Engineering of Glycerol-stimulated Insulin Secretion in Islet Beta Cells

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines.

1992 • 1,128 citations

A simple technique for the rescue of early region I mutations into infectious human adenovirus type 5

1988 • 606 citations

Adenovirus-mediated transfer of low density lipoprotein receptor gene acutely accelerates cholesterol clearance in normal mice.

1993 • 531 citations

GLYCEROL DISSIMILATION AND ITS REGULATION IN BACTERIA

1976 • 530 citations

METABOLIC COUPLING FACTORS IN PANCREATIC β-CELL SIGNAL TRANSDUCTION

1995 • 529 citations

Pancreatic islet glucose metabolism and regulation of insulin secretion

1986 • 506 citations

Malonyl-CoA and long chain acyl-CoA esters as metabolic coupling factors in nutrient-induced insulin secretion.

1992 • 440 citations

Mechanism of glucose-induced insulin secretion.

1980 • 425 citations

Glycolysis Preferentially Inhibits ATP-Sensitive K ⁺ Channels in Isolated Guinea Pig Cardiac Myocytes

1987 • 391 citations

Essentiality of circulating fatty acids for glucose-stimulated insulin secretion in the fasted rat.

1996 • 373 citations

Pancreatic β-Cells in Obesity

1995 • 276 citations

A Role for Malonyl-CoA in Glucose-Stimulated Insulin Secretion from Clonal Pancreatic β-Cells

1989 • 259 citations

Adenovirus-mediated transfer of the muscle glycogen phosphorylase gene into hepatocytes confers altered regulation of glycogen metabolism.

1992 • 248 citations

The high Km glucose transporter of islets of Langerhans is functionally similar to the low affinity transporter of liver and has an identical primary sequence.

1990 • 204 citations

High content of mitochondrial glycerol-3-phosphate dehydrogenase in pancreatic islets and its inhibition by diazoxide.

1981 • 189 citations

More Direct Evidence for a Malonyl-CoA–Carnitine Palmitoyltransferase I Interaction as a Key Event in Pancreatic β-Cell Signaling

1994 • 172 citations

Elusive Proximal Signals of β-Cells for Insulin Secretion

1990 • 151 citations

Overexpression of hexokinase I in isolated islets of Langerhans via recombinant adenovirus. Enhancement of glucose metabolism and insulin secretion at basal but not stimulatory glucose levels.

1994 • 151 citations

Substrate-dependent changes in mitochondrial function, intracellular free calcium concentration and membrane channels in pancreatic β-cells

1993 • 147 citations

Dependence on NADH produced during glycolysis for beta-cell glucose signaling

1994 • 146 citations

Inhibition of acyl-CoA synthetase by triacsins.

1987 • 132 citations

Inhibition of acyl-CoA synthetase by triacsins

1987 • 122 citations

Differential Effects of Overexpressed Glucokinase and Hexokinase I in Isolated Islets

1996 • 108 citations

Activation of Stimulus-Secretion Coupling in Pancreatic β-Cells by Specific Products of Glucose Metabolism

1996 • 104 citations

GLUT-2 gene transfer into insulinoma cells confers both low and high affinity glucose-stimulated insulin release. Relationship to glucokinase activity

1994 • 95 citations

Escherichia coli glycerol kinase. Cloning and sequencing of the glpK gene and the primary structure of the enzyme.

1988 • 84 citations

Expression ofreg/PSP, a Pancreatic Exocrine Gene: Relationship to Changes in Islet β-Cell Mass

1991 • 78 citations

The glucose-phosphorylating capacity of liver as measured by three independent assays. Implications for the mechanism of hepatic glycogen synthesis.

1986 • 69 citations

Insulin release in pancreatic islets by a glycolytic and a krebs cycle intermediate: Contrasting patterns of glyceraldehyde phosphate and succinate

1990 • 56 citations

Calcium Activation of Pancreatic Islet Mitochondrial Glycerol Phosphate Dehydrogenase

1982 • 21 citations

Hexose metabolism in pancreatic islets stimulation by d-glucose of [2-3H]glycerol detritiation

1988 • 21 citations

Glycerol phosphorylation and oxidation in pancreatic islets

1987 • 10 citations