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Hydroxylation of Phenol to Hydroquinone Catalyzed by A Human Myeloperoxidase-Superoxide Complex: Possible Implications In Benzene-Induced Myelotoxicity

Data up to Jan 2025

Published1991
Citations40
References52

Total Citations Per Year

Abstract

References (52)

Free radicals in biology and medicine

1991 • 17,840 citations

Superoxide Dismutase

1969 • 12,578 citations

A JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

1909 • 6,516 citations

Free Radicals in Biology and Medicine

1990 • 4,962 citations

Iron Ion-dependent Modification of Bases in DNA by the Superoxide Radical-generating System Hypoxanthine/Xanthine Oxidase

1989 • 363 citations

The chemical nature of the second hydrogen peroxide compound formed by cytochrome c peroxidase and horseradish peroxidase. 1. Titration with reducing agents

1953 • 300 citations

Lignin synthesis: The generation of hydrogen peroxide and superoxide by horseradish peroxidase and its stimulation by manganese (II) and phenols

1978 • 290 citations

The kinetics and stoichiometry of the transition from the primary to the secondary peroxidase peroxide complexes

1952 • 281 citations

Superoxide-dependent formation of hydroxyl radicals: Detection of hydroxyl radicals by the hydroxylation of aromatic compounds

1981 • 234 citations

Benzene disposition in the rat after exposure by inhalation

1979 • 219 citations

Role of the arene oxide-oxepin system in the metabolism of aromatic substrates

1968 • 215 citations

[52] Antimicrobial activity of myeloperoxidase

1984 • 208 citations

Peroxidase-dependent metabolism of benzene's phenolic metabolites and its potential role in benzene toxicity and carcinogenicity.

1989 • 201 citations

Recent Advances in the Metabolism and Toxicity of Benzene

1987 • 196 citations

Effects of toluene on the metabolism, disposition and hemopoietic toxicity of [3H]benzene

1977 • 187 citations

The mechanism of oxyperoxidase formation from ferryl peroxidase and hydrogen peroxide.

1987 • 168 citations

The spectra of the enzyme-substrate complexes of catalase and peroxidase

1952 • 163 citations

Partial hepatectomy reduces both metabolism and toxicity of benzene

1979 • 158 citations

Production of the superoxide adduct of myeloperoxidase (compound III) by stimulated human neutrophils and its reactivity with hydrogen peroxide and chloride

1985 • 153 citations

On the haematin compound of peroxidase

1937 • 146 citations

Identification of ethanol-inducible P450 isozyme 3a (P450IIE1) as a benzene and phenol hydroxylase

1989 • 134 citations

Multi-step metabolic activation of benzene. Effect of superoxide dismutase on covalent binding to microsomal macromolecules, and identification of glutathione conjugates using high pressure liquid chromatography and field desorption mass spectrometry

1980 • 121 citations

Generation of hydrogen peroxide, superoxide and hydroxyl radicals during the oxidation of dihydroxyfumaric acid by peroxidase

1977 • 120 citations

Phenobarbital-induced protection against toxicity of toluene and benzene in the rat

1971 • 116 citations

The generation of utilization of chlorinated oxidants by human neutrophils

1986 • 110 citations

The oxidation of phenol and its reaction product by horseradish peroxidase and hydrogen peroxide

1973 • 100 citations

Hydroxylation: the activation of oxygen by peroxidase

1957 • 99 citations

Biotransformation of phenol to hydroquinone and catechol by rat liver microsomes.

1983 • 99 citations

Benzene Carcinogenicity

2017 • 98 citations

Molecular Pharmacology

2012 • 92 citations

3H-Benzene metabolism in rabbit bone marrow

1979 • 91 citations

Benzene metabolism in mouse liver microsomes

1973 • 91 citations

Metabolic activation of phenol by human myeloperoxidase and horseradish peroxidase.

1986 • 89 citations

Hydroxylation of p-coumaric acid by horseradish peroxidase. The role of superoxide and hydroxyl radicals

1976 • 86 citations

Peroxidase: the properties and uses of a versatile enzyme and of some related catalysts.

1964 • 82 citations

Metabolism of hydroquinone by human myeloperoxidase: Mechanisms of stimulation by other phenolic compounds

1991 • 79 citations

Iron and xanthine oxidase catalyze formation of an oxidant species distinguishable from OH.: Comparison with the Haber-Weiss reaction

1986 • 78 citations

Oxidation of catechol by horseradish peroxidase and human leukocyte peroxidase: Reactions of o-benzoquinone and o-benzosemiquinone*1

1988 • 74 citations

Horseradish peroxidase-mediated oxidation of phenol

1982 • 71 citations

Horseradish peroxidase-catalyzed hydroxylations: mechanistic studies

1986 • 68 citations

THE THIRD INTERMEDIATE COMPOUND OF HORSERADISH PEROXIDASE AND HYDROGEN PEROXIDE

1953 • 64 citations

Toxic effects of benzene and benzene metabolites on granulopoietic stem cells and bone marrow cellularity in mice

1981 • 64 citations

SUPEROXIDE AND PEROXIDASE-CATALYSED REACTIONS. OXIDATION OF DIHYDROXYFUMARATE, NADH AND DITHIOTHREITOL BY HORSERADISH PEROXIDASE*

1978 • 55 citations

Identification and induction of cytochromes P450, P450IIE1 and P450IA1 in rabbit bone marrow.

1989 • 54 citations

The reactions of horseradish peroxidase, lactoperoxidase, and myeloperoxidase with enzymatically generated superoxide

1989 • 51 citations

Reaction of compound III of myeloperoxidase with ascorbic acid.

1990 • 41 citations

Purification and some properties of peroxidases of rat bone marrow

1987 • 38 citations

Kinetic studies on benzene metabolism in rat liver—possible presence of three forms of benzene metabolizing enzymes in the liver

1987 • 35 citations

Phenol oxidation product(s), formed by a peroxidase reaction, that bind to DNA

1985 • 35 citations

Mechanisms of catechol formation from aromatic compounds in isolated rat hepatocytes.

1985 • 30 citations

Characterization of the benzene monooxygenase system in rabbit bone marrow

1984 • 28 citations

Stimulation of the activity of horseradish peroxidase by nitrogenous compounds.

1988 • 19 citations

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Hydroxylation of Phenol to Hydroquinone Catalyzed by A Human Myeloperoxidase-Superoxide… (1991) – Free Radical Research Communications | Metascience Observatory Explorer