A Novel Mechanism for Cyclic Adenosine 3′,5′-Monophosphate Regulation of Gene Expression by CREB-Binding Protein

The Transcriptional Coactivators p300 and CBP Are Histone Acetyltransferases

1996 • 2,873 citations

Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133

1989 • 2,486 citations

A CBP Integrator Complex Mediates Transcriptional Activation and AP-1 Inhibition by Nuclear Receptors

1996 • 2,183 citations

Phosphorylated CREB binds specifically to the nuclear protein CBP

1993 • 2,039 citations

Nuclear protein CBP is a coactivator for the transcription factor CREB

1994 • 1,447 citations

Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1

1990 • 1,211 citations

Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor.

1994 • 1,046 citations

A tissue-specific transcription factor containing a homeodomain specifies a pituitary phenotype

1988 • 998 citations

The pituitary-specific transcription factor GHF-1 is a homeobox-containing protein

1988 • 771 citations

Activation of cAMP and mitogen responsive genes relies on a common nuclear factor

1994 • 730 citations

Adenoviral ElA-associated protein p300 as a functional homologue of the transcriptional co-activator CBP

1995 • 578 citations

RNA Helicase A Mediates Association of CBP with RNA Polymerase II

1997 • 532 citations

POU-domain transcription factors: pou-er-ful developmental regulators.

1991 • 461 citations

A pituitary POU domain protein, Pit-1, activates both growth hormone and prolactin promoters transcriptionally.

1989 • 352 citations

Transcriptional regulation of growth hormone gene expression by growth hormone-releasing factor

1983 • 305 citations

Mechanism of Thyrotropin Releasing Hormone Stimulation of Pituitary Hormone Secretion

1986 • 292 citations

Signal-specific co-activator domain requirements for Pit-1 activation

1998 • 284 citations

Dissection of functional domains of the pituitary-specific transcription factor GHF-1

1989 • 252 citations

Expression cloning of a cDNA encoding the mouse pituitary thyrotropin-releasing hormone receptor.

1990 • 225 citations

Autoregulation of pit-1 gene expression mediated by two cis-active promoter elements

1990 • 224 citations

Cyclic AMP responsiveness of human gonadotropin-alpha gene transcription is directed by a repeated 18-base pair enhancer. Alpha-promoter receptivity to the enhancer confers cell-preferential expression.

1987 • 216 citations

Regulation of the pituitary-specific homeobox gene GHF1 by cell-autonomous and environmental cues

1990 • 215 citations

Variable Effects of Phosphorylation of Pit-1 Dictated by the DNA Response Elements

1991 • 206 citations

Adaptor-mediated Recruitment of RNA Polymerase II to a Signal-dependent Activator

1996 • 199 citations

Both Isoforms of the cAMP-dependent Protein Kinase Catalytic Subunit Can Activate Transcription of the Prolactin Gene

1989 • 162 citations

Thyrotropin-releasing hormone regulation of human TSHB expression: role of a pituitary-specific transcription factor (Pit-1/GHF-1) and potential interaction with a thyroid hormone-inhibitory element.

1991 • 132 citations

Differential splicing of the GHF1 primary transcript gives rise to two functionally distinct homeodomain proteins.

1992 • 121 citations

Functional isoforms of Pit-1 generated by alternative messenger RNA splicing.

1992 • 97 citations

An alternatively spliced Pit-1 isoform altered in its ability to trans-activate

1992 • 88 citations

Role of a pituitary-specific transcription factor (pit-1/GHF-1) or a closely related protein in cAMP regulation of human thyrotropin-beta subunit gene expression.

1992 • 65 citations

Pit-1 binding sites mediate transcriptional responses to cyclic adenosine 3',5'-monophosphate through a mechanism that does not require inducible phosphorylation of Pit-1.

1994 • 51 citations

Analysis of functional cooperativity between individual transcription-stimulating elements in the proximal region of the rat prolactin gene.

1992 • 41 citations

Cyclic adenosine 3',5'-monophosphate activation of the rat prolactin promoter is restricted to the pituitary-specific cell type.

1992 • 38 citations

A Pit-1 phosphorylation mutant can mediate both basal and induced prolactin and growth hormone promoter activity.

1994 • 37 citations

G(i) alpha 2- and G(o) alpha-mediated signaling in the Pit-1-dependent inhibition of the prolactin gene promoter. Control of transcription by dopamine D2 receptors.

1994 • 35 citations

Analysis of functional cooperativity between individual transcription- stimulating elements in the proximal region of the rat prolactin gene

1992 • 18 citations

Extinction of prolactin gene expression in somatic cell hybrids is correlated with the repression of the pituitary-specific trans-activator GHF-1/Pit-1.

1992 • 15 citations

Rat Pit-1 Stimulates Transcription in Vitro by Influencing Preinitiation Complex Assembly

1995 • 14 citations

Cyclic adenosine 3',5'-monophosphate activation of the rat prolactin promoter is restricted to the pituitary-specific cell type

1992 • 12 citations

Extinction of prolactin gene expression in somatic cell hybrids is correlated with the repression of the pituitary-specific trans- activator GHF-1/Pit-1

1992 • 5 citations