Characterization of an Enhancer Element in the Human Apolipoprotein C-III Gene That Regulates Human Apolipoprotein A-I Gene Expression in the Intestinal Epithelium

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1987 • 64,270 citations

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1987 • 45,673 citations

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1988 • 11,455 citations

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1988 • 7,590 citations

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1974 • 1,697 citations

Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily.

1990 • 1,044 citations

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1983 • 992 citations

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1991 • 990 citations

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1974 • 618 citations

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1994 • 572 citations

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1974 • 565 citations

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1991 • 382 citations

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1985 • 361 citations

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1992 • 325 citations

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1974 • 310 citations

Antagonism between apolipoprotein AI regulatory protein 1, Ear3/COUP-TF, and hepatocyte nuclear factor 4 modulates apolipoprotein CIII gene expression in liver and intestinal cells.

1992 • 279 citations

Expression of human apolipoprotein A-I in transgenic mice results in reduced plasma levels of murine apolipoprotein A-I and the appearance of two new high density lipoprotein size subclasses.

1991 • 272 citations

Differentiation and self-renewal in the mouse gastrointestinal epithelium

1994 • 256 citations

The stem‐cell zone of the small intestinal epithelium. I. Evidence from paneth cells in the adult mouse

1981 • 253 citations

High Levels of Human Apolipoprotein A-I in Transgenic Mice Result in Increased Plasma Levels of Small High Density Lipoprotein (HDL) Particles Comparable to Human HDL3

1989 • 238 citations

Plasma apolipoprotein A-1 absence associated with a marked reduction of high density lipoproteins and premature coronary artery disease.

1982 • 235 citations

Distribution of apolipoprotein A-I, C-II, C-III, and E mRNA in fetal human tissues. Time-dependent induction of apolipoprotein E mRNA by cultures of human monocyte-macrophages

1985 • 200 citations

The stem‐cell zone of the small intestinal epithelium. III. Evidence from columnar, enteroendocrine, and mucous cells in the adult mouse

1981 • 193 citations

Cell migration pathway in the intestinal epithelium: An in situ marker system using mouse aggregation chimeras

1985 • 187 citations

Use of transgenic mice to map cis-acting elements in the intestinal fatty acid binding protein gene (Fabpi) that control its cell lineage-specific and regional patterns of expression along the duodenal-colonic and crypt-villus axes of the gut epithelium.

1992 • 179 citations

Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine IV. Paneth cells

1974 • 169 citations

The nucleotide and derived amino acid sequence of human apolipoprotein A-IV mRNA and the close linkage of its gene to the genes of apolipoproteins A-I and C-III.

1986 • 156 citations

Somatic Mutation, Monoclonality and Stochastic Models of Stem Cell Organization in the Intestinal Crypt

1993 • 154 citations

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1992 • 153 citations

Repression by ARP-1 sensitizes apolipoprotein AI gene responsiveness to RXR alpha and retinoic acid.

1992 • 135 citations

Synergistic interactions between transcription factors control expression of the apolipoprotein AI gene in liver cells.

1991 • 128 citations

Use of transgenic mice to map cis-acting elements in the liver fatty acid-binding protein gene (Fabpl) that regulate its cell lineage-specific, differentiation-dependent, and spatial patterns of expression in the gut epithelium and in the liver acinus.

1993 • 124 citations

Spatial differentiation of the intestinal epithelium: analysis of enteroendocrine cells containing immunoreactive serotonin, secretin, and substance P in normal and transgenic mice.

1990 • 123 citations

Expression of the human apolipoprotein E gene is regulated by multiple positive and negative elements.

1988 • 120 citations

Mapping enteroendocrine cell populations in transgenic mice reveals an unexpected degree of complexity in cellular differentiation within the gastrointestinal tract.

1990 • 115 citations

Different cis-acting DNA elements control expression of the human apolipoprotein AI gene in different cell types.

1988 • 113 citations

Promoter elements and factors involved in hepatic transcription of the human ApoA-I gene positive and negative regulators bind to overlapping sites.

1991 • 112 citations

Intestinal expression of the human apoA-I gene in transgenic mice is controlled by a DNA region 3' to the gene in the promoter of the adjacent convergently transcribed apoC-III gene.

1993 • 100 citations

The mouse ileal lipid-binding protein gene: a model for studying axial patterning during gut morphogenesis.

1994 • 90 citations

The use of antibodies to 5-bromo-2'-deoxyuridine for the isolation of DNA sequences containing excision-repair sites.

1984 • 85 citations

Comparison of the patterns of expression of rat intestinal fatty acid binding protein/human growth hormone fusion genes in cultured intestinal epithelial cell lines and in the gut epithelium of transgenic mice

1993 • 80 citations

Apolipoprotein Localization and Quantitation in the Human Intestine

1982 • 78 citations

A polymorphism (G–>A transition) in the -78 position of the apolipoprotein A-I promoter increases transcription efficiency

1994 • 76 citations

Transcriptional repression of apolipoprotein AI gene expression by orphan receptor ARP-1.

1994 • 65 citations

A solution hybridization/RNase protection assay with riboprobes to determine absolute levels of apoB, A-I, and E mRNA in human hepatoma cell lines.

1990 • 51 citations

Use of transgenic mice to study the routing of secretory proteins in intestinal epithelial cells: analysis of human growth hormone compartmentalization as a function of cell type and differentiation.

1989 • 51 citations

Cryosubstitution dehydration of aldehyde-fixed tissue: a favorable approach to quantitative immunocytochemistry.

1994 • 33 citations