Analysis of large deletions in theHPRT gene of primary human fibroblasts using the polymerase chain reaction

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Deletion screening of the Duchenne muscular dystrophy locus via multiplex DNA amplification

1988 • 1,260 citations

Mutator phenotype of Werner syndrome is characterized by extensive deletions.

1989 • 417 citations

Radiation-Induced Chromosome Damage in Man

1984 • 387 citations

Automated DNA sequencing of the human HPRT locus

1990 • 357 citations

Multiplex DNA deletion detection and exon sequencing of the hypoxanthine phosphoribosyltransferase gene in Lesch-Nyhan families

1990 • 328 citations

Effect of gamma rays at the dihydrofolate reductase locus: Deletions and inversions

1986 • 233 citations

The nature of mutants induced by ionising radiation in cultured hamster cells III. Molecular characterization of HPRT-deficient mutants induced by γ-rays or α-particles showing that the majority have deletions of all or part of the hprt gene

1986 • 207 citations

Radiation-induced chromosome damage in man

1983 • 188 citations

Somatic cell mutation detection and quantification of X-ray-induced mutation in cultured, diploid human fibroblasts

1973 • 169 citations

A further assessment of factors influencing measurements of thioguanine-resistant mutant frequency in circulating T-lymphocytes

1988 • 142 citations

Specific-locus mutations induced in eukaryotes (especially mammalian cells) by radiation and chemicals: a perspective

1989 • 138 citations

Hypomutability in Fanconi anemia cells is associated with increased deletion frequency at the HPRT locus.

1990 • 120 citations

Gene expression from transcriptionally disabled retroviral vectors.

1987 • 120 citations

Genetics of an X-Linked Disorder of Uric Acid Metabolism and Cerebral Function

1967 • 114 citations

Changes in Radiosensitivity during thein VitroGrowth of Diploid Human Fibroblasts

1974 • 99 citations

Mapping the Lowe oculocerebrorenal syndrome to Xq24-q26 by use of restriction fragment length polymorphisms.

1987 • 95 citations

The induction of thioguanine-resistant mutants of Chinese hamster cells by γ-rays

1977 • 88 citations

Quantitative and Molecular Analyses of Radiation-Induced Mutation in AS52 Cells

1986 • 82 citations

Report of the committee on the genetic constitution of the X chromosome (Part 1 of 7)

1991 • 79 citations

SOUTHERN ANALYSIS OF GENOMIC ALTERATIONS IN GAMMA-RAY-INDUCED APRT- HAMSTER CELL MUTANTS

1986 • 77 citations

Molecular analyses of in vivo hprt mutations in human T-lymphocytes III. Longitudinal study of hprt gene structural alterations and T-cell clonal origins

1989 • 76 citations

X-ray-induced mutation to 6-thioguanine resistance in cultured human diploid fibroblasts

1976 • 76 citations

Evidence for linear response for the induction of mutations in human cells by x-ray exposures below 10 rads.

1985 • 74 citations

Molecular analyses of in vivo hprt mutations in human T-lymphocytes I. Studies of low frequency ‘spontaneous’ mutants by Southern blots

1987 • 71 citations

Structure and sequence of mutations induced by ionizing radiation at selectable loci in Chinese hamster ovary cells

1986 • 70 citations

Molecular characterization of X-ray-induced mutations at the HPRT locus in plateau-phase Chinese hamster ovary cells

1990 • 66 citations

Multipoint genetic mapping of the Xq26-q28 region in families with fragile X mental retardation and in normal families reveals tight linkage of markers in q26?q27

1987 • 63 citations

Molecular and biochemical analyses of spontaneous and X-ray induced mutants in human lymphoblastoid cells

1987 • 63 citations

Factors affecting the efficiency of purine analogues as selective agents for mutants of mammalian cells induced by ionising radiation

1976 • 57 citations

Mutations in human lymphocytes: Effect of X- and UV-irradiation

1984 • 56 citations

Yeast artificial chromosomes spanning 8 megabases and 10-15 centimorgans of human cytogenetic band Xq26.

1992 • 53 citations

Localization of deletion breakpoints in radiation-induced mutants of the hprt gene in hamster cells

1990 • 52 citations

Mutations to azaguanine resistance induced in cultured diploid human fibroblasts by the carcinogen, N-acetoxy-2-Acetylaminofluorene

1975 • 52 citations

Southern-blot analyses of human T-lymphocyte mutants induced in vitro by γ-irradiation

1990 • 52 citations

Mapping large spontaneous deletion endpoints in the human HPRT gene

1988 • 52 citations

Screening for steroid sulfatase (STS) gene deletions by multiplex DNA amplification

1990 • 50 citations

A simple, efficient method for the separate isolation of RNA and DNA from the same cells.

1990 • 49 citations

Molecular characterization of hprt mutants induced by low- and hgh-LET radiations in human cells

1990 • 48 citations

Molecular basis of X-ray-induced mutation at the HPRT locus in human lumphocytes

1986 • 47 citations

Mutations in human lymphocytes effect of x irradiation and uv irradiation

1984 • 47 citations

Molecular analyses of in vivo hprt mutations in human t‐lymphocytes: IV. Studies in Newborns

1989 • 47 citations

Molecular analysis of spontaneous hypoxanthine phosphoribosyltransferase mutations in thioguanine-resistant HL-60 human leukemia cells.

1989 • 41 citations

Rapid screening for deletion mutations in the hprt gene using the polymerase chain reaction: X-ray and α-particle mutant spectra

1992 • 39 citations

Fine structure mapping of the hypoxanthine-guanine phosphoribosyltransferase (HPRT) gene region of the human X chromosome (Xq26).

1991 • 37 citations

The nature of mutants by ionising radiation in cultured hamster cells

1984 • 31 citations

Molecular analysis of spontaneous and ethyl methanesulphonate-induced mutations of the hprt gene in hamster cells

1989 • 29 citations

The isolation and preliminary characterisation of 6-thioguanine-resistant mutants of human diploid fibroblasts

1976 • 29 citations

Molecular changes in UV-induced and γ-ray-induced mutations in human lymphoblastoid cells

1990 • 16 citations

Radiation-induced Specific Locus Mutations in Human Mammary Epithelial Cells

1985 • 8 citations

X-Ray-Induced Mutations in Cultured Human Thyroid Cells

1989 • 7 citations

An anonymous single copy X-chromosome clone, DXS79, from Xq26-Xq28, identifies a moderately frequent RFLP [HGM8 provisional no. DXS79]

1985 • 5 citations

Radiation-induced Specific Locus Mutations in Human Mammary Epithelial Cells

1985 • 3 citations