Signal sequence recognition and protein targeting

Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites

1997 • 5,415 citations

The GTPase superfamily: a conserved switch for diverse cell functions

1990 • 2,330 citations

Signal sequences

1985 • 2,179 citations

Signal Sequence Recognition and Protein Targeting to the Endoplasmic Reticulum Membrane

1994 • 821 citations

Signal sequences: more than just greasy peptides

1998 • 544 citations

Model for signal sequence recognition from amino-acid sequence of 54K subunit of signal recognition particle

1989 • 474 citations

BiP Maintains the Permeability Barrier of the ER Membrane by Sealing the Lumenal End of the Translocon Pore before and Early in Translocation

1998 • 427 citations

Alignment of Conduits for the Nascent Polypeptide Chain in the Ribosome-Sec61 Complex

1997 • 347 citations

Crystal structure of a bacterial signal peptidase in complex with a β-lactam inhibitor

1998 • 306 citations

The Escherichia coli SRP and SecB targeting pathways converge at the translocon

1998 • 292 citations

Crystal Structure of the Signal Sequence Binding Subunit of the Signal Recognition Particle

1998 • 283 citations

Early events in preprotein recognition in E. coli: interaction of SRP and trigger factor with nascent polypeptides.

1995 • 276 citations

Species‐specific variation in signal peptide design Implications for protein secretion in foreign hosts

1989 • 254 citations

Structure of the conserved GTPase domain of the signal recognition particle

1997 • 229 citations

Requirement of GTP Hydrolysis for Dissociation of the Signal Recognition Particle from Its Receptor

1991 • 222 citations

Crystal structure of the NG domain from the signal-recognition particle receptor FtsY

1997 • 210 citations

Co-translational protein targeting catalyzed by the Escherichia coli signal recognition particle and its receptor

1997 • 187 citations

Signal Sequences: The Same Yet Different

1996 • 108 citations

The Signal Recognition Particle Database (SRPDB)

1999 • 99 citations

Molecular evolution of SRP cycle components: functional implications

1994 • 86 citations

Functional changes in the structure of the SRP GTPase on binding GDP and Mg2+GDP.

1999 • 86 citations

The nascent polypeptide-associated complex modulates interactions between the signal recognition particle and the ribosome

1996 • 82 citations

The signal recognition particle receptor of Escherichia coli (FtsY) has a nucleotide exchange factor built into the GTPase domain

1997 • 80 citations

GTPase domain of the 54-kD subunit of the mammalian signal recognition particle is required for protein translocation but not for signal sequence binding.

1993 • 78 citations

Domain Interactions in E. coli SRP: Stabilization of M Domain by RNA Is Required for Effective Signal Sequence Modulation of NG Domain

1997 • 78 citations

A general mechanism for regulation of access to the translocon: Competition for a membrane attachment site on ribosomes

1998 • 72 citations

Interaction of Guanine Nucleotides with the Signal Recognition Particle from Escherichia coli

1998 • 56 citations

Structure of the phylogenetically most conserved domain of SRP RNA

1999 • 51 citations

Sorting of invertase signal peptide mutants in yeast dependent and independent on the signal‐recognition particle

1998 • 40 citations

Structure of the most conserved internal loop in SRP RNA.

1999 • 40 citations

Identification of a Region of Bacillus subtilis Ffh, a Homologue of Mammalian SRP54 Protein, That Is Essential for Binding to Small Cytoplasmic RNA

1996 • 35 citations

Another Factor Besides Hydrophobicity Can Affect Signal Peptide Interaction with Signal Recognition Particle

1998 • 31 citations

Binding of GTP and GDP induces a significant conformational change in the GTPase domain of Ffh, a bacterial homologue of the SRP 54 kDa subunit

1998 • 12 citations

Protein targeting: Getting into the groove

1998 • 12 citations