Increased local angiotensin II formation in aneurysmal aorta

Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques.

1994 • 2,497 citations

Transcriptional regulation of endothelial cell adhesion molecules: NF‐κB and cytokine‐inducible enhancers

1995 • 1,715 citations

Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E–deficient mice

2000 • 1,306 citations

Reactive oxygen species produced by macrophage-derived foam cells regulate the activity of vascular matrix metalloproteinases in vitro. Implications for atherosclerotic plaque stability.

1996 • 1,132 citations

Increased NADH-Oxidase–Mediated Superoxide Production in the Early Stages of Atherosclerosis

1999 • 689 citations

Expression of Angiotensin II and Interleukin 6 in Human Coronary Atherosclerotic Plaques

2000 • 649 citations

Angiotensin-Converting Enzyme Inhibition Prevents Arterial Nuclear Factor-κB Activation, Monocyte Chemoattractant Protein-1 Expression, and Macrophage Infiltration in a Rabbit Model of Early Accelerated Atherosclerosis

1997 • 502 citations

Prognosis of Abdominal Aortic Aneurysms

1989 • 486 citations

Angiotensin II Induces Monocyte Chemoattractant Protein-1 Gene Expression in Rat Vascular Smooth Muscle Cells

1998 • 388 citations

Association Between Myocardial Infarction and the Mast Cells in the Adventitia of the Infarct-Related Coronary Artery

1999 • 347 citations

Activation of human interstitial procollagenase through direct cleavage of the Leu83-Thr84 bond by mast cell chymase.

1994 • 320 citations

Contribution of Microglia/Macrophages to Expansion of Infarction and Response of Oligodendrocytes After Focal Cerebral Ischemia in Rats

2000 • 281 citations

Inhibition of Early Atherogenesis by Losartan in Monkeys With Diet-Induced Hypercholesterolemia

2000 • 274 citations

Angiotensin and cell growth

1991 • 266 citations

Angiotensin II Induces LOX-1, the Human Endothelial Receptor for Oxidized Low-Density Lipoprotein

1999 • 254 citations

Upregulation of renin-angiotensin system during differentiation of monocytes to macrophages

1999 • 222 citations

Mast cells of two types differing in neutral protease composition in the human aortic intima. Demonstration of tryptase- and tryptase/chymase-containing mast cells in normal intimas, fatty streaks, and the shoulder region of atheromas.

1994 • 171 citations

Suppression of experimental abdominal aortic aneurysms in the rat by treatment with angiotensin-converting enzyme inhibitors

2001 • 155 citations

Renin-angiotensin blockade lowers MCP-1 expression in diabetic rats

1999 • 154 citations

Expression and Localization of Matrix Metalloproteinase-12 in the Aorta of Cholesterol-Fed Rabbits

1998 • 153 citations

Angiotensin II stimulates macrophage-mediated oxidation of low density lipoproteins

1995 • 151 citations

Adventitial elastolysis is a primary event in aneurysm formation

1993 • 150 citations

Induction of the proto-oncogene c-jun by angiotensin II.

1990 • 143 citations

Basic science of abdominal aortic aneurysms: emerging therapeutic strategies for an unresolved clinical problem

1996 • 130 citations

Factors influencing enlargement rate of small abdominal aortic aneurysms

1987 • 122 citations

Adventitial Mast Cells Connect With Sensory Nerve Fibers in Atherosclerotic Coronary Arteries

2000 • 119 citations

Angiotensin II Increases Macrophage-mediated Modification of Low Density Lipoprotein via a Lipoxygenase-dependent Pathway

1997 • 117 citations

Influence of hypertension on aortic atherosclerosis in the Watanabe rabbit.

1989 • 116 citations

Monocyte chemoattractant protein-1 and macrophage infiltration in hypertensive kidney injury

2000 • 113 citations

Chymase-Dependent Angiotensin II Formation in Human Vascular Tissue

1999 • 107 citations

Enhanced expression of angiotensin-converting enzyme is associated with progression of coronary atherosclerosis in humans

1997 • 106 citations

Growth rate of abdominal aortic aneurysms as measured by computed tomography

1985 • 98 citations

Characterization of chymase from human vascular tissues

1997 • 96 citations

Angiotensin, LDL peroxidation and atherosclerosis

1998 • 92 citations

Mast Cell Tissue Inhibitor of Metalloproteinase-1 Is Cleaved and Inactivated Extracellularly by α-Chymase

2001 • 90 citations

Anti‐atherosclerotic effects of an angiotensin converting enzyme inhibitor and an angiotensin II antagonist in Cynomolgus monkeys fed a high‐cholesterol diet

1999 • 86 citations

Pathogenesis of abdominal aortic aneurysm: an update and look toward the future

1997 • 80 citations

Mast cell mediators with emphasis on intestinal mast cells.

1984 • 71 citations

Upregulation of Angiotensin-Converting Enzyme During the Healing Process After Injury at the Site of Percutaneous Transluminal Coronary Angioplasty in Humans

1997 • 70 citations

Mast cells are critical for the production of leukotrienes responsible for neutrophil recruitment in immune complex-induced peritonitis in mice.

1991 • 65 citations

Inhibition of chymase reduces vascular proliferation in dog grafted veins

2000 • 57 citations

ANGIOTENSIN‐CONVERTING ENZYME INHIBITORS AND ATHEROSCLEROSIS: RELEVANCE OF ANIMAL MODELS TO HUMAN DISEASE

1996 • 41 citations

Mast cell infiltration: a possible mechanism for vein graft vasospasm.

1988 • 38 citations

Angiotensin II receptor antagonist, L-158,809, prevents intimal hyperplasia in dog grafted veins

2000 • 27 citations

EFFECT OF PERINDOPRIL ON THE DEVELOPMENT OF ATHEROSCLEROSIS IN THE CHOLESTEROL‐FED RABBIT

1992 • 21 citations

Angiotensin II Type 1 Receptor Antagonist, TCV-116, Prevents Neointima Formation in Injured Arteries in the Dog

1999 • 15 citations

Antiatherosclerotic Effect of Alacepril, an Angiotensin-Converting Enzyme Inhibitor, in Monkeys Fed a High-Cholesterol Diet.

1999 • 14 citations