Complete degradation of type X collagen requires the combined action of interstitial collagenase and osteoclast-derived cathepsin-B.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

[41] Cathepsin B, cathepsin H, and cathepsin L

1981 • 1,678 citations

SV40-transformed Human Lung Fibroblasts Secrete a 92-kDa Type IV Collagenase Which Is Identical to That Secreted by Normal Human Macrophages

1989 • 1,122 citations

Modulation of Osteoclast Differentiation

1992 • 1,014 citations

Microelectrode studies on the acid microenvironment beneath adherent macrophages and osteoclasts*1

1988 • 887 citations

Human 92- and 72-kilodalton type IV collagenases are elastases.

1991 • 550 citations

Matrix metalloproteinase degradation of elastin, type IV collagen and proteoglycan. A quantitative comparison of the activities of 95 kDa and 72 kDa gelatinases, stromelysins-1 and -2 and punctuated metalloproteinase (PUMP)

1991 • 454 citations

Immunohistochemical localization of short chain cartilage collagen (type X) in avian tissues.

1985 • 451 citations

Degradation of extracellular-matrix proteins by human cathepsin B from normal and tumour tissues

1992 • 417 citations

Cathepsin B1. A lysosomal enzyme that degrades native collagen

1974 • 405 citations

Human skin collagenase: isolation of precursor and active forms from both fibroblast and organ cultures

1977 • 387 citations

The collagen substrate specificity of human skin fibroblast collagenase.

1981 • 371 citations

Regulation of Body Temperature

1986 • 360 citations

Nucleotide and predicted amino acid sequences of cloned human and mouse preprocathepsin B cDNAs.

1986 • 245 citations

In vivo and in vitro evidence for the involvement of cysteine proteinases in bone resorption

1984 • 229 citations

Effects of matrix macromolecules on chondrocyte gene expression: synthesis of a low molecular weight collagen species by cells cultured within collagen gels.

1982 • 220 citations

A unique low molecular weight collagen secreted by cultured chick embryo chondrocytes.

1982 • 202 citations

Rat procathepsin B. Proteolytic processing to the mature form in vitro.

1992 • 181 citations

A short chain (pro)collagen from aged endochondral chondrocytes. Biochemical characterization.

1983 • 164 citations

A comparison of four cathepsins (B, L, N and S) with collagenolytic activity from rabbit spleen

1988 • 158 citations

Susceptibility of the cartilage collagens types II, IX and XI to degradation by the cysteine proteinases, cathepsins B and L

1990 • 147 citations

Differential susceptibility of type X collagen to cleavage by two mammalian interstitial collagenases and 72-kDa type IV collagenase.

1990 • 121 citations

Synthesis of a low molecular weight collagen by chondrocytes from the presumptive calcification region of the embryonic chick sterna: the influence of culture with collagen gels.

1984 • 116 citations

Type X collagen contains two cleavage sites for a vertebrate collagenase.

1986 • 106 citations

Type X collagen synthesis during endochondral ossification in fracture repair.

1987 • 100 citations

Thermal stability of the triple helix of type I procollagen and collagen. Precautions for minimizing ultraviolet damage to proteins during circular dichroism studies

1979 • 97 citations

Cartilage proteoglycan aggregate is degraded more extensively by cathepsin L than by cathepsin B.

1990 • 94 citations

Characterization of recombinant rat cathepsin B and nonglycosylated mutants expressed in yeast. New insights into the pH dependence of cathepsin B-catalyzed hydrolyses.

1992 • 89 citations

An improved assay for proteases and polysaccharidases employing a cartilage proteoglycan substrate entrapped in polyacrylamide particles

1980 • 83 citations

12-o-Tetradecanoyl-phorbol-13-acetate-differentiated U937 cells express a macrophage-like profile of neutral proteinases. High levels of secreted collagenase and collagenase inhibitor accompany low levels of intracellular elastase and cathepsin G.

1986 • 74 citations

The distribution of cathespin b in human tissues

1985 • 68 citations

Denaturation-renaturation properties of two molecular forms of short-chain cartilage collagen

1984 • 57 citations

The Dissolution of Insoluble Bovine Collagens by Cathepsin BI, Collagenolytic Cathepsin and Pepsin: The influence of collagen type, age and chemical purity on susceptibility

1977 • 50 citations

Extracellular-matrix degradation at acid pH. Avian osteoclast acid collagenase isolation and characterization

1993 • 49 citations

The potential role of human kidney cortex cysteine proteinases in glomerular basement membrane degradation

1989 • 42 citations

Characterization of Porcine Plasma Fibronectin and Its Fragmentation by Porcine Liver Cathepsin B1

1981 • 34 citations

Increased cathepsin B-like activity in alveolar macrophages and bronchoalveolar lavage fluid from smokers.

1986 • 31 citations

Cleavage of Collagen Type X by Human Synovial Collagenase and Neutrophil Elastase

1989 • 29 citations

Identification of disulphide‐bonded type X procollagen polypeptides in embryonic chick chondrocyte culture

1986 • 27 citations

Degradation of Cartilage Collagens Type II, IX, X and XI by Enzymes Derived from Human Articular Chondrocytes

1990 • 23 citations

The cellular organization of fibroblastic cells and macrophages at regions of uncalcified cartilage resorption in the embryonic chick femur as revealed by alkaline acid phosphatase histochemistry

1982 • 20 citations