 citations

Adrenocortical Hyporesponsiveness and Glucocorticoid Feedback Resistance in Old Male Brown Norway Rats

1995 • 37 citations

Increased neuroendocrine reactivity and decreased brain mineralocorticoid receptor-binding capacity in aged dogs

1993 • 35 citations

Hormonal regulation of corticosteroid-binding globulin biosynthesis in the male rat

1992 • 31 citations

In vitro binding of tritiated glucocorticoids directly on unfixed rat brain sections

1984 • 19 citations

Type I Glucocorticoid Receptor Blockade Does Not Affect Baseline or Ovine Corticotropin-Releasing-Hormone-Stimulated Adrenocorticotropic Hormone and Cortisol Secretion

1994 • 15 citations