Mutants of CHO cells resistant to the protein synthesis inhibitors, cryptopleurine and tylocrebrine: genetic and biochemical evidence for common site of action of emetine, cryptopleurine, tylocrebrine, and tubulosine

Inhibitors of Ribosome Functions

1971 • 672 citations

The Mechanism by which Cycloheximide and Related Glutarimide Antibiotics Inhibit Peptide Synthesis on Reticulocyte Ribosomes

1971 • 507 citations

Pleiotropic phenotype of colchicine‐resistant CHO cells: Cross‐resistance and collateral sensitivity

1976 • 314 citations

Chapter 7: Isolation of Mutants of Cultured Mammalian Cells

1973 • 232 citations

Inhibitors of Protein Biosynthesis

1968 • 230 citations

STRUCTURAL BASIS FOR INHIBITION OF PROTEIN SYNTHESIS BY EMETINE AND CYCLOHEXIMIDE BASED ON AN ANALOGY BETWEEN IPECAC ALKALOIDS AND GLUTARIMIDE ANTIBIOTICS

1966 • 223 citations

Mechanism of Cycloheximide Inhibition of Protein Synthesis in a Cell-free System Prepared from Rat Liver

1969 • 201 citations

The molecular basis of emetine resistance in chinese hamster ovary cells: Alteration in the 40S ribosomal subunit

1977 • 105 citations

The isolation and preliminary characterization of somatic cell mutants resistant to the protein synthesis inhibitor—Emetine

1976 • 104 citations

Inhibitors of protein synthesis by ribosomes of the 80-S type

1971 • 99 citations

Inhibition of protein synthesis in ehrlich ascites-tumour cells by the phenanthrene alkaloids tylophorine, tylocrebrine and cryptopleurine

1968 • 96 citations

Cycloheximide resistance in yeast: A property of the 60s ribosomal subunit

1967 • 94 citations

Cryptopleurine Resistance: Genetic Locus for a 40 S Ribosomal Component in Saccharomyces cerevisiae

1974 • 89 citations

Simultaneous ribosomal resistance to trichodermin and anisomycin in Saccharomyces cerevisiae mutants

1975 • 87 citations

EMETINE TOXICITY IN MAN: STUDIES ON THE NATURE OF EARLY TOXIC MANIFESTATIONS, THEIR RELATION TO THE DOSE LEVEL, AND THEIR SIGNIFICANCE IN DETERMINING SAFE DOSAGE

1948 • 82 citations

Modification of Ribosomes in Cryptopleurine-Resistant Mutants of Yeast

1973 • 78 citations

Trichodermin resistance—mutation affecting eukaryotic ribosomes

1974 • 71 citations

Phase I experience with emetine hydrochloride (NSC 33669) as an antitumor agent

1971 • 56 citations

Studies on Transfer Ribonucleic Acid-Ribosome Complexes

1972 • 54 citations

Mode of action of tylocrebrine: effects on protein and nucleic acid synthesis.

1972 • 52 citations

Structural Basis for the Inhibition of Protein Biosynthesis: Mode of Action of Tubulosine

1967 • 40 citations

Selected highlights in immunological research in the last decade

1974 • 39 citations

Chapter 2 Inhibitors of Macromolecular Synthesis in Yeast

1975 • 28 citations

Specific Inhibition of Translocation by Tubulosine in Eukaryotic Polysomes

1976 • 28 citations

Increased Lifespan of Leukemic Mice Treated with Drugs Related to (–)-Emetine

1971 • 25 citations

Peptidylpuromycin formation on mammalian polysomes. Transpeptidation and translocation

1973 • 23 citations

ACTION OF EMETIN ON MALIGNANT TUMORS

1918 • 13 citations