The human tumor cloning assay in cancer research and therapy: A review with clinical correlations

Primary Bioassay of Human Tumor Stem Cells

1977 • 1,625 citations

Quantitation of Differential Sensitivity of Human-Tumor Stem Cells to Anticancer Drugs

1978 • 982 citations

Cellular tumorigenicity in nude mice: Correlation with cell growth in semi-solid medium

1974 • 814 citations

Primary Bioassay of Human Myeloma Stem Cells

1977 • 478 citations

Association between human tumor colony-forming assay results and response of an individual patient's tumor to chemotherapy

1981 • 378 citations

A Critical Appraisal of the Human Tumor Stem-Cell Assay

1983 • 365 citations

Prospective clinical trial of a human tumor cloning system.

1983 • 340 citations

Direct cloning of human ovarian carcinoma cells in agar.

1978 • 305 citations

An in vitro colony assay for human tumours grown in immune-suppressed mice and treated in vivo with cytotoxic agents

1978 • 296 citations

Cloning of Human Tumor Stem Cells

1981 • 269 citations

Prognostic correlations and response to treatment in advanced metastatic malignant melanoma.

1974 • 218 citations

Application of a human tumor colony-forming assay to new drug screening.

1985 • 217 citations

Separation of blast cell and T-lymphocyte progenitors in the blood of patients with acute myeloblastic leukemia

1979 • 216 citations

A Stem Cell Model of Human Tumor Growth: Implications for Tumor Cell Clonogenic Assays<xref ref-type="fn" rid="FN2">2</xref>

1983 • 190 citations

A comparison of cell replacement in bone marrow, testis and three regions of surface epithelium

1979 • 180 citations

Growth of human tumour cell colonies from biopsies using two soft-agar techniques

1978 • 172 citations

IN-VITRO CLONOGENIC ASSAY FOR PREDICTING RESPONSE OF OVARIAN CANCER TO CHEMOTHERAPY

1980 • 165 citations

Chemosensitivity testing of human neoplasms using the soft agar colony assay

1984 • 144 citations

Preparation of permanent slides of intact soft-agar colony cultures of hematopoietic and tumor stem cells.

1979 • 136 citations

Perspectives on clonogenic tumor cells, stem cells, and oncogenes.

1984 • 133 citations

Chemosensitivity testing of human solid tumors. A review of 1582 assays with 258 clinical correlations

1984 • 131 citations

Effects of cloned human leukocyte interferons in the human tumor stem cell assay.

1983 • 127 citations

Rapid assay for evaluating the chemosensitivity of human tumors in soft agar culture.

1982 • 124 citations

Demonstration of the stem cell nature of clonogenic tumor cells from lung cancer patients.

1982 • 112 citations

Development of an agar-methyl cellulose clonogenic assay for cells in transitional cell carcinoma of the human bladder.

1979 • 105 citations

Karyotypic analysis of human ovarian carcinoma cells cloned in short term agar culture

1981 • 104 citations

The contribution of blast cell properties to outcome variation in acute myeloblastic leukemia (AML)

1982 • 102 citations

Direct cloning of human neuroblastoma cells in soft agar culture.

1980 • 97 citations

A Stem Cell Model of Human Tumor Growth: Implications for Tumor Cell Clonogenic Assays

1983 • 95 citations

Tabular summary of pharmacokinetic parameters relevant to in vitro drug assay.

1980 • 87 citations

Human myeloma in vitro colony growth: interrelationships between drug sensitivity, cell kinetics, and patient survival duration

1983 • 79 citations

Prediction of chemotherapy response in human leukemia using an in vitro chemotherapy sensitivity test on the leukemic colony-forming cells

1980 • 78 citations

Effect of host-cell interactions on clonogenic carcinoma cells in human malignant effusions

1980 • 76 citations

Human tumor cloning: Feasibility and clinical correlations

1981 • 74 citations

Evaluation of new-anthracycline analogs with the human tumor stem cell assay

1981 • 69 citations

Clinical Correlations of Drug Sensitivity in the Human Tumor Stem Cell Assay

1980 • 66 citations

Experimental studies of the biology of human small cell lung cancer.

1983 • 66 citations

Measurement of self-renewal in culture of clonogenic cells from human ovarian carcinoma

1981 • 65 citations

Effects on in vitro tumor growth of macrophages isolated from human ascitic ovarian tumors

1979 • 64 citations

Clinical correlations of in vitro drug sensitivity.

1980 • 62 citations

Growth of cell colonies in soft agar from biopsies of different human solid tumors.

1980 • 62 citations

Effect of Epidermal Growth Factor on Proliferation of Human Tumor Cells in Soft Agar<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1981 • 61 citations

Quantitation of the number of cells within tumor colonies in semisolid medium and their growth as oblate spheroids.

1984 • 60 citations

In vitro stem cell assay in head and neck squamous carcinoma

1980 • 60 citations

In vitro evaluation of anticancer drugs with the human tumor stem cell assay.

1981 • 60 citations

Limitations of the clonal agar assay for the assessment of primary human ovarian tumour biopsies

1982 • 60 citations

Cytotoxicity of Adriamycin and Daunorubicin for Normal and Leukemia Progenitor Cells of Man<xref ref-type="fn" rid="fn2">2</xref>

1979 • 59 citations

Colonial Growth in Agar ofcells Derived from Neoplastic and Non-Neoplastic Tissues of Children

1968 • 59 citations

Clinical relevance of predictive tests for cancer chemotherapy

1982 • 58 citations

PHA-induced colony formation in acute non-lymphocytic and chronic myeloid leukemia

1980 • 57 citations

Quantitative association between the in vitro human tumor stem cell assay and clinical response to cancer chemotherapy

1981 • 54 citations

Stability of solutions of antineoplastic agents during preparation and storage for in vitor assays

1985 • 53 citations

Method for measurement of self-renewal capacity of clonogenic cells from biopsies of metastatic human malignant melanoma.

1982 • 52 citations

Quantitation of drug sensitivity by human metastatic melanoma colony-forming units

1981 • 51 citations

Effect of epidermal growth factor on clonogenic growth of primary human tumor cells

1982 • 51 citations

Comparison of two soft-agar methods for assaying chemosensitivity of human tumours in vitro: Malignant melanomas

1981 • 51 citations

In Vitro Methods to Predict for Patient Response to Chemotherapy

1980 • 49 citations

Direct cloning of human breast cancer in soft agar culture

1982 • 49 citations

Clinical Correlations With Drug Sensitivities in the Clonogenic Assay

1982 • 48 citations

Clinical correlations of leukemic clonogenic cell chemosensitivity assessed by in vitro continuous exposure to drugs.

1983 • 48 citations

Evaluation of an automated image analysis system for counting human tumor colonies

1984 • 47 citations

The poor cloning ability in agar of human tumour cells from biopsies of primary tumours

1980 • 46 citations

In vitro drug assay: pharmacologic considerations.

1980 • 43 citations

Colony growth and chemosensitivity in vitro of human melanoma biopsies. relationship to clinical parameters

1982 • 41 citations

Improved growth of in vitro colonies in human acute leukemia with the feeding culture method.

1977 • 37 citations

Human melanoma colony formation in soft agar.

1980 • 37 citations

Use of an image analysis system to count colonies in stem cell assays of human tumors.

1980 • 37 citations

Colonial growth in agar of cells derived from adenovirus-induced hamster tumors.

1967 • 36 citations

Tumor growth stimulation in vitro by interferons

1983 • 36 citations

Effect of oxygen concentration on the growth and drug sensitivity of human melanoma cells in soft-agar clonogenic assay.

1982 • 35 citations

Evaluation of anticancer drug schedule dependency using an in vitro human tumor clonogenic assay

1984 • 32 citations

Phase I clinical investigation of 9,10-anthracenedicarboxaldehyde bis[(4,5-dihydro-1H-imidazol-2-yl)hydrazone] dihydrochloride with correlative in vitro human tumor clonogenic assay.

1982 • 32 citations

Human tumour karyology: marked analytic improvement by short-term agar culture

1980 • 32 citations

In‐use evaluation of the omnicon automated tumor colony counter

1983 • 32 citations

Expression of silver-stained nucleolar organizing regions (Ag-NORs) in human cancer

1981 • 32 citations

Culture of Human Head and Neck Cancer Stem Cells Using Soft Agar

1980 • 31 citations

Factors that influence growth of head and neck squamous carcinoma in the soft agar cloning assay

1984 • 30 citations

Improved culture conditions for clonogenic growth of primary human breast tumours

1984 • 30 citations

Clinical application of the clonogenic assay.

1983 • 29 citations

Quantitative and statistical analysis of the association between in vitro and in vivo studies.

1980 • 27 citations

Modulation of human tumor colony growth in soft agar by serum

1983 • 26 citations

Activity of human leukocyte interferon in a human tumor cloning system

1982 • 26 citations

Cloning efficiency. A possible prognostic indicator in squamous cell carcinoma of the head and neck

1983 • 25 citations

Applications of the human tumor stem cell assay to new drug evaluation and screening.

1980 • 25 citations

Direct cloning of human parathyroid hyperplasia cells in soft-agar culture.

1980 • 25 citations

In vitro chemosensitivities of human tumor stem cells to the Phase II drug 4'-(9-acridinylamino)methanesulfon-m-anisidide and prospective in vivo correlations.

1982 • 25 citations

Properties of anticancer agents relevant to in vitro determinations of human tumor cell sensitivity

1983 • 24 citations

Kinetics of clonogenic melanoma cell proliferation and the limits on growth within a bilayer agar system

1984 • 22 citations

The human tumor colony-forming chemosensitivity assay: A biological and clinical review

1984 • 22 citations

Standard laboratory procedures for in vitro assay of human tumor stem cells.

1980 • 21 citations

The human tumor stem cell assay revisited

1985 • 21 citations

An enzymatic method for the disaggregation of human solid tumors for studies of clonogenicity and biochemical determinants of drug action.

1980 • 21 citations

Breast cancer as analyzed by the human tumor stem cell assay.

1983 • 21 citations

Improved survival for relapsing ovarian cancer (OVCA) patients using the human tumor stem cell assay (HTSCA) to select chemotherapy (CRx)

1981 • 19 citations

Development of a bioassay for human myeloma colony-forming cells.

1980 • 19 citations

Storage of chemotherapy drugs for use in the human tumor stem cell assay

1984 • 19 citations

Potential and problems with growth of breast cancer in a human tumor cloning system

1981 • 18 citations

Automated scanning of bone marrow cell colonies growing in agar-containing glass capillaries

1976 • 18 citations

Chemosensitivity of human neoplasms with in vitro clone formation

1981 • 18 citations

A comparison of human tumour-cell clonogenicity in methylcellulose and agar culture

1980 • 18 citations

Cultivation of human melanomas in soft agar. Factors influencing plating efficiency and chemosensitivity

1981 • 18 citations

Modulation of tumour colony growth by irradiated accessory cells

1983 • 16 citations

Cytogenetic analysis of human tumor cells cloned in agar.

1980 • 16 citations

Cytotoxic efficacy of reconstituted and stored antitumor agents.

1985 • 15 citations

Protocols of procedures and techniques in chromosome analysis of tumor stem cell cultures in soft agar.

1980 • 14 citations

Growth of rhabdomyosarcoma colonies from pleural fluid.

1975 • 14 citations

The true predictive value of the human tumor stem cell assay: does a workable assay select for treatment responders?

1984 • 13 citations

Further experience in testing the sensitivity of human ovarian carcinoma cells to interferon in an in vitro semisolid agar culture system: comparison of solid and ascitic forms of the tumor.

1980 • 13 citations

Development of a bioassay for ovarian carcinoma colony-forming cells.

1980 • 12 citations

Chemotherapy sensitivity assessment of leukemic colony-forming cells with in vitro simultaneous exposure to multiple drugs: clinical correlations in acute nonlymphocytic leukemia.

1982 • 12 citations

Growth inhibitors in plasma derived human serum

1982 • 12 citations

In vitro clonogenicity of primary human tumor cells: quantitation and relationship to tumor stem cells.

1980 • 12 citations

PHA-induced blast colonies and kinetic parameters in acute myeloid leukemia

1982 • 11 citations

Correlations between clonogenicity and prognostic factors in human breast cancer

1984 • 11 citations

Usefulness of abrin as a positive control for the human tumor clonogenic assay

1983 • 11 citations

Capillary Tube Scanning Applied to In Vitro Mouse Marrow Granulocyte Growth

1973 • 10 citations

In vitro sensitivity of myeloblast clonogenic cells to doxorubicin, aclacinomycin A, and 4'-O-tetrapyranyl-doxorubicin: correlations with clinical responses.

1984 • 10 citations

Human Tumor Cloning Assay in Advanced Head and Neck Cancer: Prospective Correlative Trial

1983 • 10 citations

Chalone Inhibition of Granulocyte Colony Growth In Agar: Kinetic Quantitation By Capillary Tube Scanning

1978 • 9 citations

Clonogenic in vitro growth and histologic grading of primary human breast tumors

1985 • 8 citations

Sensitivity of renal cell carcinoma to leukocyte interferon in the human tumor clonogenic assay and clinical correlations

1984 • 8 citations

<i>In vitro </i>Colony Growth of Granulocytes, Macrophages, T and B Lymphocytes in Agar Capillaries

1979 • 8 citations

Human tumor stem cell clonogenic assay sensitivity in malignant tumors and clinical correlation.

1982 • 7 citations

Cancer drug sensitivity test has problems

1982 • 7 citations

Antiproliferative Effect of Natural Beta Interferon on Fresh Tumor Cells Analyzed in a Clonogenic Assay

1984 • 7 citations

Prognostic evaluation of human tumor cell in vitro cloning assay.

1982 • 6 citations

Application of a microsomal drug activation system in a human tumor cloning assay

1983 • 5 citations

Phase II study of carminomycin in a human tumor cloning assay

1984 • 5 citations

Soft-agar cloning of cells from patients with lymphoma.

1980 • 5 citations

Cloning of human neuroblastoma cells in soft agar.

1980 • 4 citations

Effect of autologous serum and steroid hormone receptors on direct cloning of human breast cancer.

1984 • 3 citations

Human ovarian cancer colony formation: growth from malignant washings and pharmacologic applications.

1980 • 2 citations

Clonogenic tumour cells

1984 • 2 citations

Deleted Work

1955 • 0 citations