Depression in Schizophrenia: Perspective in the Era of “Atypical” Antipsychotic Agents

The Positive and Negative Syndrome Scale (PANSS) for Schizophrenia

1987 • 19,723 citations

A New Depression Scale Designed to be Sensitive to Change

1979 • 12,729 citations

Dementia Praecox or the Group of Schizophrenias

1951 • 4,409 citations

Clozapine for the Treatment-Resistant Schizophrenic

1988 • 4,030 citations

Negative v Positive Schizophrenia

1982 • 2,003 citations

Dopamine in schizophrenia: a review and reconceptualization

1991 • 1,963 citations

Vulnerability: A new view of schizophrenia.

1977 • 1,961 citations

Persuasion and Healing

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Classification of typical and atypical antipsychotic drugs on the basis of dopamine D-1, D-2 and serotonin2 pKi values.

1989 • 1,313 citations

Risperidone in the treatment of schizophrenia

1994 • 1,205 citations

Neuroleptics and operant behavior: The anhedonia hypothesis

1982 • 1,021 citations

A Heuristic Vulnerability/Stress Model of Schizophrenic Episodes

1984 • 1,002 citations

Family Psychoeducation, Social Skills Training, and Maintenance Chemotherapy in the Aftercare Treatment of Schizophrenia

1986 • 925 citations

Olanzapine versus haloperidol in the treatment of schizophrenia and schizoaffective and schizophreniform disorders: results of an international collaborative trial

1997 • 906 citations

A Canadian Multicenter Placebo-Controlled Study of Fixed Doses of Risperidone and Haloperidol in the Treatment of Chronic Schizophrenic Patients

1993 • 884 citations

Olanzapine versus Placebo and Haloperidol

1996 • 788 citations

Symptoms of Schizophrenia

1995 • 734 citations

Double-Blind Comparison of Olanzapine Versus Risperidone in the Treatment of Schizophrenia and Other Psychotic Disorders

1997 • 722 citations

The Effects of Risperidone on the Five Dimensions of Schizophrenia Derived by Factor Analysis

1997 • 705 citations

Endogenomorphic Depression

1974 • 582 citations

Risperidone in the Treatment of Patients with Chronic Schizophrenia: a Multi-National, Multi-Centre, Double-Blind, Parallel-Group Study versus Haloperidol

1995 • 558 citations

Schizophrenics Kill Themselves Too: A Review of Risk Factors for Suicide

1990 • 513 citations

A Comparison of Clozapine and Haloperidol in Hospitalized Patients with Refractory Schizophrenia

1997 • 512 citations

THE ACUTE SCHIZOAFFECTIVE PSYCHOSES

1933 • 508 citations

Nicotine Dependence in Schizophrenia: Clinical Phenomena and Laboratory Findings

1998 • 502 citations

Treatment of Negative Symptoms

1985 • 500 citations

Relapse in schizophrenia

1980 • 460 citations

Reduction of suicidality during clozapine treatment of neuroleptic- resistant schizophrenia: impact on risk-benefit assessment

1995 • 446 citations

'Akinetic Depression' in Schizophrenia

1978 • 388 citations

Ziprasidone 80 mg/day and 160 mg/day in the Acute Exacerbation of Schizophrenia and Schizoaffective Disorder A 6-Week Placebo-Controlled Trial

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Depression, demoralization and control over psychotic illness: a comparison of depressed and non-depressed patients with a chronic psychosis

1993 • 356 citations

Cholinergic Hyperactivity and Negative Schizophrenic Symptoms

1989 • 353 citations

Symptoms, subtype, and suicidality in patients with schizophrenia spectrum disorders

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Five factor model of schizophrenia: replication across samples

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Mortality in Current and Former Users of Clozapine

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Postpsychotic Depression in Schizophrenia

1976 • 318 citations

Depression in first-episode schizophrenia

1993 • 312 citations

Negative symptoms: a path analytic approach to a double-blind, placebo- and haloperidol-controlled clinical trial with olanzapine

1997 • 302 citations

Ziprasidone (CP-88,059): a new antipsychotic with combined dopamine and serotonin receptor antagonist activity.

1995 • 299 citations

Suicide and schizophrenia: a nationwide psychological autopsy study on age- and sex-specific clinical characteristics of 92 suicide victims with schizophrenia

1997 • 296 citations

Subjective Response to Neuroleptics in Schizophrenia

1993 • 280 citations

ICI 204,636, an Atypical Antipsychotic

1996 • 275 citations

Ziprasidone 40 and 120 mg/day in the acute exacerbation of schizophrenia and schizoaffective disorder: a 4-week placebo-controlled trial

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Depressive Signs and Symptoms in Schizophrenia

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Outpatient Maintenance of Chronic Schizophrenic Patients with Long-acting Fluphenazine: Double-blind Placebo

1973 • 262 citations

Stages of onset of schizophrenic psychosis

1978 • 260 citations

Akinesia

1975 • 257 citations

Mechanisms of action of atypical antipsychotic drugs

1991 • 254 citations

Relationships Among Negative, Positive, and Depressive Symptoms in Schizophrenia and Psychotic Depression

1996 • 231 citations

'Revealed' Depression and Drug Treatment for Schizophrenia

1981 • 231 citations

The many faces of Akathisia

1975 • 230 citations

Platelet serotonin-2 receptor binding sites in depression and suicide

1990 • 223 citations

Diagnosis of Secondary Depression in Schizophrenia: Implications for DSM-IV

1991 • 214 citations

Suicide attempts associated with akathisia

1985 • 206 citations

Depression and demoralization: Phenomenologic differences and research perspectives

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Are schizophrenia and affective disorder related? A selective literature review

1992 • 201 citations

A comparative controlled trial of pimozide and fluphenazine decanoate in the continuation therapy of schizophrenia

1978 • 198 citations

When Symptoms Persist: Choosing Among Alternative Somatic Treatments for Schizophrenia

1991 • 179 citations

Fluvoxamine improves negative symptoms in treated chronic schizophrenia: An add-on double-blind, placebo-controlled study

1992 • 174 citations

Risperidone in the treatment of affective illness and obsessive-compulsive disorder.

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Clozapine: Efficacy and Safety

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The Nature and Prevalence of Depression in Chronic Schizophrenic In-patients

1989 • 164 citations

Side effect profiles of new antipsychotic agents.

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Severe Depressive Mood Changes Following Slow-release Intramuscular Fluphenazine Injection

1969 • 157 citations

Adjunctive Imipramine in the Treatment of Postpsychotic Depression

1987 • 147 citations

A path-analytical approach to differentiate between direct and indirect drug effects on negative symptoms in schizophrenic patients

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A placebo-controlled trial of fluoxetine added to neuroleptic in patients with schizophrenia

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Treatment of Schizoaffective Disorder and Schizophrenia With Mood Symptoms

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Development and Prediction of Postpsychotic Depression in Neuroleptic-Treated Schizophrenics

1982 • 137 citations

A Double-Blind, Controlled Comparison of the Novel Antipsychotic Olanzapine versus Haloperidol or Placebo on Anxious and Depressive Symptoms Accompanying Schizophrenia

1998 • 136 citations

Prodromal signs and symptoms of schizophrenic relapse.

1988 • 133 citations

Depression in Schizophrenia: Are Neuroleptics, Akinesia, or Anhedonia Involved?

1994 • 133 citations

Depressive symptoms in schizophrenia: Comprehensive differential diagnosis

1988 • 130 citations

The Pharmacologic Treatment of Neuroleptic-Induced Akathisia

1990 • 123 citations

Major tranquillisers used as antidepressants

1982 • 120 citations

Akinesia: A syndrome common to parkinsonism, retarded depression, and negative symptoms of schizophrenia

1992 • 118 citations

Suicide Associated with Akathisia and Depot Fluphenazine Treatment

1983 • 116 citations

Postpsychotic depression and negative symptoms: an investigation of syndromal overlap

1988 • 116 citations

Are Prophylactic Antiparkinson Drugs Necessary?

1978 • 112 citations

The Significance of Depression in the Prediction of Relapse in Chronic Schizophrenia

1988 • 110 citations

Trial of fluoxetine added to neuroleptics for treatment-resistant schizophrenic patients

1990 • 109 citations

Adjunctive fluoxetine in the treatment of negative symptoms in chronic schizophrenic patients

1994 • 109 citations

Conventional versus atypical neuroleptics: subjective quality of life in schizophrenic patients

1997 • 106 citations

Akathisia: Prevalence and Associated Dysphoria in an In-patient Population with Chronic Schizophrenia

1994 • 106 citations

Clozapine in severe mood disorders.

1995 • 104 citations

Clinical predictors of acute risperidone response in schizophrenia, schizoaffective disorder, and psychotic mood disorders.

1995 • 104 citations

Antidepressant Usage in Schizophrenia

1991 • 101 citations

Double-blind Comparison of Risperidone and Haloperidol in Schizophrenic and Schizoaffective Psychoses

1993 • 99 citations

The Composition of the Negative Syndrome of Chronic Schizophrenia

1993 • 97 citations

Prodromal Symptoms in Schizophrenia

1994 • 96 citations

Risperidone in the Treatment of Disorders with a combined Psychotic and Depressive Syndrome - A Functional Approach

1992 • 91 citations

Maintenance Imipramine Therapy for Secondary Depression in Schizophrenia

1994 • 87 citations

Quality of Life in Schizophrenia: Insight and Subjective Response to Neuroleptics

1998 • 85 citations

Pharmacotherapy of Impaired Affect in Recovering Schizophrenic Patients

1995 • 84 citations

Citalopram as an adjuvant in chronic schizophrenia: a double‐blind placebo‐controlled study

1996 • 84 citations

Dysphoric and depressive symptoms in chronic schizophrenia

1989 • 82 citations

Correlations over time between dysphoric mood and symptomatology in schizophrenia

1994 • 82 citations

The course of depressive symptoms in predicting relapse in schizophrenia: a double-blind, randomized comparison of olanzapine and risperidone

1999 • 81 citations

Affective Syndromes, Psychotic Features, and Prognosis

1990 • 79 citations

Risperidone in the treatment of schizophrenia: a meta-analysis of randomized controlled trials

1997 • 79 citations

The heterogeneity of schizoaffective disorder: implications for treatment

1988 • 78 citations

Should we consider mood disturbance in schizophrenia as an important determinant of quality of life?

1999 • 77 citations

Augmentation With Fluvoxamine But Not Maprotiline Improves Negative Symptoms in Treated Schizophrenia

1998 • 76 citations

Psychiatric diagnosis and a typology of clinical drug effects

1968 • 74 citations

The temporal relationship between depressive and psychotic symptoms in recent-onset schizophrenia

1990 • 72 citations

Acute and long-term effectiveness of clozapine in treatment-resistant psychotic depression

1996 • 72 citations

Depressive States Occurring During the Neuroleptic Treatment of Schizophrenia

1982 • 68 citations

The Causality of Depression in Schizophrenia

1983 • 63 citations

Aspects of dysphoria and symptoms of schizophrenia

1998 • 60 citations

The clinical course of depressive symptoms in schizophrenia

1988 • 58 citations

Dysphoric mood and symptomatology in schizophrenia

1991 • 58 citations

Measurement of Depression and Negative Symptoms in Schizophrenia

1992 • 55 citations

Genetic factors in the response to neuroleptics in schizophrenia: a psychopharmacogenetic study

1981 • 54 citations

Treatment of Negative Symptoms in Schizophrenia and Schizoaffective Disorder by Selegiline Augmentation of Antipsychotic Medication

1996 • 52 citations

The Problem of Post-Psychotic Schizophrenie Depressions and their Pharmacological Induction

1975 • 50 citations

The frequency of associations between positive and negative symptoms and dysphoria in schizophrenia

1995 • 49 citations

Depression and the experience of psychological deficits in schizophrenia

1993 • 49 citations

The negative symptoms of schizophrenia and the monoamine oxidase inhibitors

1987 • 47 citations

Serotonin, dopamine and their interactions in schizophrenia

1993 • 45 citations

Schizophrenic patients with depression: Psychopathological profiles and relationship with negative symptoms

1991 • 44 citations

Cholinergic Hypothesis of Depression

1989 • 43 citations

Adjunctive Antidepressant Drug Therapies in the Treatment of Negative Symptoms of Schizophrenia

1996 • 43 citations

The new antipsychotics, and their potential for early intervention in schizophrenia

1997 • 42 citations

Effect of neuroleptic treatment on depressive symptoms in acute schizophrenic episodes

1997 • 42 citations

Lithium Combined with Haloperidol in Schizophrenic Patients

1988 • 41 citations

Depressive syndromes in schizophrenic patients after discharge from hospital

1990 • 39 citations

The expanding indications for clozapine.

1997 • 39 citations

Adjunctive use of olanzapine in mood disorders: five case reports.

1997 • 38 citations

Long‐term treatment of mood disorders in schizophrenia

1995 • 37 citations

Pharmacogenic depression among outpatient schizophrenic patients: a failure to substantiate.

1984 • 35 citations

Depressions in schizophrenia: Some observations on prevalence, etiology, and treatment

1981 • 32 citations

Depressive symptoms in acute schizophrenic inpatients

1997 • 30 citations

Effectiveness of lithium in schizophrenia: do we really have an answer?

1989 • 30 citations

The use of monoamine oxidase inhibitors in schizophrenia.

1980 • 29 citations

Depressive symptoms in chronic schizophrenic patients after withdrawal of long-acting neuroleptics.

1983 • 28 citations

Adjunctive Trazodone in the Treatment of Negative Symptoms of Schizophrenia

1994 • 27 citations

Dimensionality of depression in acute schizophrenia: a methodological study using the Bech-Rafaelsen Melancholia Scale (BRMES)

1998 • 27 citations

Negative Symptomatology in Schizophrenic Outpatients

1992 • 27 citations

Changes in Single Symptoms and Separate Factors of the Schizophrenic Syndrome after Treatment with Risperidone or Haloperidol

1994 • 25 citations

Post psychotic depression: The Fulbourn cohort

1987 • 23 citations

Subjective experiences of schizophrenic patients treated with antipsychotic medication

1998 • 21 citations

Fluphenazine decanoate dose and severity of depression in patients with post-psychotic depression

1988 • 19 citations

Depressive symptoms and schizophrenia a psychopharmacological approach.

1995 • 15 citations

Do neuroleptics cause depression?

1984 • 15 citations

Deleted Work

1955 • 0 citations