Different mechanisms in the tumorigenesis of proximal and distal colon cancers

The Hallmarks of Cancer

2000 • 27,569 citations

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

Lessons from Hereditary Colorectal Cancer

1996 • 4,900 citations

Genetic instabilities in human cancers

1998 • 4,165 citations

A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer.

1998 • 4,047 citations

Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis

1993 • 2,711 citations

Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma

1998 • 1,852 citations

Mutations of mitotic checkpoint genes in human cancers

1998 • 1,482 citations

Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines.

1997 • 1,465 citations

Aberrant CpG-island methylation has non-random and tumour-type–specific patterns

2000 • 1,344 citations

Somatic Frameshift Mutations in the BAX Gene in Colon Cancers of the Microsatellite Mutator Phenotype

1997 • 1,329 citations

Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon

1994 • 1,205 citations

Hypermutability and mismatch repair deficiency in RER+ tumor cells

1993 • 1,042 citations

Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer.

1998 • 998 citations

Folate and Carcinogenesis: An Integrated Scheme

2000 • 936 citations

Eukaryotic DNA mismatch repair

1999 • 860 citations

Clinical and pathological characteristics of sporadic colorectal carcinomas with DNA replication errors in microsatellite sequences.

1994 • 807 citations

Genomic instability in colorectal cancer: relationship to clinicopathological variables and family history.

1993 • 796 citations

De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells

1996 • 784 citations

Suppression of intestinal neoplasia by DNA hypomethylation

1995 • 712 citations

Allelic Loss of Chromosome 18q and Prognosis in Colorectal Cancer

1994 • 708 citations

GENETIC SUSCEPTIBILITY TO NONPOLYPOSIS COLORECTAL CANCER

1999 • 695 citations

Cancer risk associated with germline DNA mismatch repair gene mutations

1997 • 693 citations

Familial colorectal cancer in Ashkenazim due to a hypermutable tract in APC

1997 • 679 citations

Biallelic inactivation of hMLH 1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers

1998 • 629 citations

Aging and DNA methylation in colorectal mucosa and cancer.

1998 • 620 citations

Association of tumour site and sex with survival benefit from adjuvant chemotherapy in colorectal cancer

2000 • 556 citations

Microsatellite instability in colorectal cancer: different mutator phenotypes and the principal involvement of hMLH1.

1998 • 523 citations

Screening reduces colorectal cancer rate in families with hereditary nonpolyposis colorectal cancer

1995 • 516 citations

Genomic instability in repeated sequences is an early somatic event in colorectal tumorigenesis that persists after transformation

1994 • 496 citations

APC mutations in sporadic colorectal tumors: A mutational “hotspot” and interdependence of the “two hits”

2000 • 486 citations

Activating SRC mutation in a subset of advanced human colon cancers

1999 • 473 citations

CpG methylation is maintained in human cancer cells lacking DNMT1

2000 • 453 citations

Molecular nature of colon tumors in hereditary nonpolyposis colon cancer, familial polyposis, and sporadic colon cancer

1996 • 451 citations

Genetic mapping of a second locus predisposing to hereditary non–polyposis colon cancer

1993 • 434 citations

DNA methylation and genetic instability in colorectal cancer cells

1997 • 400 citations

Biology of the Adenomatous Polyposis Coli Tumor Suppressor

2000 • 391 citations

The type of somatic mutation at APC in familial adenomatous polyposis is determined by the site of the germline mutation: a new facet to Knudson's 'two-hit' hypothesis

1999 • 373 citations

APC mutations in colorectal tumors with mismatch repair deficiency.

1996 • 329 citations

Mismatch Repair Deficiency in Phenotypically Normal Human Cells

1995 • 314 citations

Role of DNA mismatch repair and p53 in signaling induction of apoptosis by alkylating agents

1999 • 314 citations

Selection, the mutation rate and cancer: Ensuring that the tail does not wag the dog

1999 • 309 citations

Mismatch repair defects in cancer

2000 • 292 citations

Loss of imprinting in normal tissue of colorectal cancer patients with microsatellite instability

1998 • 290 citations

Involvement of the Mismatch Repair System in Temozolomide-Induced Apoptosis

1998 • 275 citations

Neoplastic progression occurs through mutator pathways in hyperplastic polyposis of the colorectum

2000 • 255 citations

Genetic Analysis of an Inherited Predisposition to Colon Cancer in a Family with a Variable Number of Adenomatous Polyps

1990 • 254 citations

Alternative genetic pathways in colorectal carcinogenesis

1997 • 251 citations

Tumor spectrum in cancer family syndrome (hereditary nonpolyposis colorectal cancer)

1991 • 199 citations

Different genetic pathways to proximal and distal colorectal cancer influenced by sex-related factors

1997 • 184 citations

Frequent frameshift mutations of the TCF-4 gene in colorectal cancers with microsatellite instability.

1999 • 183 citations

hMutSα- and hMutLα-dependent phosphorylation of p53 in response to DNA methylator damage

1999 • 181 citations

Apoptosis induced by overexpression of hMSH2 or hMLH1.

1999 • 178 citations

Genomic instability, DNA methylation, and natural selection in colorectal carcinogenesis

1999 • 163 citations

Alleles of APC modulate the frequency and classes of mutations that lead to colon polyps

1998 • 157 citations

Colorectal cancer with and without microsatellite instability involves different genes

1999 • 137 citations

Epigenetic phenotypes distinguish microsatellite-stable and -unstable colorectal cancers

1999 • 129 citations

Analysis of masked mutations in familial adenomatous polyposis

1999 • 119 citations

APC mutation in the alternatively spliced region of exon 9 associated with late onset familial adenomatous polyposis

1995 • 117 citations

Colorectal Adenomas in the Lynch Syndromes

1990 • 102 citations

A common MSH2 mutation in English and North American HNPCC families: origin, phenotypic expression, and sex specific differences in colorectal cancer.

1999 • 99 citations

CHK1 frameshift mutations in genetically unstable colorectal and endometrial cancers

1999 • 92 citations

Natural history of ampullary adenoma in familial adenomatous polyposis: reconfirmation of benign nature during extended surveillance

2000 • 88 citations

Carcinogenesis and Natural Selection: A New Perspective to the Genetics and Epigenetics of Colorectal Cancer

1999 • 82 citations

Missense mutations in hMLH1 associated with colorectal cancer

1999 • 75 citations

Defects in mismatch repair occur afterAPC mutations in the pathogenesis of sporadic colorectal tumours

1998 • 75 citations

Epidemiology of Familial Adenomatous Polyposis in Sweden: Changes over Time and Differences in Phenotype between Males and Females

1999 • 73 citations

Notable intrafamilial phenotypic variability in a kindred with familial adenomatous polyposis and an APC mutation in exon 9

1999 • 63 citations

Sex differences in colorectal cancer mortality in Europe, 1955–1996

2000 • 62 citations

Alterations in DNA methylation in human colon neoplasia

1987 • 61 citations

Population risk and physiological rate parameters for colon cancer. The union of an explicit model for carcinogenesis with the public health records of the United States

2000 • 59 citations

The identical 5' splice-site acceptor mutation in five attenuated APC families from Newfoundland demonstrates a founder effect

1999 • 51 citations

K-ras codon 12 mutation determines the polypoid growth of colorectral cancer.

1998 • 47 citations

Menopause and colorectal cancer

2000 • 43 citations

Proximal shift of colorectal cancer in the Australian Capital Territory over 20 years

2000 • 26 citations

Genomic instability and target gene mutations in colon cancers with different degrees of allelic shifts

2000 • 26 citations