The healing wound: A case for extracellular matrix

Nitric oxide as a secretory product of mammalian cells

1992 • 4,437 citations

Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts

1993 • 2,169 citations

Pathological hypertrophy and cardiac interstitium. Fibrosis and renin-angiotensin-aldosterone system.

1991 • 2,017 citations

How does the extracellular matrix direct gene expression?

1982 • 1,475 citations

Molecular characterization of angiotensin II--induced hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts. Critical role of the AT1 receptor subtype.

1993 • 1,420 citations

Alpha-smooth muscle actin is transiently expressed by myofibroblasts during experimental wound healing.

1990 • 1,176 citations

Differentiation repertoire of fibroblastic cells: expression of cytoskeletal proteins as marker of phenotypic modulations.

1990 • 838 citations

GRANULATION TISSUE AS A CONTRACTILE ORGAN

1972 • 802 citations

Collagen Metabolism in Cultured Adult Rat Cardiac Fibroblasts: Response to Angiotensin II and Aldosterone

1994 • 679 citations

Structural basis of end-stage failure in ischemic cardiomyopathy in humans.

1994 • 583 citations

The pericyte—A review

1986 • 563 citations

Collagen remodeling of the pressure-overloaded, hypertrophied nonhuman primate myocardium.

1988 • 557 citations

Myocardial fibrosis: functional significance and regulatory factors

1993 • 484 citations

Regulation of collagen degradation in the rat myocardium after infarction

1995 • 469 citations

Tissue-specific activation of cardiac angiotensin converting enzyme in experimental heart failure.

1991 • 466 citations

Angiotensin-converting enzyme: new concepts concerning its biological role

1989 • 400 citations

The alpha-smooth muscle actin-positive cells in healing human myocardial scars.

1994 • 380 citations

Identification of functional angiotensin II receptors on rat cardiac fibroblasts.

1993 • 361 citations

Growth factors in wound healing

1994 • 326 citations

Role of fibroblast subpopulations in periodontal physiology and pathology

1991 • 323 citations

In vivo co-distribution of fibronectin and actin fibers in granulation tissue: immunofluorescence and electron microscope studies of the fibronexus at the myofibroblast surface.

1984 • 261 citations

Endothelin: Potential Role in Hypertension and Vascular Hypertrophy

1995 • 240 citations

Structural remodeling in hypertensive heart disease and the role of hormones.

1994 • 237 citations

Transforming Growth Factor Beta-1 in Acute Myocardial Infarction in Rats

1988 • 232 citations

Hormonal and cardiac effects of converting enzyme inhibition in rat myocardial infarction.

1988 • 226 citations

Interstitial cells of the heart valves possess characteristics similar to smooth muscle cells.

1986 • 209 citations

Localization of angiotensin converting enzyme in rat heart.

1991 • 205 citations

Cardiac angiotensin converting enzyme and myocardial fibrosis in the rat

1994 • 199 citations

Intracardiac detection of angiotensinogen and renin: a localized renin-angiotensin system in neonatal rat heart

1992 • 197 citations

Selective Activation of Cardiac Angiotensinogen Gene Expression in Post-infarction Ventricular Remodeling in the Rat

1993 • 194 citations

Distribution and functional significance of cardiac angiotensin converting enzyme in hypertrophied rat hearts.

1993 • 191 citations

Healing after myocardial infarction in the dog: Changes in infarct hydroxyproline and topography

1986 • 185 citations

Increased angiotensin-I converting enzyme gene expression in the failing human heart. Quantification by competitive RNA polymerase chain reaction.

1994 • 184 citations

Angiotensin II Receptor Blockade After Myocardial Infarction in Rats

1992 • 178 citations

Collagen phenotypes during development and regression of myocardial hypertrophy in spontaneously hypertensive rats.

1990 • 174 citations

Role of collagen in acute myocardial infarct expansion.

1991 • 173 citations

Detection of angiotensin I and II in cultured rat cardiac myocytes and fibroblasts

1992 • 172 citations

Hormone interactions in the isolated rabbit heart. Synthesis and coronary vasomotor effects of prostaglandins, angiotensin, and bradykinin.

1975 • 160 citations

Cellular Distribution of Angiotensin-Converting Enzyme After Myocardial Infarction

1995 • 157 citations

DNA synthesis in the non-infarcted cardiac interstitium after left coronary artery ligation in the rat: Effects of captopril

1991 • 156 citations

Contribution of Cardiac Renin-Angiotensin System to Ventricular Remodelling in Myocardial-Infarcted Rats

1993 • 153 citations

Immunofluorescent localization of angiotensin converting enzyme in epithelioid and giant cells of sarcoidosis granulomas.

1979 • 152 citations

Feedback regulation of angiotensin converting enzyme activity and mRNA levels by angiotensin II.

1993 • 152 citations

Interstitial Collagen is Increased in the Non-infarcted Human Myocardium After Myocardial Infarction

1993 • 148 citations

Cellular Localization of Angiotensinogen Gene Expression in Brown Adipose Tissue and Mesentery: Quantification of Messenger Ribonucleic Acid Abundance Using Hybridization in Situ*

1987 • 147 citations

Enhanced deposition of predominantly type I collagen in myocardial disease

1990 • 141 citations

Angiotensin converting enzyme inhibition prevents the increase in aortic collagen in rats.

1994 • 140 citations

Angiotensin II receptor binding following myocardial infarction in the rat

1994 • 136 citations

Localization of angiotensinogen messenger RNA in rat aorta.

1988 • 136 citations

The story of the myofibroblasts

1979 • 133 citations

Effects of endogenously produced leukotrienes, thromboxane, and prostaglandins on coronary vascular resistance in rabbit myocardial infarction.

1985 • 125 citations

Angiotensin-converting enzyme and myocardial fibrosis in the rat receiving angiotensin II or aldosterone.

1993 • 120 citations

Biosynthesis of prostacyclin (PGI2) and 12L-hydroxy-5,8,10,14-eicosatetraenoic acid (HETE) by pericardium, pleura, peritoneum and aorta of the rabbit

1979 • 108 citations

The granulocyte-angiotensin system. Angiotensin I-converting activity of cathepsin G.

1982 • 107 citations

Fibroblast prostaglandin E2 synthesis. Persistence of an abnormal phenotype after short-term exposure to mononuclear cell products.

1983 • 106 citations

Regional differences in LV collagen accumulation and mature cross-linking after myocardial infarction in rats

1994 • 105 citations

Effect of Growth Factors on Collagen Metabolism in Cultured Human Heart Fibroblasts

1991 • 103 citations

Bradykinin stimulates phospholipid methylation, calcium influx, prostaglandin formation, and cAMP accumulation in human fibroblasts.

1983 • 85 citations

Contractile cells in rat myocardial scar tissue.

1991 • 84 citations

Angiotensin II and aldosterone receptor binding in rat heart and kidney: response to chronic angiotensin II or aldosterone administration.

1993 • 80 citations

Connective tissue: a metabolic Entity?

1995 • 78 citations

Immunohistochemical study of angiotensin-converting enzyme in human tissues using monoclonal antibodies

1987 • 73 citations

Angiotensin converting enzyme and kininase-II-like activities in cultured valvular interstitial cells of the rat heart

1995 • 73 citations

Fibrosis-induced reduction of endomyocardium in the rat after isoproterenol treatment.

1989 • 72 citations

Enalapril suppresses normal accumulation of elastin and collagen in cardiovascular tissues of growing rats

1992 • 70 citations

Effect of Enalapril on Ventricular Remodeling and Function During Healing After Anterior Myocardial Infarction in the Dog

1995 • 57 citations

Angiotensin-converting enzyme, bradykinin, and angiotensin II receptor binding in rat skin, tendon, and heart valves: an in vitro, quantitative autoradiographic study.

1994 • 55 citations

Inhibition of angiotensin-converting enzyme and attenuation of myocardial fibrosis by lisinopril in rats receiving angiotensin II.

1995 • 53 citations

Wound healing in cardiovascular disease

1995 • 51 citations

Effect of endothelin-1 on croton oil-induced granulation tissue in the rat. A pharmacologic and immunohistochemical study.

1992 • 51 citations

In vitro autoradiographic localization of binding to angiotensin receptors in the rat heart

1990 • 51 citations

Culture of mesothelial cells from bovine pericardium and characterization of their arachidonate metabolism

1987 • 44 citations

Autoradiographic Localization and Quantification of Rat Heart Angiotensin Converting Enzyme

1991 • 41 citations

The arachidonic acid metabolic capacity of canine myocardium is increased during healing of acute myocardial infarction.

1982 • 40 citations

Studies on collagen in the experimental myocardial infarction.

1985 • 23 citations

Arachidonate metabolism in cultured fibroblasts derived from normal and infarcted canine heart.

1989 • 23 citations

Hormones and Fibrosis: A Case for Lost Reciprocal Regulation

1994 • 22 citations

Effect of left ventricular unloading with captopril on remodelling and function during healing of anterior transmural myocardial infarction in the dog.

1992 • 21 citations

Bradykinin receptor and tissue ACE binding in myocardial fibrosis: Response to chronic angiotensin II or aldosterone administration in rats

1995 • 21 citations

Snakes and seaweed: a case of the swollen organ

1995 • 5 citations